Engineering three-dimensional structures using bio-inspired dopamine and strontium on titanium for biomedical application

Liu, Yen-Ting; Kung, Kuan Chen; Yang, Chih Hai; Lee, Tzer Min; Lui, Truan-Sheng

doi:10.1039/c4tb00822g

Cited by 25 publications

(15 citation statements)

References 37 publications

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“…In addition, the CaP nanoparticles with biocompatible ions had a positive effect for stimulating the preosteoblast cells. In particular, Ca 2+ and Sr 2+ ions appeared to highly contribute to enhanced cell attachment and viability . The Ba 2+ ‐ion‐treated HAc–CaP hydrogels supported better cell attachment, showing a high degree of cell polarization and proliferation, which is attributed to their good hydrophilicity .…”

Section: Resultsmentioning

confidence: 96%

Dual‐Crosslinking of Hyaluronic Acid–Calcium Phosphate Nanocomposite Hydrogels for Enhanced Mechanical Properties and Biological Performance

Jeong

Sun

Kim

2017

Macro Materials & Eng

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Herein, a facile approach for synthesizing mechanically enhanced nanocomposite hydrogels via a dual‐crosslinking process is described. Additional ionic crosslinking using various cations is introduced after an in situ precipitation process for hydroxyapatite immobilization in hyaluronic acid hydrogels (HAc–CaP). Ca2+, Ba2+, and Sr2+ ions exhibit the highest efficiencies in reinforcing the mechanical properties of HAc–CaP hydrogels. In addition, the dual‐crosslinked HAc–CaP hydrogels promote the biological responses of preosteoblast cells, which exhibit highly stretched shapes and greatly enhanced proliferation. Furthermore, the nanocomposite hydrogels achieve enhanced bioactivity by supporting osteogenic differentiation. Thus, enhancement on both the mechanical and biological properties of hyaluronic‐acid‐based nanocomposite hydrogels is achieved through this dual‐crosslinking process, extending the potential application of these materials to hard tissue engineering.

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Section: Resultsmentioning

confidence: 96%

Dual‐Crosslinking of Hyaluronic Acid–Calcium Phosphate Nanocomposite Hydrogels for Enhanced Mechanical Properties and Biological Performance

Jeong

Sun

Kim

2017

Macro Materials & Eng

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“…The pre-osteoblastic cell lines (MC3T3-E1, ATCC®CRL-2593TM) that were used in this study were also used in a previous study [22]. The MC3T3-E1 cell lines are effective models for studying in vitro osteoblast differentiation, and particularly extracellular matrix signaling.…”

Section: Cell Test In Vitromentioning

confidence: 99%

Nano/Micro Hierarchical Bioceramic Coatings for Bone Implant Surface Treatments

et al. 2020

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Bone implants with surface modifications that promote the physiological activities of osteoblasts are the first step for osseointegration in bone repair. Hydroxyapatite is the main inorganic component in mammal bones and teeth, and nanoscaled hydroxyapatite promotes the adhesion of osteoblastic cells. In this study, we created a nano/micro hierarchical structure using micro-arc oxidation coatings and hydrothermal treatments at 150 °C, 175 °C, and 200 °C for 2, 6, 12, and 24 h. After undergoing hydrothermal treatment for 24 h, CaTiO3 began forming regular-shaped crystals at the surface at 175 °C. In order to decrease the CaTiO3 formations and increase the apatite fabrication, a shorter time of hydrothermal treatment was required at 175 °C. There was still surface damage on samples treated for 6 h at 175 °C; however, the nano/micro hierarchical structures were formed in 2 h at 175 °C. The normalized alkaline phosphatase (ALP) activities of the MC3T3-E1 cells with micro-arc oxidation (MAO) coatings and nano/micro hierarchical bioceramics coatings were 4.51 ± 0.26 and 7.36 ± 0.51 μmol p-NP/mg protein (*** P value of <0.001), respectively. The MC3T3-E1 cells with coatings showed highly statistically significant results in terms of the ALP activity. This proposed nano/micro hierarchical structure promoted cell proliferation and osteogenic differentiation of the osteoblast MC3T3-E1 cells. This study realized a promising nano system for osseointegration via bone implant surface treatments, which can promote the physiological activities of osteoblasts.

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“…In addition, a porous biomedical implant allows an excellent environment for body fluids and drugs to flow effectively through the porous network. This therefore offers better opportunities for the body tissue to grow and enhance osseointegration and bone regeneration by providing a good interfacial bonding between the implant and bone [18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

Stainless steel with tailored porosity using canister-free hot isostatic pressing for improved osseointegration implants

et al. 2017

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Engineering three-dimensional structures using bio-inspired dopamine and strontium on titanium for biomedical application

Abstract: Poly(dopamine) films facilitate the initial attachment and proliferation of cells. Cell differentiation is enhanced by the release of strontium from the coatings.

Cited by 25 publications

References 37 publications

Dual‐Crosslinking of Hyaluronic Acid–Calcium Phosphate Nanocomposite Hydrogels for Enhanced Mechanical Properties and Biological Performance

Dual‐Crosslinking of Hyaluronic Acid–Calcium Phosphate Nanocomposite Hydrogels for Enhanced Mechanical Properties and Biological Performance

Nano/Micro Hierarchical Bioceramic Coatings for Bone Implant Surface Treatments

Stainless steel with tailored porosity using canister-free hot isostatic pressing for improved osseointegration implants

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