Engineered nanomaterials in terrestrial systems: Interactions with co-existing contaminants and trophic transfer

Zuverza‐Mena, Nubia; White, Jason C.

doi:10.1016/j.coesh.2018.08.003

Cited by 11 publications

(3 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Marked reduction in toxicity was observed in tri‐culture epithelial cell models following exposure to E171 TiO 2 transformed through their interaction with a standard food model. [ 129 ] ENM speciation change was also noted to affect ENM induced toxicity, demonstrated by a reduction in observed ecotoxicity caused by the transformation of Ag ENMs to Ag 2 S. [ 6b,130 ] Therefore, Ag ENMs transformation to Ag 2 S and AgCl species occurring due to their gastric dissolution and interaction with macromolecules along the GIT could reduce intestinal toxicity. Notably, transformation of E171 TiO 2 have been noted to increase the bioavailability and, hence, toxicity of the pesticide, boscalid, in a small intestine tri‐culture model.…”

Section: Enm Translocation Across Git and Toxicological Outcomes In Gmentioning

confidence: 99%

Transformation of Nanomaterials and Its Implications in Gut Nanotoxicology

Setyawati

Zhao

2020

Small

View full text Add to dashboard Cite

Ingestion of engineered nanomaterials (ENMs) is inevitable due to their widespread utilization in the agrifood industry. Safety evaluation has become pivotal to identify the consequences on human health of exposure to these ingested ENMs. Much of the current understanding of nanotoxicology in the gastrointestinal tract (GIT) is derived from studies utilizing pristine ENMs. In reality, agrifood ENMs interact with their microenvironment, and undergo multiple physicochemical transformations, such as aggregation/agglomeration, dissolution, speciation change, and surface characteristics alteration, across their life cycle from synthesis to consumption. This work sieves out the implications of ENM transformations on their behavior, stability, and reactivity in food and product matrices and through the GIT, in relation to measured toxicological profiles. In particular, a strong emphasis is given to understand the mechanisms through which these transformations can affect ENM induced gut nanotoxicity.

show abstract

Section: Enm Translocation Across Git and Toxicological Outcomes In Gmentioning

confidence: 99%

Transformation of Nanomaterials and Its Implications in Gut Nanotoxicology

Setyawati

Zhao

2020

Small

View full text Add to dashboard Cite

show abstract

“…Information about the trophic transfer of MNPs along terrestrial food chains is currently limited. The few published studies addressing the trophic transfer of MNPs along the terrestrial food chain have mainly focused on the influence of physicochemical properties of single MNPs, for instance, the size of MNPs. − In addition, other factors, including the coexistence of pollutants (such as MNPs, metals, and organic pollutants), can play a major role in affecting their fate in exposure media, bioavailability, and trophic transfer from producers to predators . Haghighat et al demonstrated that the co-exposure to AgNPs and TiO 2 NPs enhanced the bioaccumulation of Ag in the liver and intestine of common carp (Cyprinus carpio).…”

Section: Introductionmentioning

confidence: 99%

“…7−9 In addition, other factors, including the coexistence of pollutants (such as MNPs, metals, and organic pollutants), can play a major role in affecting their fate in exposure media, bioavailability, and trophic transfer from producers to predators. 10 Haghighat et al 11 demonstrated that the co-exposure to AgNPs and TiO 2 NPs enhanced the bioaccumulation of Ag in the liver and intestine of common carp (Cyprinus carpio). Tong et al 12,13 reported that TiO 2 NPs adsorbed dissolved the Zn released from ZnONPs and hence reduced the bacterial toxicity of ZnONPs.…”

Section: ■ Introductionmentioning

confidence: 99%

Toxicokinetics and Particle Number-Based Trophic Transfer of a Metallic Nanoparticle Mixture in a Terrestrial Food Chain

Sun

Bosker

et al. 2023

Environ. Sci. Technol.

View full text Add to dashboard Cite

Herein, we investigated to which extent metallic nanoparticles (MNPs) affect the trophic transfer of other coexisting MNPs from lettuce to terrestrial snails and the associated tissue-specific distribution using toxicokinetic (TK) modeling and single-particle inductively coupled plasma mass spectrometry. During a period of 22 days, snails were fed with lettuce leaves that were root exposed to AgNO 3 (0.05 mg/L), AgNPs (0.75 mg/L), TiO 2 NPs (200 mg/L), and a mixture of AgNPs and TiO 2 NPs (equivalent doses as for single NPs). The uptake rate constants (k u ) were 0.08 and 0.11 kg leaves/kg snail/d for Ag and 1.63 and 1.79 kg leaves/kg snail/d for Ti in snails fed with NPs single-and mixture-exposed lettuce, respectively. The elimination rate constants (k e ) of Ag in snails exposed to single AgNPs and mixed AgNPs were comparable to the corresponding k u , while the k e for Ti were lower than the corresponding k u . As a result, single TiO 2 NP treatments as well as exposure to mixtures containing TiO 2 NPs induced significant biomagnification from lettuce to snails with kinetic trophic transfer factors (TTF k ) of 7.99 and 6.46. The TTF k of Ag in the single AgNPs treatment (1.15 kg leaves/kg snail) was significantly greater than the TTF k in the mixture treatment (0.85 kg leaves/kg snail), while the fraction of Ag remaining in the body of snails after AgNPs exposure (36%) was lower than the Ag fraction remaining after mixture exposure (50%). These results indicated that the presence of TiO 2 NPs inhibited the trophic transfer of AgNPs from lettuce to snails but enhanced the retention of AgNPs in snails. Biomagnification of AgNPs from lettuce to snails was observed in an AgNPs single treatment using AgNPs number as the dose metric, which was reflected by the particle number-based TTFs of AgNPs in snails (1.67, i.e., higher than 1). The size distribution of AgNPs was shifted across the lettuce-snail food chain. By making use of particle-specific measurements and fitting TK processes, this research provides important implications for potential risks associated with the trophic transfer of MNP mixtures.

show abstract