2017
DOI: 10.1016/j.jbiotec.2017.07.008
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Engineering yeasts as platform organisms for cannabinoid biosynthesis

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Cited by 70 publications
(86 citation statements)
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References 27 publications
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“…As most aPTases from plants are integral membrane proteins (Carvalho, Hansen, Kayser, Carlsen, & Stehle, ), this key enzyme also represents a major challenge in the development of a microbial platform for the synthesis of PAs as its functional heterologous expression is required to actively catalyze the prenylation reaction. As such, many proof of concept studies reconstituting PAs biosynthetic pathways have been done in eukaryotic cells (yeast; Z. Li et al, ; Zirpel, Degenhardt, Martin, Kayser, & Stehle, ), and even these efforts have been limited to whole‐cell biotransformations with low product yields.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…As most aPTases from plants are integral membrane proteins (Carvalho, Hansen, Kayser, Carlsen, & Stehle, ), this key enzyme also represents a major challenge in the development of a microbial platform for the synthesis of PAs as its functional heterologous expression is required to actively catalyze the prenylation reaction. As such, many proof of concept studies reconstituting PAs biosynthetic pathways have been done in eukaryotic cells (yeast; Z. Li et al, ; Zirpel, Degenhardt, Martin, Kayser, & Stehle, ), and even these efforts have been limited to whole‐cell biotransformations with low product yields.…”
Section: Introductionmentioning
confidence: 99%
“…As such, many proof of concept studies reconstituting PAs biosynthetic pathways have been done in eukaryotic cells (yeast; Z. Li et al, 2017;Zirpel, Degenhardt, Martin, Kayser, & Stehle, 2017), and even these efforts have been limited to whole-cell biotransformations with low product yields.…”
mentioning
confidence: 99%
“…, Zirpel et al. ), providing an alternative means of production of these products. Metabolically engineered canola lines, which are enriched in omega‐3 fatty acids, and have better outcomes for public health, are already commercially available for human and animal consumption (Waltz ).…”
Section: The Loss Of Kelp Forests and The Rise Of Synthetic Biologymentioning
confidence: 99%
“…The structure of THCA synthase (Uniprot ID Q8GTB6, PDB ID 3VTE) was elucidated by Kuroki and his associates in 2012 2 . Cannabidiolic acid synthase was functionally expressed in yeast by Stehle and his associates in 2017 3 . The known cannabinoid synthases share approximately 80% sequence identity.…”
Section: Figurementioning
confidence: 99%