Engineering the bilayer: Emerging genetic tool kits for mechanistic lipid biology

Moore, William M.; Milshteyn, Daniel; Tsai, Yi‐Ting; Budin, Itay

doi:10.1016/j.cbpa.2021.05.013

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Lipid Engineering1

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2022

2024

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Cited by 3 publications

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“…Over the past several decades, complementary synthetic biology and metabolic engineering techniques have been applied to functional studies of lipids ( Moore et al, 2021 ). Nano-injection of lipids has been successful in directly delivering different phospholipids, including PE, PC, and LPC, into intracellular membranes ( Aref et al, 2020 ).…”

Section: Lipid Engineeringmentioning

confidence: 99%

Dynamic Progress in Technological Advances to Study Lipids in Aging: Challenges and Future Directions

2022

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Lipids participate in all cellular processes. Diverse methods have been developed to investigate lipid composition and distribution in biological samples to understand the effect of lipids across an organism’s lifespan. Here, we summarize the advanced techniques for studying lipids, including mass spectrometry-based lipidomics, lipid imaging, chemical-based lipid analysis and lipid engineering and their advantages. We further discuss the limitation of the current methods to gain an in-depth knowledge of the role of lipids in aging, and the possibility of lipid-based therapy in aging-related diseases.

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Section: Lipid Engineeringmentioning

confidence: 99%