Enhanced antiinflammatory capacity of a
            <i>Lactobacillus plantarum</i>
            mutant synthesizing modified teichoic acids

Grangette, Corinne; Nutten, Sophie; Palumbo, Emmanuelle; Morath, Siegfried; Hermann, Corinna; Dewulf, Joëlle; Pot, Bruno; Hartung, Thomas; Hols, Pascal; Mercenier, Annick

doi:10.1073/pnas.0504084102

Cited by 398 publications

(405 citation statements)

References 49 publications

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“…102 In addition, the ability of various LAB strains to induce a high ratio of IL-10/IL-12 production in human PBMCs correlated with their capacity to provide signifi cant protection from TNBSinduced colitis. [108][109][110] Increasing the production of IL-10 by lamina propria T cells was also found to be an important mechanism in the ability of VSL#3 to reduce the severity of recurrent colitis induced by readministration of TNBS. 111 This induction of IL-10 was essential for the expansion of a population of regulatory T cells that was identifi ed as a critical mediator of the amelioration of colitis and possessed characteristics of "natural" Tregs.…”

Section: Probiotics In Infl Ammatory Diseases Of the Bowelmentioning

confidence: 99%

Probiotics and immunity

et al. 2009

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Probiotics are defi ned as live microorganisms that, when administered in adequate amounts, confer a health benefi t on the host, including the gastrointestinal tract. While this benefi cial effect was originally thought to stem from improvements in the intestinal microbial balance, there is now substantial evidence that probiotics can also provide benefi ts by modulating immune functions. In animal models, probiotic supplementation is able to provide protection from spontaneous and chemically induced colitis by downregulating infl ammatory cytokines or inducing regulatory mechanisms in a strain-specifi c manner. In animal models of allergen sensitization and murine models of asthma and allergic rhinitis, orally administered probiotics can straindependently decrease allergen-specifi c IgE production, in part by modulating systemic cytokine production. Certain probiotics have been shown to decrease airway hyperresponsiveness and infl ammation by inducing regulatory mechanisms. Promising results have been obtained with probiotics in the treatment of human infl ammatory diseases of the intestine and in the prevention and treatment of atopic eczema in neonates and infants. However, the fi ndings are too variable to allow fi rm conclusions as to the effectiveness of specifi c probiotics in these conditions.

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Section: Probiotics In Infl Ammatory Diseases Of the Bowelmentioning

confidence: 99%

Probiotics and immunity

et al. 2009

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“…In the previous report, the quality and level of D-alanine substitution in LTA were shown to be key factors for cytokine induction (5,20). Therefore, we examined whether pLTA-induced tolerance is dependent on the D-alanine contents of LTA.…”

Section: The Acyl Group Of Plta Played An Important Role In the Inhibmentioning

confidence: 99%

Lipoteichoic Acid Isolated from Lactobacillus plantarum Inhibits Lipopolysaccharide-Induced TNF-α Production in THP-1 Cells and Endotoxin Shock in Mice

Kim

Gim

et al. 2008

The Journal of Immunology

111

108

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In this study, the effect of Lactobacillus plantarum lipoteichoic acid (pLTA) on LPS-induced MAPK activation, NF-κB activation, and the expression of TNF-α and IL-1R-associated kinase M (IRAK-M) was examined. The expression of the pattern recognition receptor and the survival rate of mice were also examined. pLTA pretreatment inhibited the phosphorylation of ERK, JNK, and p38 kinase. It also inhibited the degradation of IκBα and IκBβ, as well as the activation of the LPS-induced TNF-α factor in response to subsequent LPS stimulation. These changes were accompanied by the suppression of the LPS-induced expression of TLR4, NOD1, and NOD2, and the induction of IRAK-M, with a concurrent reduction of TNF-α secretion. Furthermore, the overexpression of pattern recognition receptors such as TLR4, NOD1, and NOD2 and the degradation of IRAK-M by transient transfection were found to reinstate the production of TNF-α after LPS restimulation. In addition, the i.p. injection of pLTA suppressed fatality, and decreased the level of TNF-α in the blood, in LPS-induced endotoxin shock mice. In conclusion, these data extend our understanding of the pLTA tolerance mechanism, which is related to the inhibition of LPS-induced endotoxin shock, and suggest that pLTA may have promise as a new therapeutic agent for LPS-induced septic shock.

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“…However, bacterial components such as glycolipids may be important for signalling between some probiotics and host. For example, certain Lactobacillus species in which capsular lipoteichoic acid is absent or D-alanine depleted, switch from being pro-to anti-inflammatory 16,17 in vivo and in vitro, and, with respect to visceral pain in rats, to being antinociceptive 18 .…”

mentioning

confidence: 99%

Bacteroides fragilis polysaccharide A is necessary and sufficient for acute activation of intestinal sensory neurons

et al. 2013

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Symbionts or probiotics are known to affect the nervous system. To understand the mechanisms involved, it is important to measure sensory neuron responses and identify molecules responsible for this interaction. Here we test the effects of adding Lactobacillus rhamnosus (JB-1) and Bacteroides fragilis to the epithelium while making voltage recordings from intestinal primary afferent neurons. Sensory responses are recorded within 8 s of applying JB-1 and excitability facilitated within 15 min. Bacteroides fragilis produces similar results, as does its isolated, capsular exopolysaccharide, polysaccharide A. Lipopolysaccharide-free polysaccharide A completely mimics the neuronal effects of the parent organism. Experiments with a mutant Bacteroides fragilis devoid of polysaccharide A shows that polysaccharide A is necessary and sufficient for the neuronal effects. Complex carbohydrates have not been reported before as candidates for such signalling between symbionts and the host. These observations indicate new neuronal targets and invite further study of bacterial carbohydrates as inter-kingdom signalling molecules between beneficial bacteria and sensory neurons.

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Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids

Cited by 398 publications

References 49 publications

Probiotics and immunity

Probiotics and immunity

Lipoteichoic Acid Isolated from Lactobacillus plantarum Inhibits Lipopolysaccharide-Induced TNF-α Production in THP-1 Cells and Endotoxin Shock in Mice

Bacteroides fragilis polysaccharide A is necessary and sufficient for acute activation of intestinal sensory neurons

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