Engineered Nanomaterials for Infection Control and Healing Acute and Chronic Wounds

Abstract

Nanoengineered biomaterials have dramatically expanded the range of tools used for infection control and to accelerate wound healing. This review thoroughly describes the developments that are shaping this emerging field and evaluates the potential wound healing applications of recently developed engineered nanomaterials for both acute and chronic wounds. Specifically, we will assess the unique characteristics of engineered nanomaterials that render them applicable for wound healing and infection control. A range of engineered nanomaterials, including polymeric-, metallic- and ceramic-based nanomaterials, that could be used as therapeutic delivery agents to accelerate regeneration of damaged dermal and epidermal tissues are also detailed. Finally, we will detail the current state of engineered nanomaterials for wound regeneration and will identify promising new research directions in infection control.

Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels

“…The main goal is to obtain the optimal moist microenvironment for the wound [1]. A good moisture between the wound and the dressing is possible by an appropriate selection of materials [2], so it is very important to understand their behaviour in the swelling and release processes.…”

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

“…Wound healing follows a dynamic and orderly process, and according to the nature of wound healing, it can be classified into acute wound and chronic wound . Acute wounds, also known as normal wounds, are usually caused by mechanical, burn, or chemical injuries . The wounds can be completely healed with the smallest scar, and the healing time is usually 8–12 weeks …”

“…[20][21][22][23] Acute wounds, also known as normal wounds, are usually caused by mechanical, burn, or chemical injuries. [24][25][26] The wounds can be completely healed with the smallest scar, and the healing time is usually 8-12 weeks. [27,28] As we all know, healthy skin mainly includes epidermis, dermis, and subcutaneous.…”

Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications

“…84,85 NO plays an important role in inflammation, cellular proliferation, ECM matrix deposition, angiogenesis, and matrix remodeling. 23,86−88 Moreover, NO is an antibacterial agent effective against a broad range of bacteria, including biofilm forming microorganisms, through an oxidation process involving free radical superoxide (O 2 * – ) to form peroxynitrite (−OONO). Several studies investigated the controlled release of NO using nanoscale delivery systems.…”

“…33 As a result, nanoparticles have an ability to deliver a sustained and controlled release of therapeutics that results in an accelerated healing process. 23 …”