Engineered superparamagnetic iron oxide nanoparticles (SPIONs) for dual-modality imaging of intracranial glioblastoma via EGFRvIII targeting

Liu, Xianping; Du, Chengjuan; Li, Haichun; Jiang, Ting; Luo, Zimiao; Pang, Zhiqing; Geng, Daoying; Zhang, Jun

doi:10.3762/bjnano.10.181

Cited by 16 publications

(10 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[71] Some studies designed dual-modality nanoprobes for both MRI and fluorescence imaging of cancer cells and tumors. In this regard, Liu et al [72] designed a brain-tumor-targeting nanoprobe using Cy7.5-labeled PEGylated SPION nanoparticles modified with an EGFRvIII-targeting peptide (PEPHC1 peptide; sequence: HFLIIGFMRRAACGA) for dual-modality imaging (MRI and fluorescence imaging) of glioblastoma. Both in vitro and in vivo MR and fluorescence imaging demonstrated that the synthesized nanoprobe effectively targeted glioblastoma tumors in a U87MG-EGFRvIII xenograft mouse model.…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

“…Both in vitro and in vivo MR and fluorescence imaging demonstrated that the synthesized nanoprobe effectively targeted glioblastoma tumors in a U87MG-EGFRvIII xenograft mouse model. [72] In another study, Ye et al [73] employed GE11-functionalized lanthanidedoped magnetic and fluorescent upconversion nanoparticles (UCNPs) for the detection of triple-negative breast cancer (TNBC) cells using dual MRI and fluorescence imaging. The NaGdF 4 :Yb 3 + , Er 3 + @NaGdF 4 nanoparticles were modified with polyacrylic acid (PAA), and then coupled with GE11 peptide using EDC and N-hydroxysuccinimide (NHS) for EGFR targeting.…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

See 1 more Smart Citation

Innovative Diagnostic Peptide‐Based Technologies for Cancer Diagnosis: Focus on EGFR‐Targeting Peptides

et al. 2022

View full text Add to dashboard Cite

Active targeting using biological ligands has emerged as a novel strategy for the targeted delivery of diagnostic agents to tumor cells. Conjugating functional targeting moieties with diagnostic probes can increase their accumulation in tumor cells and tissues, enhancing signal detection and, thus, the sensitivity of diagnosis. Due to their small size, ease of chemical synthesis and site‐specific modification, high tissue penetration, low immunogenicity, rapid blood clearance, low cost, and biosafety, peptides offer several advantages over antibodies and proteins in diagnostic applications. Epidermal growth factor receptor (EGFR) is one of the most promising cancer biomarkers for actively targeting diagnostic and therapeutic agents to tumor cells due to its active involvement and overexpression in various cancers. Several peptides for EGFR‐targeting have been identified in the last decades, which have been obtained by multiple means including derivation from natural proteins, phage display screening, positional scanning synthetic combinatorial library, and in silico screening. Many studies have used these peptides as a targeting moiety for diagnosing different cancers in vitro, in vivo, and in clinical trials. This review summarizes the progress of EGFR‐targeting peptide‐based assays in the molecular diagnosis of cancer.

show abstract

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Innovative Diagnostic Peptide‐Based Technologies for Cancer Diagnosis: Focus on EGFR‐Targeting Peptides

et al. 2022

View full text Add to dashboard Cite

show abstract

“…PEPHC1 peptide was attached to SPIONs to target EGFRvIII in GBM. Nanostructures were found to be biodegradable, non-toxic and tunable for tumor imaging [195]. The boundary between normal cells and glioma cells is very difficult to differentiate precisely.…”

Section: Multimodal Imaging With Nanomaterialsmentioning

confidence: 99%

Nanomaterials for Diagnosis and Treatment of Brain Cancer: Recent Updates

et al. 2020

View full text Add to dashboard Cite

Brain tumors, especially glioblastoma, remain the most aggressive form of all the cancers because of inefficient diagnosis and profiling. Nanostructures, such as metallic nanostructures, silica nano-vehicles, quantum dots, lipid nanoparticles (NPs) and polymeric NPs, with high specificity have made it possible to permeate the blood–brain barrier (BBB). NPs possess optical, magnetic and photodynamic properties that can be exploited by surface modification, bio composition, contrast agents’ encapsulation and coating by tumor-derived cells. Hence, nanotechnology has brought on a revolution in the field of diagnosis and imaging of brain tumors and cancers. Recently, nanomaterials with biomimetic functions have been introduced to efficiently cross the BBB to be engulfed by deep skin tumors and cancer malignancies for imaging. The review focuses on nanotechnology-based diagnostic and imaging approaches for exploration in brain tumors and cancers. Moreover, the review also summarizes a few strategies to image glioblastoma and cancers by multimodal functional nanocomposites for more precise and accurate clinical diagnosis. Their unique physicochemical attributes, including nanoscale sizes, larger surface area, explicit structural features and ability to encapsulate diverse molecules on their surface, render nanostructured materials as excellent nano-vehicles to cross the blood–brain barrier and convey drug molecules to their target region. This review sheds light on the current progress of various kinds of nanomaterials, such as liposomes, nano-micelles, dendrimers, carbon nanotubes, carbon dots and NPs (gold, silver and zinc oxide NPs), for efficient drug delivery in the treatment and diagnosis of brain cancer.

show abstract

“…In this study, first, U87 MG and two weeks later SPIONs were injected into mice. They found that brain tumour MR imaging signal was strong, and the fluorescence image of the major fluorescence intensity in the brains of the mice that received the substance showed higher than the control mice [ 84 ].…”

Section: Nanoparticles In Multi‐modal Imagingmentioning

confidence: 99%

Recent nanotheranostics applications for cancer therapy and diagnosis: A review

Aminolroayaei

Shahbazi‐Gahrouei

Shahbazi-Gahrouei

et al. 2021

IET Nanobiotechnology

View full text Add to dashboard Cite

Nanotheranostics has attracted much attention due to its widespread application in molecular imaging and cancer therapy. Molecular imaging using nanoparticles has attracted special attention in the diagnosis of cancer at early stages. With the progress made in nanotheranostics, studying drug release, accumulation in the target tissue, biodistribution, and treatment effectiveness are other important factors. However, according to the studies conducted in this regard, each nanoparticle has some advantages and limitations that should be examined and then used in clinical applications. The main goal of this review is to explore the recent advancements in nanotheranostics for cancer therapy and diagnosis. Then, it is attempted to present recent studies on nanotheranostics used as a contrast agent in various imaging modalities and a platform for cancer therapy.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

show abstract

Engineered superparamagnetic iron oxide nanoparticles (SPIONs) for dual-modality imaging of intracranial glioblastoma via EGFRvIII targeting

Cited by 16 publications

References 48 publications

Innovative Diagnostic Peptide‐Based Technologies for Cancer Diagnosis: Focus on EGFR‐Targeting Peptides

Innovative Diagnostic Peptide‐Based Technologies for Cancer Diagnosis: Focus on EGFR‐Targeting Peptides

Nanomaterials for Diagnosis and Treatment of Brain Cancer: Recent Updates

Recent nanotheranostics applications for cancer therapy and diagnosis: A review

Contact Info

Product

Resources

About