Enhanced antibacterial potential of berberine via synergism with chitosan nanoparticles

Dash, Sonali Prava; Kumar, Manish; Pareek, Nidhi

doi:10.1016/j.matpr.2020.05.506

Cited by 14 publications

(5 citation statements)

References 22 publications

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“…The BSF chitosan demonstrated stronger activity against P. aeruginosa and gave a diameter of inhibition of 21 mm, which was lower compared to the findings of [53,54], with diameters of 27 mm and 12 mm, respectively [53,54]. Chitosan from BSF demonstrated notable antibacterial activity against B. subtilis, which was consistent with previous studies [55]. The chitosan of BSF also showed stronger antifungal properties, as demonstrated by greater inhibition of C. albicans; this is similar to the findings of [47,56,57].…”

Section: Antimicrobial Properties Of Chitosan Against Pathogenic Microbessupporting

confidence: 87%

Antimicrobial Activity of Chemically and Biologically Treated Chitosan Prepared from Black Soldier Fly (Hermetia illucens) Pupal Shell Waste

et al. 2021

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Globally, the broad-spectrum antimicrobial activity of chitin and chitosan has been widely documented. However, very little research attention has focused on chitin and chitosan extracted from black soldier fly pupal exuviae, which are abundantly present as byproducts from insect-farming enterprises. This study presents the first comparative analysis of chemical and biological extraction of chitin and chitosan from BSF pupal exuviae. The antibacterial activity of chitosan was also evaluated. For chemical extraction, demineralization and deproteinization were carried out using 1 M hydrochloric acid at 100 °C for 2 h and 1 M NaOH for 4 h at 100 °C, respectively. Biological chitin extraction was carried out by protease-producing bacteria and lactic-acid-producing bacteria for protein and mineral removal, respectively. The extracted chitin was converted to chitosan via deacetylation using 40% NaOH for 8 h at 100 °C. Chitin characterization was done using FTIR spectroscopy, while the antimicrobial properties were determined using the disc diffusion method. Chemical and biological extraction gave a chitin yield of 10.18% and 11.85%, respectively. A maximum chitosan yield of 6.58% was achieved via chemical treatment. From the FTIR results, biological and chemical chitin showed characteristic chitin peaks at 1650 and 1550 cm−1—wavenumbers corresponding to amide I stretching and amide II bending, respectively. There was significant growth inhibition for Escherichia coli, Bacillus subtilis,Pseudomonas aeruginosa,Staphylococcus aureus, and Candida albicans when subjected to 2.5 and 5% concentrations of chitosan. Our findings demonstrate that chitosan from BSF pupal exuviae could be a promising and novel therapeutic agent for drug development against resistant strains of bacteria.

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Section: Antimicrobial Properties Of Chitosan Against Pathogenic Microbessupporting

confidence: 87%

Antimicrobial Activity of Chemically and Biologically Treated Chitosan Prepared from Black Soldier Fly (Hermetia illucens) Pupal Shell Waste

et al. 2021

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“…BBR has potent antimicrobial properties against bacteria, viruses, protozoa, fungi, and yeasts 37 , which supports its antibiotic action toward harmful pathogenic bacteria 38 , 39 . Previous studies aimed to develop a natural antimicrobial nano-particulate drug delivery formulation that could enhance the sensitivity of the antimicrobial drugs 40 , 41 .…”

Section: Discussionmentioning

confidence: 92%

Preparation, physicochemical characterization, and bioactivity evaluation of berberine-entrapped albumin nanoparticles

Younis

Saleh

El-Rahman

et al. 2022

Sci Rep

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Berberine (BBR) is an isoquinoline alkaloid with several clinical therapeutic applications. Its low water solubility, absorption, and cellular bioavailability diminish BBR's therapeutic efficacy. In this study, BBR was encapsulated into bovine serum albumin nanoparticles (BSA NPs) core to reduce BBR limitations and enhance its clinical therapeutic properties. Several physicochemical characterization tools, such as Dynamic Light Scattering and Ultraviolet–Visible spectroscopic measurements, field emission transmission electron microscopy surface morphology, Fourier transforms infrared spectroscopy, thermal stability analysis, and releasing studies, were used to evaluate the BBR-BSA NPs. Compared to BBR, BBR-BSA nanoparticles demonstrated superior free radical scavenging and antioxidant capacities, anti-hemolytic and anticoagulant efficacies, and antimicrobial activities, as demonstrated by the findings of the in vitro studies. Furthermore, a stressed pancreatic rat model was induced using a high-fat, high-sucrose diet plus carbon tetrachloride injection. The in vivo results revealed that BBR-BSA NPs substantially restored peripheral glucose metabolism and insulin sensitivity. Oral administration of BBR-BSA NPs also improved pancreatic β-cells homeostasis, upregulated pancreatic antioxidant mechanisms, inhibited oxidants generation, and attenuated oxidative injury in the stressed pancreatic tissues. In conclusion, our in vitro and in vivo results confirmed that BBR-BSA NPs demonstrated more potent antioxidant properties and restored pancreatic homeostasis compared to BBR.

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“…Nanoparticulate chitosan has also been used in a synergistic combination with the antimicrobial alkaloid berberine demonstrating the enhanced antibacterial activity, although still only at an MIC of 50 µg/mL against both Staphylococcus aureus and Bacillus subtilis [25]. While berberine has a number of modes of action [13], an understanding of the molecular basis of this enhancement still needs further study but it is an interesting observation.…”

Section: Nanoparticulates In Combinationsmentioning

confidence: 99%

An Update Review of Approaches to Multiple Action-Based Antibacterials

Bremner

2023

Antibiotics

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Many approaches are being pursued to address the major global health challenge posed by the increasing resistance of pathogenic bacteria to antibacterial agents. One of the promising approaches being investigated includes the design and development of multiple action-based small-molecule antibacterials. Aspects of this broad area have been reviewed previously, and recent developments are addressed in this update review covering the literature mainly over the past three years. Considerations encompassing drug combinations, single-molecule hybrids and prodrugs are summarised in regard to the intentional design and development of multiple-action agents with a focus on potential triple or greater activities in bacteria. The hope for such single agents or combinations of single agents is that resistance development will be significantly hindered, and they may be useful in tackling bacterial disease caused by both resistant and non-resistant bacteria.

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Enhanced antibacterial potential of berberine via synergism with chitosan nanoparticles

Cited by 14 publications

References 22 publications

Antimicrobial Activity of Chemically and Biologically Treated Chitosan Prepared from Black Soldier Fly (Hermetia illucens) Pupal Shell Waste

Antimicrobial Activity of Chemically and Biologically Treated Chitosan Prepared from Black Soldier Fly (Hermetia illucens) Pupal Shell Waste

Preparation, physicochemical characterization, and bioactivity evaluation of berberine-entrapped albumin nanoparticles

An Update Review of Approaches to Multiple Action-Based Antibacterials

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