Engineering of amphiphilic block copolymers for polymeric micellar drug and gene delivery

Xiong, Xiao-Bing; Falamarzian, Arash; Garg, Shyam M.; Lavasanifar, Afsaneh

doi:10.1016/j.jconrel.2011.04.028

Cited by 253 publications

(167 citation statements)

References 145 publications

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“…When the tumors reached about 100 mm 3 , the mice were intravenously injected every 2 days with DOX-Sol, HA-VES4/DOX, HA-VES7/DOX, and HA-VES12/DOX at a dose of DOX 10 mg/kg, respectively, and the group administered saline was used as a control. Body weights and tumor volumes (V = ab 2 /2, where "a" was the major axis and "b" the minor axis measured by slide caliper) were measured every 2 days after the administration.…”

Section: In Vivo Antitumor Effectsmentioning

confidence: 99%

The effect of dual-functional hyaluronic acid-vitamin E succinate micelles on targeting delivery of doxorubicin

Wang¹,

Guo

et al. 2016

IJN

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Section: In Vivo Antitumor Effectsmentioning

confidence: 99%

The effect of dual-functional hyaluronic acid-vitamin E succinate micelles on targeting delivery of doxorubicin

Wang¹,

Guo

et al. 2016

IJN

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“…Such assemblies, in particular spherical micelles and vesicles, have been extensively explored for the encapsulation and delivery of a wide range of biomolecules including hydrophilic and hydrophobic drugs, proteins, oligonucleotides, and imaging agents. [13][14][15] The potential of such drug delivery vehicles in biomedicine is illustrated by the fact that they not only prolong the circulation time of their payloads and protect them from premature degradation, but can also be actively or passively targeted to desired tissues and organs. 16 This results in an increase of the bioavailability of a drug and a reduction of side effects.…”

Section: Introductionmentioning

confidence: 99%

Monodisperse Cylindrical Micelles and Block Comicelles of Controlled Length in Aqueous Media

et al. 2016

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Cylindrical block copolymer micelles have shown considerable promise in various fields of biomedical research. However, unlike spherical micelles and vesicles, control over their dimensions in biologically-relevant solvents has posed a key challenge that potentially limits in depth studies and their optimisation for applications. Here, we report the preparation of cylindrical micelles of length in the wide range of 40 nm -1.10 µm in aqueous media with narrow length distributions (length polydispersities < 1.10). In our approach, an amphiphilic linear-brush block copolymer, with high potential for functionalization, was synthesized based on poly(ferrocenyldimethylsilane)-b-poly(allyl glycidyl ether) (PFS-b-PAGE) decorated with triethylene glycol (TEG), abbreviated as PFS-b-(PEO-g-TEG). PFS-b-(PEO-g-TEG) cylindrical micelles of controlled length with low polydispersities were prepared in N,N-dimethylformamide using small seed initiators via living crystallization-driven self-assembly. Successful dispersion of these micelles into aqueous media was achieved by dialysis against deionized water. Furthermore, B-A-B amphiphilic triblock comicelles with PFS-b-poly(2-vinylpyridine) (P2VP) as hydrophobic "B" blocks and hydrophilic PFS-b-(PEO-g-TEG) "A" segments were prepared and their hierarchical self-assembly in aqueous media studied. It was found that superstructures formed depend on the length of the hydrophobic blocks. Quaternization of P2VP was shown to cause the disassembly of the superstructures, resulting in the first examples of water-soluble cylindrical multi-block comicelles. We also demonstrate the ability of the triblock comicelles with quaternized terminal segments to complex DNA and, thus, to potentially function as gene vectors.

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Apart from the conventional linear copolymers and wellknown spherical symmetry of dendrimers, linear-dendritic copolymers are a unique class of macromolecules with unique solid and solution state properties. They are largely dependent on the chemistry, size and solvophilicity gradient between the respective blocks, and they have attracted interest due to their potential use as drug and gene delivery devices because of their ability to form micelles with critical micelle concentration (CMC) values well below the CMC values of traditional surfactants.…”

Section: Introductionmentioning

confidence: 99%

pH-responsive dendritic polyrotaxane drug-polymer conjugates forming nanoparticles as efficient drug delivery system for cancer therapy

Kang

Zhang

et al. 2015

Polym. Chem.

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a Self-assembly of stimuli-responsive polymeric nanoparticles have attracted great attention in recent years due to their prospective biological applications. This paper developed a novel pH-sensitive amphiphilic dendritic polyrotaxane drug-polymer conjugate by covalently linking doxorubicin (DOX) and dendritic polyrotaxane via a pH-responsible hydrazone bond with 1.84 wt% (weight percent) of DOX. The drugpolymer conjugate was amphiphilic and could be self-assembled to micelles (PR-g-DOX micelles) in an aqueous solution. The globular morphology and compact micelles with a diameter of around 110 nm were observed by SEM and TEM. Moreover, the micelles showed a significantly faster DOX release at mildly acidic pH of 6.0 and 5.0 and almost no burst release at the physiological pH of 7.4. Notably, it was confirmed that this micelle could efficiently deliver DOX to the nuclei of the tumor cells, which led to a much greater cytotoxic effects in the A549 cancer cells than the parent DOX. In vivo results revealed better drug tolerability of PR-g-DOX micelles and a higher in vivo efficacy without any increase in the toxicity of the PR-g-DOX micelles. Furthermore, the maximum tolerated dose (MTD) results showed that PRg-DOX micelles showed an excellent safety profile with a two-fold higher MTD (10 mg kg −1 DOX) than that of free DOX (5 mg kg −1 DOX). We are convinced that the PR-g-DOX micelle has tremendous potentials for targeted cancer therapy.

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Engineering of amphiphilic block copolymers for polymeric micellar drug and gene delivery

Cited by 253 publications

References 145 publications

The effect of dual-functional hyaluronic acid-vitamin E succinate micelles on targeting delivery of doxorubicin

The effect of dual-functional hyaluronic acid-vitamin E succinate micelles on targeting delivery of doxorubicin

Monodisperse Cylindrical Micelles and Block Comicelles of Controlled Length in Aqueous Media

pH-responsive dendritic polyrotaxane drug-polymer conjugates forming nanoparticles as efficient drug delivery system for cancer therapy

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