Engineering skeletal muscle: Building complexity to achieve functionality

Mihaly, Eszter; Altamirano, Dallas E.; Tuffaha, Sami H.; Grayson, Warren L.

doi:10.1016/j.semcdb.2021.04.016

Cited by 17 publications

(9 citation statements)

References 103 publications

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“…Our understanding of the signaling interplay between myogenic cells (and other cells) with components of the ECM and basement membrane adherent to cells (Pozzi et al 2017 ) through receptors, proteolysis, and unmasking of cryptic sites in ECM proteins (Clause and Barker 2013 ; Brown et al 2015 ; Barker and Engler 2017 ; Yeh et al 2021 ) has shown major recent advances. These new ideas have brought biomechanics, tissue engineering, and nano-scale three-dimensional scaffold production into the realm of therapeutics for muscle regeneration (Turner and Badylak 2012 ; Choi et al 2018 ; Dunn et al 2019 ; Marcinczyk et al 2019 ; Patel et al 2019 ; Baiguera et al 2020 ; Gilbert-Honick and Grayson 2020 ; Mihaly et al 2021 ), promising prospects for implantable volumes of muscle tissue that will promote the ingrowth of vessels and nerves (Laumonier and Menetrey 2016 ; Gilbert-Honick and Grayson 2020 ). Interstitial fibroblasts between muscle fibers, produce many components of the extracellular matrix (ECM) and wrap around collagen cables (Gillies and Lieber 2011 ; Gillies et al 2017 ).…”

Section: The Current Contextmentioning

confidence: 99%

Key concepts in muscle regeneration: muscle “cellular ecology” integrates a gestalt of cellular cross-talk, motility, and activity to remodel structure and restore function

Anderson

2021

Eur J Appl Physiol

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This review identifies some key concepts of muscle regeneration, viewed from perspectives of classical and modern research. Early insights noted the pattern and sequence of regeneration across species was similar, regardless of the type of injury, and differed from epimorphic limb regeneration. While potential benefits of exercise for tissue repair was debated, regeneration was not presumed to deliver functional restoration, especially after ischemia–reperfusion injury; muscle could develop fibrosis and ectopic bone and fat. Standard protocols and tools were identified as necessary for tracking injury and outcomes. Current concepts vastly extend early insights. Myogenic regeneration occurs within the environment of muscle tissue. Intercellular cross-talk generates an interactive system of cellular networks that with the extracellular matrix and local, regional, and systemic influences, forms the larger gestalt of the satellite cell niche. Regenerative potential and adaptive plasticity are overlain by epigenetically regionalized responsiveness and contributions by myogenic, endothelial, and fibroadipogenic progenitors and inflammatory and metabolic processes. Muscle architecture is a living portrait of functional regulatory hierarchies, while cellular dynamics, physical activity, and muscle–tendon–bone biomechanics arbitrate regeneration. The scope of ongoing research—from molecules and exosomes to morphology and physiology—reveals compelling new concepts in muscle regeneration that will guide future discoveries for use in application to fitness, rehabilitation, and disease prevention and treatment.

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Section: The Current Contextmentioning

confidence: 99%

Key concepts in muscle regeneration: muscle “cellular ecology” integrates a gestalt of cellular cross-talk, motility, and activity to remodel structure and restore function

Anderson

2021

Eur J Appl Physiol

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“…New research hotspots such as tissue engineering might bring a breakthrough to this certain field; scaffolds and bioengineered adipose tissue are being used as a promising substitute for autologous skin flaps for defect reconstruction 46 . While the survival of engineered tissue structures also depends on adequate vascularization, challenges remain in inducing vascularization for long‐term function 47 .…”

Section: Discussionmentioning

confidence: 99%

“…29 New research hotspots such as tissue engineering might bring a breakthrough to this certain field; scaffolds and bioengineered adipose tissue are being used as a promising substitute for autologous skin flaps for defect reconstruction. 46 While the survival of engineered tissue structures also depends on adequate vascularization, challenges remain in inducing vascularization for longterm function. 47 Many high-impact factor articles are also mainly related to tissue engineering technologies, reflecting the importance of translational medicine in flap repair and its future strategy and development direction.…”

Section: Hotspot Analysis Of Research Pertaining To Vascularization A...mentioning

confidence: 99%

Angiogenesis and flap‐related research: A bibliometric analysis

Tong

Xiao

et al. 2023

International Wound Journal

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Adequate blood supply, a prerequisite for flap survival after grafting, makes angiogenesis of the flap the biggest problem to be solved. Researches have been conducted around vascularisation in correlation with flap grafting. However, bibliometric analyses systematically examining this research field are lacking. As such, we herein sought to conduct comprehensive comparative analyses of the contributions of different researchers, institutions, and countries to this research space in an effort to identify trends and hotspots in angiogenesis and vascularisation in the context of flap grafting. Publications pertaining to angiogenesis and vascularisation in the context of flap grafting were retrieved from the Web of Science Core Collection. References were then analysed and plotted using Microsoft Excel 2019, VOSviewer, and CiteSpace V. In total, 2234 papers that were cited 40 048 times (17.63 citations/paper) were included in this analysis. The greatest number of studies were from the United States, with these studies exhibiting both the highest number of citations (13 577) and the greatest overall H‐index (60). For The institutions that published the greatest number of studies were WENZHOU MEDICAL UNIVERSITY (681), while UNIVERSITY OF ERLANGEN NUREMBERG has the highest number of citations (1458), and SHANGHAI JIAO TONG UNIVERSITY holds the greatest overall H‐index (20). The greatest number of studies in this research space were published by Gao WY, while Horch RE was the most commonly cited researcher in the field. The VOS viewer software clustered relevant keywords into three clusters, with clusters 1, 2, 3, and 4 corresponding to studies in which the keywords ‘anatomy’, ‘survival’, ‘transplantation’, ‘therapy’ most frequently appeared. The most promising research hotspot‐related terms in this field included ‘autophagy’, ‘oxidative stress’, ‘ischemia/reperfusion injury’, which exhibited a most recent average appearing year (AAY) of 2017 and after. Generally speaking, the results of this analysis indicate that the number of articles exploring angiogenesis and flap‐related research has risen steadily, with the United States and China being the two countries publishing the greatest proportion of studies in this field. The overall focus of these studies has shifted away from ‘infratest and tissue engineering’ towards ‘mechanisms’. In the future, particular attention should be paid to emerging research hotspots, which include ‘ischemia/reperfusion injury’ and treatments for promoting vascularization, such as ‘platelet‐rich plasma’. In light of these findings, funding agencies should continue increasing their investment in the exploration of the concrete mechanisms and interventional therapeutic relevance of angiogenesis during flap transplantation.

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“…Nevertheless, this practice causes additional damage to the donor site, and the recipient site may develop complications such as tendon adhesion, scarring, hematoma, infection, insufficient blood perfusion, and lack of innervation. [5] For severe skeletal muscle injury, to restore its structure and function is still a clinical challenge to be solved. obtain a deeper understanding of how ASC-exos promote muscle regeneration.…”

Section: Introductionmentioning

confidence: 99%

“…Plastic surgeons must use autologous vascularized muscle tissue to repair muscle defects and improve appearance and function. Nevertheless, this practice causes additional damage to the donor site, and the recipient site may develop complications such as tendon adhesion, scarring, hematoma, infection, insufficient blood perfusion, and lack of innervation [5] . For severe skeletal muscle injury, to restore its structure and function is still a clinical challenge to be solved.…”

Section: Introductionmentioning

confidence: 99%