Engineering plasmonic nanorod arrays for colon cancer marker detection

Dodson, Stephanie; Cao, Cuong; Zaribafzadeh, Hamed; Li, Shuzhou; Xiong, Qihua

doi:10.1016/j.bios.2014.07.083

Cited by 30 publications

(14 citation statements)

References 47 publications

(47 reference statements)

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“…Dodson et al developed a periodic Au nanorod array for the detection of single nucleotide polymorphisms (SNP) in a gene that is frequently occurring in early stages of colon cancer with an LOD under 10 nm [63]. However, the study shows preliminary results, as it did not include any type of microfluidic cell, it involves static measurements, and no real samples (or spiked complex samples) have been assessed so far.…”

Section: Bioanalytical and Clinical Applicationsmentioning

confidence: 99%

Recent advances in nanoplasmonic biosensors: applications and lab-on-a-chip integration

et al. 2016

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Abstract:Motivated by the recent progress in the nanofabrication field and the increasing demand for cost-effective, portable, and easy-to-use point-of-care platforms, localized surface plasmon resonance (LSPR) biosensors have been subjected to a great scientific interest in the last few years. The progress observed in the research of this nanoplasmonic technology is remarkable not only from a nanostructure fabrication point of view but also in the complete development and integration of operative devices and their application. The potential benefits that LSPR biosensors can offer, such as sensor miniaturization, multiplexing opportunities, and enhanced performances, have quickly positioned them as an interesting candidate in the design of lab-on-a-chip (LOC) optical biosensor platforms. This review covers specifically the most significant achievements that occurred in recent years towards the integration of this technology in compact devices, with views of obtaining LOC devices. We also discuss the most relevant examples of the use of the nanoplasmonic biosensors for real bioanalytical and clinical applications from assay development and validation to the identification of the implications, requirements, and challenges to be surpassed to achieve fully operative devices.

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Section: Bioanalytical and Clinical Applicationsmentioning

confidence: 99%

Recent advances in nanoplasmonic biosensors: applications and lab-on-a-chip integration

et al. 2016

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“…88 As an emerging future technology, nanoantennas can be used for early detection of cancerous tumours 243,244 which will lead to the development of effective cancer treatment. Few recent works have shown that biosensing based on surface plasmon resonance (SPR) has proved to be effective in label-free tumor detection [245][246][247][248] and can be used to detect a single molecule of an early stage tumor. Currently, research and development are in progress in making a nanoantenna based SPR biosensor which will be able to detect cancer cells at an early stage.…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

Nanoantenna enhanced terahertz interaction of biomolecules

Adak

Tripathi

2019

Analyst

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Terahertz time-domain spectroscopy (THz-TDS) is a non-invasive, non-contact and label-free technique for biological and chemical sensing as THz-spectra is less energetic and lies in the characteristic vibration frequency regime of proteins and DNA molecules. However, THz-TDS is less sensitive for detection of micro-organisms of size equal to or less than λ/100 (where, λ is wavelength of incident THz wave) and, molecules in extremely low concentrated solutions (like, a few femtomolar). After successful high-throughput fabrication of nanostructures, nanoantennas and metamaterials were found to be indispensable in enhancing the sensitivity of conventional THz-TDS. These nanostructures lead to strong THz field enhancement which when in resonance with absorption spectrum of absorptive molecules, causing significant changes in the magnitude of the transmission spectrum, therefore, enhancing the sensitivity and allowing detection of molecules and biomaterials in extremely low concentrated solutions. Hereby, we review the recent developments in ultra-sensitive and selective nanogap biosensors. We have also provided an in-depth review of various high-throughput nanofabrication techniques. We also discussed the physics behind the field enhancements in sub-skin depth as well as sub-nanometer sized nanogaps. We introduce finite-difference time-domain (FDTD) and molecular dynamics (MD) simulations tools to study THz biomolecular interactions. Finally, we provide a comprehensive account of nanoantenna enhanced sensing of viruses (like, H1N1) and biomolecules such as artificial sweeteners which are addictive and carcinogenic. CONTENTS

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“…Various types of planar resonators, including split ring resonators (SRR), nanorods, crescents, and pyramids have been reported to have sensitivities of 100–300 nm per RIU and FOM of ≈2 in the visible frequency range. Higher sensitivity is achievable in self‐assembled metal nanoparticles due to their lower damping loss and negligible interaction with the substrate .…”

Section: Introductionmentioning

confidence: 99%

Hybrid Transverse–Longitudinal Modes for High Figure‐of‐Merit Localized Plasmonic Refractometric Sensing in the Visible Spectrum

Soehartono

Tobing

Mueller

et al. 2020

Advanced Optical Materials

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integration of mid-IR resonators with 2D materials has been shown to enhance sensing performance. [14] For the practicality of these applications, it is often desirable to implement the platform with a simple and cost-effective optical configuration, using inexpensive light sources and photodetectors operating in the visible spectrum. The practical aspect of localized surface plasmon (LSP)-based sensing lies in the mode excitation that can be carried out in a microscope setting, in contrast to its integrated optics and surface plasmon polariton counterparts that require complex optical configurations to meet their phase-matching conditions. [15,16] The performance of a plasmon-based sensor is gauged by the sensitivity (S) and the figure of merit (FOM), with the former describing the susceptibility of the plasmonic confinement to the refractive index changes and the latter, dependent on the resonance Q factor, describing the sensing resolution. The sensitivity has been shown to increase linearly with the resonance wavelength (λ R ), that is, S∝λ R [17,18] indicating that sensitivity progressively decreases toward the visible frequency range. This presents a dilemma in the realization of practical and cost-effective sensing platform, where high sensitivity and high FOM are the desirable parameters for visible frequency operation.Various types of planar resonators, including split ring resonators (SRR), [19] nanorods, [20,21] crescents, [22] and pyramids [23] have been reported to have sensitivities of 100-300 nm per RIU and FOM of ≈2 in the visible frequency range. Higher sensitivity is achievable in self-assembled metal nanoparticles due to their lower damping loss and negligible interaction with the substrate. [24,25] However, such an approach is not preferable in the context of a practical sensing platform requiring precise control of nanoantenna dimensions and placements. Another approach for improving sensing parameters is through planar multi-cavity configurations that allow bright and dark modes to interfere and produce a narrow Fano resonance, [26][27][28][29] where the cancellation of radiative loss gives rise to linewidth reduction and consequently higher Q factors. Sensing based on Fano resonance has been reported with structures such as The nanoscale confinement of plasmonic fields, coupled with their high susceptibility to refractive index changes, makes localized surface plasmons (LSPs) an excellent platform for rapid and label-free sensing. However, the small spatial overlap of the LSP fields with the adsorbed analyte dictates the sensitivity and figure of merit (FOM) of LSP-based sensing. The linear dependence of sensitivity on resonance wavelength, coupled with the dependence of FOM on the achievable resonance Q factor, leads to a sensitivity of ≈100-300 nm per RIU and FOM < 5 for gold-based LSP resonance in the visible range. This presents a dilemma for the realization of a practical sensing platform that requires high sensitivity and high FOM in the visible spectrum. Higher sensitivity and reso...

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Engineering plasmonic nanorod arrays for colon cancer marker detection

Cited by 30 publications

References 47 publications

Recent advances in nanoplasmonic biosensors: applications and lab-on-a-chip integration

Recent advances in nanoplasmonic biosensors: applications and lab-on-a-chip integration

Nanoantenna enhanced terahertz interaction of biomolecules

Hybrid Transverse–Longitudinal Modes for High Figure‐of‐Merit Localized Plasmonic Refractometric Sensing in the Visible Spectrum

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