Enhanced antimicrobial performance of cloisite 30B/poly (ε-caprolactone) over cloisite 30B/poly ( l -lactic acid) as evidenced by structural features

Babu, Snigdha S.; Kalarikkal, Nandakumar; Thomas, Sabu

doi:10.1016/j.clay.2017.12.003

Cited by 29 publications

(14 citation statements)

References 33 publications

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“…PCL degrades slowly by the hydrolysis process, caused by its high crystallinity and hydrophobic nature. Among the various biological, ecological, and medical applications, PCL has been implemented as implantable biomaterials, biodegradable materials, and microparticles for drug delivery [24][25][26][27][28][29][30][31]. Additionally, the effect of carbon nanotubes and silver nanoparticles on the biological properties of PCL were tested [30].…”

Section: Introductionmentioning

confidence: 99%

Research of Binary and Ternary Composites Based on Selected Aliphatic or Aliphatic–Aromatic Polymers, 5CB or SWCN toward Biodegradable Electrodes

et al. 2020

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The main goal of this paper was to study the optical, electrical, and thermal properties of hybrid composites based on biodegradable polymers (L,D-poly(lactic acid), polycaprolactone or Ecoflex®), single walled carbon nanotubes (SWCN), and 4′-pentyl-4-biphenylcarbonitrile (5CB). The biodegradable polymers’ binary and ternary compositions were analyzed in detail by ultraviolet and visible (UV–Vis) spectroscopy taking into consideration their chemical structure and interactions with 5CB and SWCN. Differential scanning calorimetry (DSC) studies of the created hybrid layers showed thermal stability and changes in glass transition temperature and melting point in comparison to neat polymers, depending on the chemical structure of the polymer used and the type of composition. Morphology of the created layers were investigated by atomic force and polarizing microscopy. The static contact angle measurements of a water drop showed that all of the neat polymer layers were hydrophobic with angle values ranging from 108° to 115°. In addition, in the case of the Ecoflex® layers, both with and without additives, a rapid sorption of the deposited water drop was observed. Finally, a simple device with poly(ethylene terephthalate) (PET)/indium tin oxide (ITO)/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS)/poly [[4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b′]dithiophene-2,6-diyl][3-fluoro-2-[(2-ethylhexyl)carbonyl]thieno[3,4-b]thiophenediyl]] (PTB7): [6,6]-phenyl-C71-butyric acid methyl ester (PC70BM)/Ag/biodegradable polymer:SWCN architecture was constructed and tested using an infrared (IR) thermographic camera to investigate the surface defects on the created hybrid layers. Increasing the SWCN admixture from 0.01 to 0.5% significantly improved the conductivity only in the case of L,D-poly(lactic acid):SWCN (10:0.5), for which above 5 V, a current with a resistance of 3030.7 Ω could be measured. In order to use the created layers as flexible electrodes, the first experiments were carried out with an admixture of SWCN and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) as conductive compounds.

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Section: Introductionmentioning

confidence: 99%

Research of Binary and Ternary Composites Based on Selected Aliphatic or Aliphatic–Aromatic Polymers, 5CB or SWCN toward Biodegradable Electrodes

et al. 2020

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“…Therefore, the cell growth plateau observed in PLA/CLO 5% scaffolds after 4 days could be related to the release of the alkylammonium salt intercalated into the clays into the medium that can thus affect the cell growth. In fact, it is well known that the alkyl ammonium surfactant present in Cloisite 30B can be released in a liquid medium also when incorporated in polymer matrices and it is primarily responsible for its microbicidal properties 38 …”

Section: Discussionmentioning

confidence: 99%

“…In fact, it is well known that the alkyl ammonium surfactant present in Cloisite 30B can be released in a liquid medium also when incorporated in polymer matrices and it is primarily responsible for its microbicidal properties. 38 …”

Section: Discussionmentioning

confidence: 99%

“…In tissue engineering applications, various types of inorganic nanofiller such as carbon nanotubes, 33 graphene, 26 and hydroxyapatite 27 have been used to produce polymer/inorganic biocomposite fibers, leading to high‐performance nanofibrous mats. In this context, nanosilica and nanoclay are one of the most investigated nanofillers for polymer matrix due to several interesting properties including low thermal conductivity, chemically inertness, and non‐toxicity 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 that can be exploited for tissue engineering purposes and other biomedical applications. 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 …”

Section: Introductionmentioning

confidence: 99%

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Physical and biological properties of electrospun poly(d,l‐lactide)/nanoclay and poly(d,l‐lactide)/nanosilica nanofibrous scaffold for bone tissue engineering

Lopresti

Pavia

Ceraulo

et al. 2021

J Biomedical Materials Res

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Electrospun scaffolds exhibiting high physical performances with the ability to support cell attachment and proliferation are attracting more and more scientific interest for tissue engineering applications. The inclusion of inorganic nanoparticles such as nanosilica and nanoclay into electrospun biopolymeric matrices can meet these challenging requirements. The silica and clay incorporation into polymeric nanofibers has been reported to enhance and improve the mechanical properties as well as the osteogenic properties of the scaffolds. In this work, for the first time, the physical and biological properties of polylactic acid (PLA) electrospun mats filled with different concentrations of nanosilica and nanoclay were evaluated and compared. The inclusion of the particles was evaluated through morphological investigations and Fourier transform infrared spectroscopy. The morphology of nanofibers was differently affected by the amount and kind of fillers and it was correlated to the viscosity of the polymeric suspensions. The wettability of the scaffolds, evaluated through wet contact angle measurements, slightly increased for both the nanocomposites. The crystallinity of the systems was investigated by differential scanning calorimetry highlighting the nucleating action of both nanosilica and nanoclay on PLA. Scaffolds were mechanically characterized with tensile tests to evaluate the reinforcing action of the fillers. Finally, cell culture assays with pre‐osteoblastic cells were conducted on a selected composite scaffold in order to compare the cell proliferation and morphology with that of neat PLA scaffolds. Based on the results, we can convince that nanosilica and nanoclay can be both considered great potential fillers for electrospun systems engineered for bone tissue regeneration.

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“…Some frequently investigated organic antimicrobials intercalated into clay structures include quaternary ammonium salts. In their studies, authors Babu et al [ 30 , 31 ], with the aim of developing antibacterial and antibiofilm surfaces, focused on the preparation of PCL/Cloisite 30B nanocomposites by solvent casting. The nanocomposite films prepared in this way showed antibacterial activity and acted as excellent barriers against the penetration of surrounding microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Development of Novel Thin Polycaprolactone (PCL)/Clay Nanocomposite Films with Antimicrobial Activity Promoted by the Study of Mechanical, Thermal, and Surface Properties

et al. 2021

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Infection with pathogenic microorganisms is of great concern in many areas, especially in healthcare, but also in food packaging and storage, or in water purification systems. Antimicrobial polymer nanocomposites have gained great popularity in these areas. Therefore, this study focused on new approaches to develop thin antimicrobial films based on biodegradable polycaprolactone (PCL) with clay mineral natural vermiculite as a carrier for antimicrobial compounds, where the active organic antimicrobial component is antifungal ciclopirox olamine (CPX). For possible synergistic effects, a sample in combination with the inorganic antimicrobial active ingredient zinc oxide was also prepared. The structures of all the prepared samples were studied by X-ray diffraction, FTIR analysis and, predominantly, by SEM. The very different structure properties of the prepared nanofillers had a fundamental influence on the final structural arrangement of thin PCL nanocomposite films as well as on their mechanical, thermal, and surface properties. As sample PCL/ZnOVER_CPX possessed the best results for antimicrobial activity against examined microbial strains, the synergic effect of CPX and ZnO combination on antimicrobial activity was proved, but on the other hand, its mechanical resistance was the lowest.

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Enhanced antimicrobial performance of cloisite 30B/poly (ε-caprolactone) over cloisite 30B/poly ( l -lactic acid) as evidenced by structural features

Cited by 29 publications

References 33 publications

Research of Binary and Ternary Composites Based on Selected Aliphatic or Aliphatic–Aromatic Polymers, 5CB or SWCN toward Biodegradable Electrodes

Research of Binary and Ternary Composites Based on Selected Aliphatic or Aliphatic–Aromatic Polymers, 5CB or SWCN toward Biodegradable Electrodes

Physical and biological properties of electrospun poly(d,l‐lactide)/nanoclay and poly(d,l‐lactide)/nanosilica nanofibrous scaffold for bone tissue engineering

Development of Novel Thin Polycaprolactone (PCL)/Clay Nanocomposite Films with Antimicrobial Activity Promoted by the Study of Mechanical, Thermal, and Surface Properties

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