Engineering Hydrogels for Modulation of Material‐Cell Interactions

Vieira, Sílvia; Silva‐Correia, Joana; Reis, Rui L.; Oliveira, Joaquím M.

doi:10.1002/mabi.202200091

Cited by 7 publications

(5 citation statements)

References 254 publications

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“…Hydrogels are an excellent candidate for wound healing applications due to their microstructure being close to the extracellular matrix (ECM) of the tissue and providing a cell-friendly 3D environment to promote tissue regeneration. [1][2][3] Among the hydrogels, those hydrogels with the ability to react to environmental stimuli, known as smart hydrogels, have been reported to be suitable for the controlled delivery of drugs or growth factors. [4] Smart hydrogels are capable of being controlled by altering their mechanical strength and swelling behavior in response to a variety of environmental stimuli, including temperature, pH, electric or magnetic fields, and light.…”

Section: Introductionmentioning

confidence: 99%

Chitosan‐Placental ECM Composite Thermos‐Responsive Hydrogel as a Biomimetic Wound Dressing with Angiogenic Property

Azadbakht

Alizadeh

Ahovan

et al. 2022

Macromolecular Bioscience

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Attempts are being made to develop an ideal wound dressing with excellent biomechanical and biological properties. Here, a thermos-responsive hydrogel is fabricated using chitosan (CTS) with various concentrations (1%, 2.5%, and 5% w/v) of solubilized placental extracellular matrix (ECM) and 20% 𝜷-glycerophosphate to optimize a smart wound dressing hydrogel with improved biological behavior. The thermo-responsive CTS (TCTS) alone or loaded with ECMs (ECM-TCTS) demonstrate uniform morphology using SEM. TCTS and ECM1%-TCTS and ECM2.5%-TCTS show a gelation time of 5 min at 37 °C, while no gel formation is observed at 4 and 25 °C. ECM5%-TCTS forms gel at both 25 and 37 °C. The degradation and swelling ratios increase as the ECM content of the hydrogel increase. All the constructs show excellent biocompatibility in vitro and in vivo, however, the hydrogels with a higher concentration of ECM demonstrate better cell adhesion for fibroblast cells and induce expression of angiogenic factors (VEGF and VEGFR) from HUVEC. Only the ECM5%-TCTS has antibacterial activity against Acinetobacter baumannii ATCC 19606. The data obtained from the current study suggest the ECM2.5%-TCTS as an optimized smart biomimetic wound dressing with improved angiogenic properties now promises to proceed with pre-clinical and clinical investigations.

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Section: Introductionmentioning

confidence: 99%

Chitosan‐Placental ECM Composite Thermos‐Responsive Hydrogel as a Biomimetic Wound Dressing with Angiogenic Property

Azadbakht

Alizadeh

Ahovan

et al. 2022

Macromolecular Bioscience

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“…In addition, hydrogels can be designed to achieve stimuli-responsive gelation, thus facilitating their administration and allowing them to fill cavities [128]. In recent years, many studies have determined that hydrogel properties, such as stiffness, absorption capacity, or biodegradability, can be modulated according to their composition and microarchitecture design [129][130][131]. However, further studies are required to determine how these properties influence exosome interactions with different target tissues.…”

Section: Exosomes and Biomaterialsmentioning

confidence: 99%

“…biodegradability, can be modulated to their composition and microarchitecture design [129][130][131]. However, further studies are required to determine how these properties influence exosome interactions with different target tissues.…”

Section: Exosomes and Biomaterialsmentioning

confidence: 99%

Exosomes and Biomaterials: In Search of a New Therapeutic Strategy for Multiple Sclerosis

Ojeda-Hernández

Hernández-Sapiéns²,

Reza-Zaldívar

et al. 2022

Life

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Current efforts to find novel treatments that counteract multiple sclerosis (MS) have pointed toward immunomodulation and remyelination. Currently, cell therapy has shown promising potential to achieve this purpose. However, disadvantages such as poor survival, differentiation, and integration into the target tissue have limited its application. A series of recent studies have focused on the cell secretome, showing it to provide the most benefits of cell therapy. Exosomes are a key component of the cell secretome, participating in the transfer of bioactive molecules. These nano-sized vesicles offer many therapeutical advantages, such as the capacity to cross the blood-brain barrier, an enrichable cargo, and a customizable membrane. Moreover, integrating of biomaterials into exosome therapy could lead to new tissue-specific therapeutic strategies. In this work, the use of exosomes and their integration with biomaterials is presented as a novel strategy in the treatment of MS.

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“…Hydrogels synthesized from various biomaterials have been extensively studied for their ability to replicate the intricate structure of the extracellular matrix (ECM). − Their potential in mimicking the three-dimensional ECM microenvironment has effectively promoted cell adhesion, proliferation, and differentiation. , Additionally, due to the hydrogel porosity, biodegradability, and adaptive mechanical properties, it can be used as a multifaceted therapeutic mechanism for reparative SCI tools. For example, refs and mainly reported the use of hydrogel as a physical support for damaged tissue and a matrix for cell adhesion and integration, whereas refs and utilized hydrogel as a therapeutic agent’s carrier that can maintain and release their loading, and also provide biological signals to guide the reparative process. Furthermore, one of the important features of hydrogels is their ability to be injectables.…”

Section: Introductionmentioning

confidence: 99%

Application of Conductive Hydrogels on Spinal Cord Injury Repair: A Review

Shahemi

Mahat

Asri

et al. 2023

ACS Biomater. Sci. Eng.

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Spinal cord injury (SCI) causes severe motor or sensory damage that leads to long-term disabilities due to disruption of electrical conduction in neuronal pathways. Despite current clinical therapies being used to limit the propagation of cell or tissue damage, the need for neuroregenerative therapies remains. Conductive hydrogels have been considered a promising neuroregenerative therapy due to their ability to provide a pro-regenerative microenvironment and flexible structure, which conforms to a complex SCI lesion. Furthermore, their conductivity can be utilized for noninvasive electrical signaling in dictating neuronal cell behavior. However, the ability of hydrogels to guide directional axon growth to reach the distal end for complete nerve reconnection remains a critical challenge. In this Review, we highlight recent advances in conductive hydrogels, including the incorporation of conductive materials, fabrication techniques, and cross-linking interactions. We also discuss important characteristics for designing conductive hydrogels for directional growth and regenerative therapy. We propose insights into electrical conductivity properties in a hydrogel that could be implemented as guidance for directional cell growth for SCI applications. Specifically, we highlight the practical implications of recent findings in the field, including the potential for conductive hydrogels to be used in clinical applications. We conclude that conductive hydrogels are a promising neuroregenerative therapy for SCI and that further research is needed to optimize their design and application.

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Engineering Hydrogels for Modulation of Material‐Cell Interactions

Cited by 7 publications

References 254 publications

Chitosan‐Placental ECM Composite Thermos‐Responsive Hydrogel as a Biomimetic Wound Dressing with Angiogenic Property

Chitosan‐Placental ECM Composite Thermos‐Responsive Hydrogel as a Biomimetic Wound Dressing with Angiogenic Property

Exosomes and Biomaterials: In Search of a New Therapeutic Strategy for Multiple Sclerosis

Application of Conductive Hydrogels on Spinal Cord Injury Repair: A Review

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