Engineering Biomolecular Microenvironments for Cell Instructive Biomaterials

Custódio, Catarina A.; Reis, Rui L.; Mano, João F.

doi:10.1002/adhm.201300603

Cited by 75 publications

(57 citation statements)

References 174 publications

(213 reference statements)

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“…[ 54 ] Surface modifi cation is also of great relevance in the development of bioinstructive implantable devices. [ 55 ] Since the interactions of the particles with biological moieties occur fi rstly on the surface, modifi cation of the surface chemistry may minimize the recognition by the immune system [ 56,57 ] or even promote specifi c cell adhesion (Figure 1 A). [ 58 ] The bulk of the particles also play a crucial role in their success.…”

Section: Surface and Bulk Characteristicsmentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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Particulate systems have been widely used as containers of drugs or cells with the purpose of releasing them in a particularThe search for more effi cient therapeutic strategies and diagnosis tools is a continuous challenge. Advances in understanding the biological mechanisms behind diseases and tissues regeneration have widened the fi eld of applications of particulate systems. Particles are no more just protective systems for the encapsulated drugs, but they play an active role in the success of the therapy. Moreover, particles have been explored for innovative purposes as templates for cells growth and as diagnostic tools. Until few years ago the most relevant parameters in particles formulation were the chemistry and the size. Currently, it is known that other physical characteristics can remarkably affect the performance of particulate systems. Particles with non-conventional shapes exhibit advantages due to the increasing circulation time in blood stream, less clearance by the immune system and more effi cient cell internalization and traffi cking. Creation of compartments has been found useful to control drug release, to tune the transport of substances across biological barriers, to supply the target with more than one bioactive agent or even to act as theranostic systems. It is expected that such complex shaped and compartmentalized systems improve the therapeutic outcomes and also the patient's compliance, acting as advanced devices that serve for simultaneous diagnosis and treatment of the disease, combining agents of very different features, at the same time. In this review, we overview and analyse the most recent advances in particle shape and compartmentalization and applications of newly designed particulate systems in the biomedical fi eld.

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Section: Surface and Bulk Characteristicsmentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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“…Fibrillar collagens (I, II, III, V, XI), network-forming collagen (IV, VIII, X), nonfibrillar collagens (VI, IX, XII, XV, XVIII), anchoring (VII, XVII). Both the specific nature of the extracellular matrix and the healing cascade have been inspiring the development of cell instructive tissue engineered constructs (Custodio, et al, 2014a). Those relevant cues have been incorporated into biomaterials by: i) the incorporation of human or recombinant GFs, or analogues moieties; ii) the incorporation of ECM-tissue specific compounds, or analogues moieties; iii) the use of co/multi-cultures or cell-cell contacts analogues; and iv) the use of immunomodulatory biomaterials.…”

Section: Hemostasis Inflammation Repairmentioning

confidence: 99%

Towards the design of 3D multiscale instructive tissue engineering constructs: Current approaches and trends

Oliveira

Reis

Mano

2015

Biotechnology Advances

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The design of 3D constructs with adequate properties to instruct and guide cells both in vitro and in vivo is one of the major focuses of tissue engineering. Successful tissue regeneration depends on the favorable crosstalk between the supporting structure, the cells and the host tissue so that a balanced matrix production and degradation are achieved. Herein, the major occurring events and players in normal and regenerative tissue are overviewed. These have been inspiring the selection or synthesis of instructive cues to include into the 3D constructs. We further highlight the importance of a multiscale perception of the range of features that can be included on the biomimetic structures. Lastly, we focus on the current and developing tissue-engineering approaches for the preparation of such 3D constructs: top-down, bottom-up and integrative. Bottom-up and integrative approaches present a higher potential for the design of tissue engineering devices with multiscale features and higher biochemical control than top-down strategies, and are the main focus of this review.

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“…1 The desire to engineer new tissue in the lab, encourage self-regeneration of damaged tissue, replace damaged tissue with synthetic materials or to further our understanding of cellular processes all involve the interaction of cells with artificial materials such as implants, scaffolds, biomedical devices and cell culture surfaces. A frequently encountered design element for these materials is mimicry of one or more characteristics of the natural cellular environment, with cell adhesion and survival being primary considerations alongside more specific aspects such as proliferation, migration or differentiation.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Stem Cell Fate by Nanomaterial Substrates

Mashinchian

Turner

Dalby

et al. 2015

Nanomedicine (Lond.)

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Major design aspects for novel biomaterials are driven by the desire to mimic more varied and complex properties of a natural cellular environment with man-made materials. The development of stimulus responsive materials makes considerable contributions to the effort to incorporate dynamic and reversible elements into a biomaterial. This is particularly challenging for cell-material interactions that occur at an interface (biointerfaces); however, the design of responsive biointerfaces also presents opportunities in a variety of applications in biomedical research and regenerative medicine. This review will identify the requirements imposed on a responsive biointerface and use recent examples to demonstrate how some of these requirements have been met. Finally, the next steps in the development of more complex biomaterial interfaces, including multiple stimuli responsive surfaces, surfaces of 3D objects and interactive biointerfaces will be discussed.

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Engineering Biomolecular Microenvironments for Cell Instructive Biomaterials

Cited by 75 publications

References 174 publications

Design Advances in Particulate Systems for Biomedical Applications

Design Advances in Particulate Systems for Biomedical Applications

Towards the design of 3D multiscale instructive tissue engineering constructs: Current approaches and trends

Regulation of Stem Cell Fate by Nanomaterial Substrates

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