Engineering BPQDs/PLGA nanospheres-integrated wood hydrogel bionic scaffold for combinatory bone repair and osteolytic tumor therapy

Hu, Zhichao; Lu, Jia-Qi; Hu, Annan; Dou, Yongjiang; Wang, Sheng; Su, Dihan; Ding, Wang; Lian, Ruixian; Lu, Shunyi; Xiao, Lan; Li, Yulin; Dong, Jian; Zhou, Jian; Yang, Xuyong; Jiang, Libo

doi:10.1016/j.cej.2022.137269

Cited by 31 publications

(38 citation statements)

References 77 publications

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“…Although there are many other electroactive materials, such as polyvinylidene fluoride (PVDF), graphene, carbon nanotubes, and black phosphorus, their applications are limited. For example, owing to the poor water solubility of PVDF, graphene, and carbon nanotubes, they do not bind with other materials easily [ 15 , 16 ], while the black phosphorus degrades easily owing to the inherent instability [ 17 ]. In contrast, the numerous adjustable functional groups on the surface of MXene reduced its oxidation upon storage and use as well as endowed it with high water dispersion and plasticity to form various composites and micro-structures by combining with other materials [ 15 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment

Zhang

et al. 2023

Bioactive Materials

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Section: Introductionmentioning

confidence: 99%

Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment

Zhang

et al. 2023

Bioactive Materials

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“…The type of materials includes scaffold, hydrogel, microsphere, and membrane. Most studies used black phosphorus nanosheets (BPNPs) as their core component [ 35 – 40 , 42 – 44 , 46 – 52 ], while two studies choose black phosphorus quantum dots (BPQDs) [ 41 , 45 ]. Eight studies demonstrated the bone-forming ability of their materials with the assistance of NIR laser [ 35 , 38 – 40 , 45 , 46 , 51 , 52 ].…”

Section: Resultsmentioning

confidence: 99%

“…Ages were most between six to twelve weeks old, while weights were between 200 and 400 g. The most common follow-up time was from 4 weeks to 12 weeks. Among included studies, fourteen studies used cranial bone defect to conduct their stud [ 35 – 38 , 42 – 45 , 47 – 52 ], while only four studies chose the lower limb bone defect model (tibia/femoral bone defect) [ 39 – 41 , 46 ]. Bone defect model size was equal or larger than 5 mm in eleven studies [ 35 – 37 , 42 , 44 , 45 , 47 – 50 , 52 ], while it was lower than 5 mm in seven studies [ 38 – 41 , 43 , 46 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

“…Among included studies, fourteen studies used cranial bone defect to conduct their stud [ 35 – 38 , 42 – 45 , 47 – 52 ], while only four studies chose the lower limb bone defect model (tibia/femoral bone defect) [ 39 – 41 , 46 ]. Bone defect model size was equal or larger than 5 mm in eleven studies [ 35 – 37 , 42 , 44 , 45 , 47 – 50 , 52 ], while it was lower than 5 mm in seven studies [ 38 – 41 , 43 , 46 , 51 ]. It was noteworthy that six studies did not provide their sample size [ 36 , 38 , 42 , 48 , 49 , 51 ], which contributed to these studies could not include in further meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…One included study chose magnesium ions to modify BPNPs to improve their stability [ 36 ]. However, other studies encapsulate PLGA on BPNPs/BPQDs to reduce light-introduced oxygen [ 38 , 41 ]. Hydroxyapatite (HA) is a currently widely used material, its structure is stable, not easy to degrade, and unable to provide a microenvironment of 3D micro-nano structures suitable for bone growth, showing the disadvantages of poor cell crawling and cell adhesion, as well as the difficulty of ingrowth [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

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Black phosphorous-based biomaterials for bone defect regeneration: a systematic review and meta-analysis

et al. 2022

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Critical-sized bone defects are always difficult to treat, and they are associated with a significant burden of disease in clinical practice. In recent decades, due to the fast development of biomaterials and tissue engineering, many bioinspired materials have been developed to treat large bone defects. Due to the excellent osteoblastic ability of black phosphorous (BP), many BP-based biomaterials have been developed to treat bone defects. Therefore, there are abundant studies as well as a tremendous amount of research data. It is urgent to conduct evidence-based research to translate these research data and results into validated scientific evidence. Therefore, in our present study, a qualitative systematic review and a quantitative meta-analysis were performed. Eighteen studies were included in a systematic review, while twelve studies were included in the meta-analysis. Our results showed that the overall quality of experimental methods and reports of biomaterials studies was still low, which needs to be improved in future studies. Besides, we also proved the excellent osteoblastic ability of BP-based biomaterials. But we did not find a significant effect of near-infrared (NIR) laser in BP-based biomaterials for treating bone defects. However, the quality of the evidence presented by included studies was very low. Therefore, to accelerate the clinical translation of BP-based biomaterials, it is urgent to improve the quality of the study method and reporting in future animal studies. More evidence-based studies should be conducted to enhance the quality and clinical translation of BP-based biomaterials.

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Recent Advances in Biomacromolecule‐Reinforced 2D Material (2DM) Hydrogels: From Interactions, Synthesis, and Functionalization to Biomedical Applications

Gu,

Cui,

et al. 2024

Adv Funct Materials

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Regenerative biomedicine has emerged as a forefront area in medical research, heralding a new era of therapeutic strategies. This review delineates the integration of 2D materials (2DMs) within the area of biomedical engineering, leveraging their superior physicochemical attributes for enhance biomedical outcomes. The synergistic interaction between biomacromolecules and 2DMs is explored, demonstrating their potential to mitigate the limitations inherent to each while simultaneously augmenting their beneficial properties. In particular, incorporating 2DMs into hydrogels highlights their capability to enhance the mechanical strength of hydrogels, providing a biomimetic scaffold for tissue engineering regeneration and cancer diagnosis and therapy. An overview of the synthetic methodologies are provided for 2DMs, elucidating their interaction dynamics with biomacromolecules. The review primarily concentrates on the applications of biomacromolecule‐reinforced 2DM hydrogels across various biomedical fields, including bone tissue engineering, wound healing, neural tissue engineering, cardiac tissue engineering, as well as in the delivery of drugs and genes, cancer therapy, and biosensing technologies. Finally, the review discusses the existing challenges and future outlook for developing and using biomacromolecule‐reinforced 2DM hydrogels, underlining their transformative potential in regenerative medicine.

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Engineering BPQDs/PLGA nanospheres-integrated wood hydrogel bionic scaffold for combinatory bone repair and osteolytic tumor therapy

Cited by 31 publications

References 77 publications

Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment

Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment

Black phosphorous-based biomaterials for bone defect regeneration: a systematic review and meta-analysis

Recent Advances in Biomacromolecule‐Reinforced 2D Material (2DM) Hydrogels: From Interactions, Synthesis, and Functionalization to Biomedical Applications

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