Engineering of carbonyl reductase for asymmetric reduction of difficult-to-reduce ketone tetrahydrofuran-3-one

Lin, Ya‐Ping; Su, Bing-Mei; Lin, Juan

doi:10.1016/j.mcat.2023.113466

Molecular Catalysis

2023

DOI: 10.1016/j.mcat.2023.113466

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Engineering of carbonyl reductase for asymmetric reduction of difficult-to-reduce ketone tetrahydrofuran-3-one

Ya‐Ping Lin

Bing-Mei Su

Juan Lin

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2024

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Rational design of short‐chain dehydrogenase/reductase for enantio‐complementary synthesis of chiral 1,2‐diols by successive hydroxymethylation and reduction of aldehydes

Ren,

Su,

et al. 2024

Biotech & Bioengineering

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Enantiopure 1,2‐diols are widely used in the production of pharmaceuticals, cosmetics, and functional materials as essential building blocks or bioactive compounds. Nevertheless, developing a mild, efficient and environmentally friendly biocatalytic route for manufacturing enantiopure 1,2‐diols from simple substrate remains a challenge. Here, we designed and realized a step‐wise biocatalytic cascade to access chiral 1,2‐diols starting from aromatic aldehyde and formaldehyde enabled by a newly mined benzaldehyde lyase from Sphingobium sp. combined with a pair of tailored‐made short‐chain dehydrogenase/reductase from Pseudomonas monteilii (PmSDR‐MuR and PmSDR‐MuS) capable of producing (R)‐ and (S)‐1‐phenylethane‐1,2‐diol with 99% ee. The planned biocatalytic cascade could synthesize a series of enantiopure 1,2‐diols with a broad scope (16 samples), excellent conversions (94%–99%), and outstanding enantioselectivity (up to 99% ee), making it an effective technique for producing chiral 1,2‐diols in a more environmentally friendly and sustainable manner.

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Rational design of short‐chain dehydrogenase/reductase for enantio‐complementary synthesis of chiral 1,2‐diols by successive hydroxymethylation and reduction of aldehydes

Ren,

Su,

et al. 2024

Biotech & Bioengineering

View full text Add to dashboard Cite

show abstract

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Engineering of carbonyl reductase for asymmetric reduction of difficult-to-reduce ketone tetrahydrofuran-3-one

Cited by 1 publication

References 34 publications

Rational design of short‐chain dehydrogenase/reductase for enantio‐complementary synthesis of chiral 1,2‐diols by successive hydroxymethylation and reduction of aldehydes

Rational design of short‐chain dehydrogenase/reductase for enantio‐complementary synthesis of chiral 1,2‐diols by successive hydroxymethylation and reduction of aldehydes

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