Engineered Particle Surfaces

Davies, Reg; Schurr, George A.; Meenan, Paul; Nelson, Ralph D.; Bergna, Horacio E.; Brevett, Carol A.; Goldbaum, Richard H.

doi:10.1002/(sici)1521-4095(199810)10:15<1264::aid-adma1264>3.0.co;2-x

Cited by 154 publications

(36 citation statements)

References 5 publications

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“…[10] The term used to describe the synthesis of core±shell particles with defined morphologies and properties can be referred to as particle engineering. [2] This typically involves tailoring the surface properties of particles, often accomplished by coating or encapsulating them within a shell of a preferred material. Particle coating is carried out for a myriad of reasons.…”

Section: Introductionmentioning

confidence: 99%

“…[1±3] Although a variety of procedures have been employed for their manufacture, difficulties associated with their production have limited the application of the final colloidal materials. [2,14] Furthermore, despite the fact that the advantages of uniformly coated and stable colloidal particles have been recognized for years, [1±3,15] the controlled coating of colloids with organized layers has for many years remained a technical challenge. A major requirement pertaining to the procedures used to coat particles is that they do not cause aggregation, thus rendering the particles unusable for many purposes.…”

Section: Introductionmentioning

confidence: 99%

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Nanoengineering of Particle Surfaces

2001

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The creation of core–shell particles is attracting a great deal of interest because of the diverse applicability of these colloidal particles; e.g., as building blocks for photonic crystals, in multi‐enzyme biocatalysis, and in drug delivery. This review presents the state‐of‐the‐art in strategies for engineering particle surfaces, such as the layer‐by‐layer deposition process (see Figure), which allows fine control over shell thickness and composition.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanoengineering of Particle Surfaces

2001

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“…Many approaches have been done in the field of particle surface engineering (1), especially in the processing of lactose carrier surfaces for DPI. Controlled crystallization of lactose from different solvents was carried out to produce regular crystals with smooth surface (2,3).…”

Section: Introductionmentioning

confidence: 99%

Effective Modification of Particle Surface Properties Using Ultrasonic Water Mist

et al. 2009

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Abstract. The goal of the present study was to design a new technique to modify particle surface properties and, through that, to improve flowability of poorly flowing drug thiamine hydrochloride and pharmaceutical sugar lactose monohydrate of two different grades. The powdered particles were supplied by a vibratory feeder and exposed to an instantaneous effect of water mist generated from an ultrasound nebulizer. The processed and original powders were evaluated with respect to morphology (scanning electron microscopy, atomic force microscopy, and spatial filtering technique), flow, and solid state properties. It was found that rapid exposition of pharmaceutical materials by water mist resulted in the improvement of powder technical properties. The evident changes in flowability of coarser lactose were obviously due to smoothing of particle surface and decreasing in the level of fines with very slight increment in particle size. The changes in thiamine powder flow were mainly due to narrowing in particle size distribution where the tendency for better flow of finer lactose was related to surface and size modifications. The aqueous mist application did not cause any alteration of the crystal structures of the studied materials. The proposed water mist treatment technique appears to be a robust, rapid, and promising tool for the improvement of the technological properties of pharmaceutical powders.

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“…The synthesis of core±shell structures involves functionalization of the surface of particles, often accomplished by coating or encapsulating them with a different material with the desired surface properties. [1,2] The shell can be tuned, for example, to alter the charge and reactivity of the surface, thereby enhancing the stability and dispersability of the colloid. [3] At the same time, the coating can be used to tailor the magnetic, optical, or catalytic properties to obtain three-dimensional structures with a variety of enhanced functionalities.…”

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confidence: 99%

Water-Stable, Magnetic Silica-Cobalt/Cobalt Oxide-Silica Multishell Submicrometer Spheres

2005

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A method to produce monodisperse magnetic composite spheres with diameters from less than 100 nm to more than 1 μm in water solution is reported. The spheres consist of a dielectric silica core and a cobalt/cobalt oxide shell which can be protected from further oxidation with an outer shell of silica or, alternatively, they can be covered with the polymer polyvinylpyrrolidone as a stabilizer. The formation of a uniform magnetic shell proceeds with the adsorption of metallic cobalt seeds, produced by the reduction of cobalt chloride with sodium borohydride, on a self‐assembled layer of polyelectrolytes on the silica core. In the second step, an outer silica shell can be formed by the hydrolysis and condensation of (3‐aminopropyl)trimethoxysilane and tetraethoxysilane. The double‐shell composite spheres show excellent sphericity, monodispersity, and a magnetic hysteresis loop at room temperature.

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Engineered Particle Surfaces

Cited by 154 publications

References 5 publications

Nanoengineering of Particle Surfaces

Nanoengineering of Particle Surfaces

Effective Modification of Particle Surface Properties Using Ultrasonic Water Mist

Water-Stable, Magnetic Silica-Cobalt/Cobalt Oxide-Silica Multishell Submicrometer Spheres

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