Engineering tubular bone using mesenchymal stem cell sheets and coral particles

Wang, Geng; Ma, Dongyang; Yan, Xingrong; Liu, Liangqi; Cui, Jihong; Xie, Xin; Li, Hongmin; Chen, Fulin

doi:10.1016/j.bbrc.2013.03.034

Cited by 28 publications

(23 citation statements)

References 20 publications

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“…32 Once an osteoinducing signal is added either in the form of osteogenic cells or growth factors, bone formation is initiated. 32,33,34 The structural characteristics and the degree of bone formation was found to be linked to the resorption of the calcium carbonate corals. 32, 35 Such approach can result in the construction of material of predesigned shape with structure similar to the native bone.…”

Section: Animal Studiesmentioning

confidence: 99%

“…32, 35 Such approach can result in the construction of material of predesigned shape with structure similar to the native bone. 33,36 This strategy can be utilized to fabricate pre-vascularized tissue engineered bone grafts. 37 Such grafts can have a predetermined shape, organized internal vascular network with a vascular pedicle attached to the graft.…”

Section: Animal Studiesmentioning

confidence: 99%

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Is there a role of coral bone substitutes in bone repair?

Pountos

Giannoudis

2016

Injury

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Xenogeneic bone graft materials are an alternative to autologous bone grafting. Among such implants, coralline-derived bone grafts substitutes have a long track record as safe, biocompatible and osteoconductive graft materials. In this review, we present the available literature surrounding their use with special focus on the commercially available graft materials. Corals thanks to their chemical and structural characteristics similar to those of the human cancellous bone have shown great potential but clinical data presented to date is ambiguous with both positive and negative outcomes reported.Correct formulation and design of the graft to ensure adequate osteo-activity and resorption appears intrinsic to a successful outcome.

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Section: Animal Studiesmentioning

confidence: 99%

Section: Animal Studiesmentioning

confidence: 99%

Is there a role of coral bone substitutes in bone repair?

Pountos

Giannoudis

2016

Injury

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“…The authors observed that following the in vitro incubation period, the bone graft still exhibit a tubular shape, sufficient radiological density and suitable values of compressive strength. The in vivo results demonstrated that the cell sheets had a good osteogenic capacity and after 8 weeks of implantation a mature tissue with a similar mineral density as the one of mouse spine [153].…”

Section: Coral-derived Bone Grafts Substitutesmentioning

confidence: 87%

“…The authors concluded that a partially mineralised and osteogenic cell sheet could vitalise a coral scaffold for bone formation [152]. Following a similar strategy, Geng et al [153] combined MSCs sheets and coral particles. Coral particles were incorporated on the surface of confluent rabbit MSCs forming a cell sheet.…”

Section: Coral-derived Bone Grafts Substitutesmentioning

confidence: 99%

Synthetic and Marine-Derived Porous Bone Graft Substitutes

Neto¹,

Ferreira²

2018

Preprint

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Bone is a dynamic tissue with the capacity of repair and regeneration in specific conditions. Nevertheless, due to the increased incidence of bone disorders, the need of bone grafts has been growing over the past decades and the development of a bone graft with optimal properties remains a clinical challenge. This review addresses the bone properties (morphology, composition and their repair and regeneration capacity) and then is focused on the potential strategies for bone repair and regeneration. It describes the requirements for designing a suitable scaffold material, types of materials (polymers, ceramics and composites) and techniques to obtain the porous structures (additive manufacturing techniques/robocasting or derived from marine skeletons) for bone tissue engineering applications. The main objective of this review is to gather the knowledge on the materials and methods for the production of scaffolds for bone tissue engineering and highlight that natural materials, namely the marine skeletons represent a promising alternative.

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“…, (Ag + ) , (Schlosser et al, 2013;Zhang et al, 2010;. Geng et al (2013) in vitro , de Peppo et al (2013) , --, . ,…”

Section: 해양무척추동물 유래 의생명공학적 활용 가능 소재unclassified

Biomedical Materials for Regenerating Bone Tissue Utilizing Marine Invertebrate

Oh¹,

Jung²

2015

Korean Journal of Fisheries and Aquatic Sciences

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Tissue engineering is an emerging, innovative technology to improve or replace the biological functions of damaged tissues and organs. Scaffolds are important materials for tissue engineering as they support cell attachment, migration, and differentiation. Marine sponges naturally contain scaffolds formed by extracellular matrix proteins (collagen and sponging) and strengthened by a siliceous or calcium carbonate skeleton. Coral skeletons are also derived naturally formed by essential calcium carbonate in the form of aragonite, and are similar to human bone. In addition, collagen extracted from jellyfish is a biosafe alternative to bovine and porcine collagen and gained attention as a potential source for tissue engineering. Moreover, cuttlefish bone is an excellent calcium source and can be used to generate bio-synthetic calcium phosphate. It has become a natural candidate for biomimetic scaffolds. This review describes the use of natural products derived from marine invertebrates for applications in bone tissue engineering based on studies from 2008 to 2014.

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Engineering tubular bone using mesenchymal stem cell sheets and coral particles

Cited by 28 publications

References 20 publications

Is there a role of coral bone substitutes in bone repair?

Is there a role of coral bone substitutes in bone repair?

Synthetic and Marine-Derived Porous Bone Graft Substitutes

Biomedical Materials for Regenerating Bone Tissue Utilizing Marine Invertebrate

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