Sources of risk and uncertainty are key drivers of R&D priorities for infrastructure assets, projects, and policies. This paper describes risk factoring, which is a quantification of which climate and other diverse factors most influence the priorities of large industry and government facilities. The uncertainties addressed herein include temperature, storm intensity and frequencies, precipitation, coastal populations, sea--level rise, other environmental stressors, and factors deemed relevant by agency stakeholders. This process engages planners in four aspects: (i) a baseline multicriteria decision analysis of agency mission priorities; (ii) building of scenarios from uncertain factors including sea rise, storm frequency, erosion, land--use regulation, ecology, hydrology, etc.; (iii) priority evaluation of agency initiatives including projects, assets, geographical zones, policies, follow on studies, etc.; and (iv) concept for elicitation that supports dialogue in adaptive iterations. The results of the process have implications for a research and development roadmap for environment and ecology and other external stressors that impact the resilience of large-scale systems. The roadmap benefits from understanding which factors and combinations Headquarters 441 G St NW Washington, DC 20314 of factors are demonstrating relatively greater needs of additional investigation and modeling.