Engineering the pH-Sensitivity of the Graphene and Carbon Nanotube Based Nanomedicines in Smart Cancer Therapy by Grafting Trimetyl Chitosan

Khoshoei, Azadeh; Ghasemy, Ebrahim; Poustchi, Fatemeh; Shahbazi, Mohammad‐Ali; Maleki, Reza

doi:10.1007/s11095-020-02881-1

Cited by 37 publications

(24 citation statements)

References 43 publications

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“…In addition, nanoparticles showed enhanced binding with cancer cells and slight or negligible binding to normal cells. Khoshoei et al, 2020, have recently highlighted the applications of molecular dynamic simulation in pH-responsive and stimuli-responsive drug delivery systems for cancer chemotherapy [300]. The approach of molecular dynamic simulation can play a key role in predicting the maximum therapeutic effects through novel drug delivery systems with the least side effects and various other biomedical applications.…”

Section: Molecular Dynamics (Md) Simulations Associated With Stimuli-mentioning

confidence: 99%

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

Rahim

Jan

Khan

et al. 2021

Cancers

133

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The tumor-specific targeting of chemotherapeutic agents for specific necrosis of cancer cells without affecting the normal cells poses a great challenge for researchers and scientists. Though extensive research has been carried out to investigate chemotherapy-based targeted drug delivery, the identification of the most promising strategy capable of bypassing non-specific cytotoxicity is still a major concern. Recent advancements in the arena of onco-targeted therapies have enabled safe and effective tumor-specific localization through stimuli-responsive drug delivery systems. Owing to their promising characteristic features, stimuli-responsive drug delivery platforms have revolutionized the chemotherapy-based treatments with added benefits of enhanced bioavailability and selective cytotoxicity of cancer cells compared to the conventional modalities. The insensitivity of stimuli-responsive drug delivery platforms when exposed to normal cells prevents the release of cytotoxic drugs into the normal cells and therefore alleviates the off-target events associated with chemotherapy. Contrastingly, they showed amplified sensitivity and triggered release of chemotherapeutic payload when internalized into the tumor microenvironment causing maximum cytotoxic responses and the induction of cancer cell necrosis. This review focuses on the physical stimuli-responsive drug delivery systems and chemical stimuli-responsive drug delivery systems for triggered cancer chemotherapy through active and/or passive targeting. Moreover, the review also provided a brief insight into the molecular dynamic simulations associated with stimuli-based tumor targeting.

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Section: Molecular Dynamics (Md) Simulations Associated With Stimuli-mentioning

confidence: 99%

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

Rahim

Jan

Khan

et al. 2021

Cancers

133

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“…[142][143][144][145] Chitosan with anticancer activity and as a pH sensitive polymer has been widely employed in the synthesis of polymergraphene hybrids. [146][147][148] The produced multifunctional scaffolds have exhibited high loading capacities and functional binding sites for different types of drugs and targeting ligands. [147][148][149] Moreover, graphene-chitosan platforms have been widely studied as a pH-sensitive nanovehicle for the targeted release of drugs into cancer cells.…”

Section: Graphene-polymer Platforms In Drug Deliverymentioning

confidence: 99%

Functionalized Graphene Platforms for Anticancer Drug Delivery

Sattari¹,

Adeli²,

Beyranvand³

et al. 2021

IJN

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Two-dimensional nanomaterials are emerging as promising candidates for a wide range of biomedical applications including tissue engineering, biosensing, pathogen incapacitation, wound healing, and gene and drug delivery. Graphene, due to its high surface area, photothermal property, high loading capacity, and efficient cellular uptake, is at the forefront of these materials and plays a key role in this multidisciplinary research field. Poor water dispersibility and low functionality of graphene, however, hamper its hybridization into new nanostructures for future nanomedicine. Functionalization of graphene, either by covalent or non-covalent methods, is the most useful strategy to improve its dispersion in water and functionality as well as processability into new materials and devices. In this review, recent advances in functionalization of graphene derivatives by different (macro)molecules for future biomedical applications are reported and explained. In particular, hydrophilic functionalization of graphene and graphene oxide (GO) to improve their water dispersibility and physicochemical properties is discussed. We have focused on the anticancer drug delivery of polyfunctional graphene sheets.

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“…This type of bonds can be formed not only between the molecules of the same substance, but also between two different molecules. One H atom and the pair of non-common electron molecules participate to form a H-bond [54][55][56].…”

Section: Hydrogen Interactions Of Urea and Fullerenesmentioning

confidence: 99%

Molecular insight into optimizing the N- and P-doped fullerenes for urea removal in wearable artificial kidneys

Jahromi

Zandi

Khedri

et al. 2021

J Mater Sci: Mater Med

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Urea is the result of the breakdown of proteins in the liver, the excess of which circulates in the blood and is adsorbed by the kidneys. However, in the case of kidney diseases, some products, specifically urea, cannot be removed from the blood by the kidneys and causes serious health problems. The end-stage renal disease (ESRD) patients are not able to purify their blood, which endangers their life. ESRD patients require dialysis, a costly and difficult method of urea removal from the blood. Wearable artificial kidneys (WAKs) are consequently designed to remove the waste from blood. Regarding the great amount of daily urea production in the body, WAKs should contain strong and selective urea adsorbents. Fullerenes—which possess fascinating chemical properties—have been considered herein to develop novel urea removal adsorbents. Molecular dynamics (MD) has enabled researchers to study the interaction of different materials and can pave the way toward facilitating the development of wearable devices. In this study, urea adsorption by N-doped fullerenes and P-doped fullerenes were assessed through MD simulations. The urea adsorption was simulated by five samples of fullerenes, with phosphorous and different nitrogen dopant contents. For comparing the urea adsorption capacity in the performed simulations, detailed characteristics—including the energy analysis, radius of gyration, radial distribution function (RDF), root-mean-square fluctuation (RMSD), and H-bond analyses were investigated. It had been determined that the fullerene containing 8% nitrogen—with the highest reduction in the radius of gyration, the maximum RDF, a high adsorption energy, and a high number of hydrogen bonds—adsorbs urea more efficiently.

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Engineering the pH-Sensitivity of the Graphene and Carbon Nanotube Based Nanomedicines in Smart Cancer Therapy by Grafting Trimetyl Chitosan

Cited by 37 publications

References 43 publications

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

Functionalized Graphene Platforms for Anticancer Drug Delivery

Molecular insight into optimizing the N- and P-doped fullerenes for urea removal in wearable artificial kidneys

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