2016
DOI: 10.1002/btm2.10031
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Engineering responsive supramolecular biomaterials: Toward smart therapeutics

Abstract: Engineering materials using supramolecular principles enables generalizable and modular platforms that have tunable chemical, mechanical, and biological properties. Applying this bottom‐up, molecular engineering‐based approach to therapeutic design affords unmatched control of emergent properties and functionalities. In preparing responsive materials for biomedical applications, the dynamic character of typical supramolecular interactions facilitates systems that can more rapidly sense and respond to specific … Show more

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Cited by 56 publications
(27 citation statements)
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References 195 publications
(222 reference statements)
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“…3B ), including several efforts designed to respond to disease-relevant stimuli 5-7. In terms of supramolecular materials, common stimuli alter material swelling or promote bond rupture through hydrolysis or enzymatic action 77. For host-guest systems particularly, the ability to precisely control the formation of a complex and link complex formation to biologically relevant or biologically compatible triggers has obvious application in improving therapeutic precision.…”
Section: Integrating Stimuli-responsive Function In the Applicatiomentioning
confidence: 99%
“…3B ), including several efforts designed to respond to disease-relevant stimuli 5-7. In terms of supramolecular materials, common stimuli alter material swelling or promote bond rupture through hydrolysis or enzymatic action 77. For host-guest systems particularly, the ability to precisely control the formation of a complex and link complex formation to biologically relevant or biologically compatible triggers has obvious application in improving therapeutic precision.…”
Section: Integrating Stimuli-responsive Function In the Applicatiomentioning
confidence: 99%
“…The sol–gel transition at 37 °C enables easy encapsulation of cells and their minimally invasive administration in vivo. [94,95] Conversely, the gel–sol transition at physiological temperature can be used to release biomolecules or cells within the defect site. Incorporation of growth factors along with cells during encapsulation and their subsequent controlled release enables continuous supply of growth factor(s) to control the fate/phenotype of the differentiating cells.…”
Section: Physical Stimuli-responsive Hydrogelsmentioning
confidence: 99%
“…Non-covalent assemblies based on relatively weak supramolecular interactions are less likely to tolerate significant structural variation and can exhibit poor mechanical integrity. 6,[17][18][19][20][21][22] Developing a robust and chemically general macrocycle assembly strategy will enable broad explorations into nanotube design, their emergent properties, and stimuli-responsive [23][24][25][26] or even out-of-equilibrium assembly processes. [27][28][29][30] We recently found that the protonation of imine-linked macrocycles triggers strong electrostatic and solvophobic interactions that drive the formation of high-aspect ratio nanotubes.…”
Section: Introductionmentioning
confidence: 99%