Engineering Approaches to Create Antibacterial Surfaces on Biomedical Implants and Devices

Tan, Ruwen; Yoo, Jin; Jang, Yeongseon

doi:10.1007/978-3-030-34475-7_14

Cited by 13 publications

(24 citation statements)

References 117 publications

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“…In recent decades, considerable focus has been placed on the creation of surface coatings to prevent initial bacterial adhesion and biofilm formation as an alternative platform since antibiotic resistance is becoming a serious threat. These antimicrobial surface coatings are mainly based on three strategies: an antifouling strategy that can significantly reduce the amount of initial bacterial attachment, an antibacterial (bactericidal) strategy, based on killing bacteria before or after coming in contact with the surface, and a third strategy based on triggered bacterial detachment [ 264 ]. Some methods combine strategies to achieve multi-functional surfaces [ 265 ].…”

Section: Antimicrobial Nanogel Surface Coatings For Biomedical Applicationsmentioning

confidence: 99%

Nanogels: A novel approach in antimicrobial delivery systems and antimicrobial coatings

Keskin

Forson

et al. 2021

Bioactive Materials

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The implementation of nanotechnology to develop efficient antimicrobial systems has a significant impact on the prospects of the biomedical field. Nanogels are soft polymeric particles with an internally cross-linked structure, which behave as hydrogels and can be reversibly hydrated/dehydrated (swollen/shrunken) by the dispersing solvent and external stimuli. Their excellent properties, such as biocompatibility, colloidal stability, high water content, desirable mechanical properties, tunable chemical functionalities, and interior gel-like network for the incorporation of biomolecules, make them fascinating in the field of biological/biomedical applications. In this review, various approaches will be discussed and compared to the newly developed nanogel technology in terms of efficiency and applicability for determining their potential role in combating infections in the biomedical area including implant-associated infections.

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Section: Antimicrobial Nanogel Surface Coatings For Biomedical Applicationsmentioning

confidence: 99%

Nanogels: A novel approach in antimicrobial delivery systems and antimicrobial coatings

Keskin

Forson

et al. 2021

Bioactive Materials

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“…Also, this could prevent the bacterial attachment and kill them via membrane destruction. The combination use of engineered antimicrobial surface and antibacterial nanoparticles (like metal oxide nanoparticles) could result in super anti-microbial nanocomposites with additive or synergistic antimicrobial effects against infections [94,95]. Regardless of the mentioned approaches and applications, the use of functionalized surfaces could be also considered as an ideal choice for intelligent food packaging markets for preventing the spoilage of food through acting as anti-microbial agents, however, more investigation is required for this application [96,97].…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Functionalization of Polymers and Nanomaterials for Biomedical Applications: Antimicrobial Platforms and Drug Carriers

et al. 2020

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The use of polymers and nanomaterials has vastly grown for industrial and biomedical sectors during last years. Before any designation or selection of polymers and their nanocomposites, it is vital to recognize the targeted applications which require these platforms to be modified. Surface functionalization to introduce the desired type and quantity of reactive functional groups to target a cell or tissue in human body is a pivotal approach to improve the physicochemical and biological properties of these materials. Herein, advances in the functionalized polymer and nanomaterials surfaces are highlighted along with their applications in biomedical fields, e.g., antimicrobial therapy and drug delivery.

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Section: Introductionmentioning

confidence: 99%

“…In the last few decades several approaches have been developed for bringing antibacterial functions to the implants as a more effective alternative to systemic delivery of antibiotics [ 21 ]. The different approaches developed aim to preserve antibacterial activity through the process of wound healing and capsulate formation [ 21 ]. Despite the highest risk of bacterial infections is during operation when the body is open to the air bacterial infections can take place at any time before capsule closing [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Layer-by-Layer Coatings for Medical Implants

2020

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The widespread occurrence of nosocomial infections and the emergence of new bacterial strands calls for the development of antibacterial coatings with localized antibacterial action that are capable of facing the challenges posed by increasing bacterial resistance to antibiotics. The Layer-by-Layer (LbL) technique, based on the alternating assembly of oppositely charged polyelectrolytes, can be applied for the non-covalent modification of multiple substrates, including medical implants. Polyelectrolyte multilayers fabricated by the LbL technique have been extensively researched for the development of antibacterial coatings as they can be loaded with antibiotics, antibacterial peptides, nanoparticles with bactericide action, in addition to being capable of restricting adhesion of bacteria to surfaces. In this review, the different approaches that apply LbL for antibacterial coatings, emphasizing those that can be applied for implant modification are presented.

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Engineering Approaches to Create Antibacterial Surfaces on Biomedical Implants and Devices

Cited by 13 publications

References 117 publications

Nanogels: A novel approach in antimicrobial delivery systems and antimicrobial coatings

Nanogels: A novel approach in antimicrobial delivery systems and antimicrobial coatings

Functionalization of Polymers and Nanomaterials for Biomedical Applications: Antimicrobial Platforms and Drug Carriers

Antibacterial Layer-by-Layer Coatings for Medical Implants

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