Engineering of Composite Particles for Drug Delivery Using Supercritical Fluid Technology

Shekunov, Boris Y.; Chattopadhyay, Pratibhash; Seitzinger, Jeff

doi:10.1021/bk-2006-0924.ch015

Cited by 8 publications

(2 citation statements)

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“…Thus, the use of supercritical CO 2 in particle production is very convenient from several points of view. Encapsulation of drugs in biodegradable materials in general is an active field of investigation in which new developments are continually reported [201][202][203][204][205]. Recently, CO 2 was used as a carrier for impregnating a polymer (disc or particles) with a drug from solution; CO 2 plasticizes the polymer, the allowing the diffusion rate of the drug to be controlled.…”

Section: Particle Productionmentioning

confidence: 99%

Supercritical carbon dioxide as a green solvent for processing polymer melts: Processing aspects and applications

Nalawade

Picchioni

Janssen

2006

Progress in Polymer Science

574

181

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Supercritical carbon dioxide (CO 2) is well established for use as a processing solvent in polymer applications such as polymer modification, formation of polymer composites, polymer blending, microcellular foaming, particle production and polymerization. Its gas-like diffusivity and liquid-like density in the supercritical phase allow replacing conventional, often noxious, solvents with supercritical CO 2. Though only a few polymers are soluble in supercritical CO 2 , it is quite soluble in many molten polymers. CO 2 dissolution in a polymer has been interpreted physically but FT-IR studies lead to an explanation in terms of weak interactions between basic and acidic sites. Various experimental methods and equations of state are available to measure or predict the solubility of CO 2. Dissolved CO 2 causes a considerable reduction in the viscosity of molten polymer, a very important property for the applications stated above. CO 2 mainly acts as a plasticizer or solvent when contacted with a polymer. Gas solubility and viscosity reduction can be predicted theoretically from purecomponent properties. In this review, experimental and theoretical studies of solubility and viscosity of several polymer melts are discussed in detail. Detailed attention is also given to recently reported applications along with aspects related to polymer processing.

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Section: Particle Productionmentioning

confidence: 99%

Supercritical carbon dioxide as a green solvent for processing polymer melts: Processing aspects and applications

Nalawade

Picchioni

Janssen

2006

Progress in Polymer Science

574

181

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“…This organic solvent is dispersed into the aqueous phase by a homogenizer, using a certain surfactant for stabilization. Then, the emulsion is bombed until atomization through a nozzle and submitted to an extraction of the organic solvent by scCO 2 in countercurrent flux with consequent solidification of lipid droplets and collection of aqueous suspension of solid lipid particles [ 77 , 78 ].…”

Section: Reviewmentioning

confidence: 99%

Characteristics of lipid micro- and nanoparticles based on supercritical formation for potential pharmaceutical application

et al. 2013

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The interest of the pharmaceutical industry in lipid drug delivery systems due to their prolonged release profile, biocompatibility, reduction of side effects, and so on is already known. However, conventional methods of preparation of these structures for their use and production in the pharmaceutical industry are difficult since these methods are usually multi-step and involve high amount of organic solvent. Furthermore, some processes need extreme conditions, which can lead to an increase of heterogeneity of particle size and degradation of the drug. An alternative for drug delivery system production is the utilization of supercritical fluid technique. Lipid particles produced by supercritical fluid have shown different physicochemical properties in comparison to lipid particles produced by classical methods. Such particles have shown more physical stability and narrower size distribution. So, in this paper, a critical overview of supercritical fluid-based processes for the production of lipid micro- and nanoparticles is given and the most important characteristics of each process are highlighted.

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Spectroscopic and chromatographic characterization of triflusal delivery systems prepared by using supercritical impregnation technologies

Argemí

López‐Periago

Domingo

et al. 2008

Journal of Pharmaceutical and Biomedical Analysis

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Engineering of Composite Particles for Drug Delivery Using Supercritical Fluid Technology

Cited by 8 publications

References 0 publications

Supercritical carbon dioxide as a green solvent for processing polymer melts: Processing aspects and applications

Supercritical carbon dioxide as a green solvent for processing polymer melts: Processing aspects and applications

Characteristics of lipid micro- and nanoparticles based on supercritical formation for potential pharmaceutical application

Spectroscopic and chromatographic characterization of triflusal delivery systems prepared by using supercritical impregnation technologies

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