Enhanced antibody response to ovalbumin coupled to poly-dispersed acid functionalized single walled carbon nanotubes

Dutt, Taru; Saxena, Rajiv K.

doi:10.1016/j.imlet.2019.11.003

Cited by 8 publications

(4 citation statements)

References 47 publications

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“…B cells incubated with acid-functionalized single-walled carbon nanotubes (OVA-AF-SWCNT) internalized more OVA than the B cells incubated with free OVA with a higher antibody response was highest in the group where ovalbumin coupled to AF-SWCNTs was used for immunization comparable Freund's adjuvant [ 114 ].…”

Section: Cbm Vaccines and Immunotherapiesmentioning

confidence: 99%

Nanotechnology in the COVID-19 era: Carbon-based nanomaterials as a promising solution

Papi

Spirito

Palmieri

2023

Carbon

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Section: Cbm Vaccines and Immunotherapiesmentioning

confidence: 99%

Nanotechnology in the COVID-19 era: Carbon-based nanomaterials as a promising solution

Papi

Spirito

Palmieri

2023

Carbon

View full text Add to dashboard Cite

“…In addition, this photo/chemo/immunotherapy synergistic strategy induced the shifting of TAM from M2 to M1, while reducing the amount of Tregs in TME, contributing to an elevated antitumor effect for melanoma treatment. Besides, various f -CNTs were reported to deliver vaccines like ovalbumin (OVA) or siRNA to protect them from degradation for enhanced immunotherapy effects, which shows great research interest and clinical value to treat many cancers [ 134 – 136 ].…”

Section: Carbon Nanotubes In Cancer Treatmentmentioning

confidence: 99%

Insights on functionalized carbon nanotubes for cancer theranostics

et al. 2021

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Despite the exciting breakthroughs in medical technology, cancer still accounts for one of the principle triggers of death and conventional therapeutic modalities often fail to attain an effective cure. Recently, nanobiotechnology has made huge advancement in cancer therapy with gigantic application potential because of their ability in achieving precise and controlled drug release, elevating drug solubility and reducing adverse effects. Carbon nanotubes (CNTs), one of the most promising carbon-related nanomaterials, have already achieved much success in biomedical field. Due to their excellent optical property, thermal and electronic conductivity, easy functionalization ability and high drug loading capacity, CNTs can be applied in a multifunctional way for cancer treatment and diagnosis. In this review, we will give an overview of the recent progress of CNT-based drug delivery systems in cancer theranostics, which emphasizes their targetability to intracellular components of tumor cells and extracellular elements in tumor microenvironment. Moreover, a detailed introduction on how CNTs penetrate inside the tumor cells to reach their sites of action and achieve the therapeutic effects, as well as their diagnostic applications will be highlighted. Graphic Abstract

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“…x FOR PEER REVIEW 10 of 20 As discussed above for other nanostructures, also in the case of CNTs, oxidation is often the first step for their biological application to achieve good dispersibility in water, and this is typically obtained by acid treatment, as shown in a recent study where oxidized CNTs demonstrated antibacterial activity [177]. The process can be carried out also in a microwave oven [178]. However, this kind of treatment requires extensive washings, and greener alternatives include gas-phase methods that use radical oxygen species generated by UV irradiation in air [179].…”

Section: Carbon Nanotubes (Cnts)mentioning

confidence: 99%

“…Alternatively, the carboxylic acid groups can be covalently coupled to biomolecules in water, as shown for ovalbumin to boost immune response to antigen presentation for vaccine development [178]. With an analogous approach, oxidized CNTs were coupled to dopamine to promote the mineralization with hydroxyapatite, and CNT electronic properties were exploited to achieve directional alignment through agarose gel electrophoresis to form scaffolds with collagen, which promoted the healing of bone defects in vivo [184].…”

Section: Carbon Nanotubes (Cnts)mentioning

confidence: 99%

Green Approaches to Carbon Nanostructure-Based Biomaterials

et al. 2021

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The family of carbon nanostructures comprises several members, such as fullerenes, nano-onions, nanodots, nanodiamonds, nanohorns, nanotubes, and graphene-based materials. Their unique electronic properties have attracted great interest for their highly innovative potential in nanomedicine. However, their hydrophobic nature often requires organic solvents for their dispersibility and processing. In this review, we describe the green approaches that have been developed to produce and functionalize carbon nanomaterials for biomedical applications, with a special focus on the very latest reports.

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Enhanced antibody response to ovalbumin coupled to poly-dispersed acid functionalized single walled carbon nanotubes

Cited by 8 publications

References 47 publications

Nanotechnology in the COVID-19 era: Carbon-based nanomaterials as a promising solution

Nanotechnology in the COVID-19 era: Carbon-based nanomaterials as a promising solution

Insights on functionalized carbon nanotubes for cancer theranostics

Green Approaches to Carbon Nanostructure-Based Biomaterials

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