2016
DOI: 10.1073/pnas.1522985113
|View full text |Cite
|
Sign up to set email alerts
|

Engineering control of bacterial cellulose production using a genetic toolkit and a new cellulose-producing strain

Abstract: Bacterial cellulose is a strong and ultrapure form of cellulose produced naturally by several species of the Acetobacteraceae. Its high strength, purity, and biocompatibility make it of great interest to materials science; however, precise control of its biosynthesis has remained a challenge for biotechnology. Here we isolate a strain of Komagataeibacter rhaeticus (K. rhaeticus iGEM) that can produce cellulose at high yields, grow in low-nitrogen conditions, and is highly resistant to toxic chemicals. We achie… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

5
222
1
2

Year Published

2017
2017
2024
2024

Publication Types

Select...
7
2
1

Relationship

0
10

Authors

Journals

citations
Cited by 194 publications
(230 citation statements)
references
References 58 publications
5
222
1
2
Order By: Relevance
“…Synthetic biology research and applications to date have mostly been focused on the engineering of homogeneous or monoclonal designer cell populations to perform functions ranging from biocomputation 1 , to bioproduction of biomaterials 2 and chemicals 3 , to biosensing 4,5 among others. De novo implementation of genetic circuits of increasing complexity and size in living cells is an important challenge in synthetic biology.…”
mentioning
confidence: 99%
“…Synthetic biology research and applications to date have mostly been focused on the engineering of homogeneous or monoclonal designer cell populations to perform functions ranging from biocomputation 1 , to bioproduction of biomaterials 2 and chemicals 3 , to biosensing 4,5 among others. De novo implementation of genetic circuits of increasing complexity and size in living cells is an important challenge in synthetic biology.…”
mentioning
confidence: 99%
“…[121] Moreover, combinatorial approaches that are based on pathway shuffling are pursued to further explore the chemical diversity of natural products. [123] [123] …”
Section: Angewandte Chemiementioning
confidence: 99%
“…The development of genetically modified strains might improve the structural characteristics of BC and its yield. Synthetic biology strategies are now being used to optimize BC-producing strains (Florea et al, 2016).…”
Section: Challenges and Outlookmentioning
confidence: 99%