Enhanced antitumor activity of combined lipid bubble ultrasound and anticancer drugs in gynecological cervical cancers

Yamaguchi, Kohei; Matsumoto, Yōko; Suzuki, Ryo; Nishida, Hidetoshi; Omata, Daiki; Inaba, Hirofumi; Kukita, Asako; Sone, Kenbun; Oda, Katsutoshi; Osuga, Yutaka; Maruyama, Kazuo; Fujii, Tomoyuki

doi:10.1111/cas.14907

Cited by 12 publications

(6 citation statements)

References 55 publications

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“…This delivery system could be applied to nanomedicine such as DOXIL. Our collaborators reported anti-tumor effects in various types of tumors in mice 27,60) (Fig. 3C) or dog.…”

Section: Blood-tumor Barrier Openingmentioning

confidence: 88%

“…3B) in mouse xenograft model with lipid-stabilized microbubbles and diagnostic ultrasound scanner. 27) This bubble and ultrasound-mediated drug delivery system (BUS-DDS) significantly enhanced anti-tumor effects without any adverse events. Furthermore, Hirabayashi et al developed anti-epidermal growth factor receptor (EGFR) antibody-conjugated microbubbles (EGFR-MB).…”

Section: Blood-tumor Barrier Openingmentioning

confidence: 97%

“…[19][20][21][22][23] An enhancement of vascular permeability can improve delivery efficiency of low molecular weight compounds, genes, and proteins into the cells and tissues. [24][25][26] Our groups have also reported that the combination of ultrasound and microbubbles would be helpful in drug delivery and improvement of therapeutic effects. [27][28][29][30][31] Stability of microbubbles is one of the important properties to accomplish increased vascular permeability followed by drug delivery because microbubbles have to circulate in blood flow in targeted tissue after systematic administration.…”

Section: Microbubbles and Ultrasoundmentioning

confidence: 99%

“…[24][25][26] Our groups have also reported that the combination of ultrasound and microbubbles would be helpful in drug delivery and improvement of therapeutic effects. [27][28][29][30][31] Stability of microbubbles is one of the important properties to accomplish increased vascular permeability followed by drug delivery because microbubbles have to circulate in blood flow in targeted tissue after systematic administration. An inner gas of microbubbles passes a shell and gradually dissolves in the water outside of the microbubble.…”

Section: Microbubbles and Ultrasoundmentioning

confidence: 99%

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Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery

Omata

Munakata

Maruyama

et al. 2021

Biological & Pharmaceutical Bulletin

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Ultrasound and microbubbles, an ultrasound contrast agent, have recently increased attention to developing novel drug delivery systems. Ultrasound exposure can induce mechanical effects derived from microbubbles behaviors such as an expansion, contraction, and collapse depending on ultrasound conditions. These mechanical effects induce several biological effects, including enhancement of vascular permeability.For drug delivery, one promising approach is enhancing vascular permeability using ultrasound and microbubbles, resulting in improved drug transport to targeted tissues. This approach is applied to several tissues and drugs to cure diseases. This review describes the enhancement of vascular permeability by ultrasound and microbubbles and its therapeutic application, including our recent study. We also discuss the current situation of the field and its potential future perspectives.

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“…This delivery system could be applied to nanomedicine such as DOXIL. Our collaborators reported anti-tumor effects in various types of tumors in mice 27,60) (Fig. 3C) or dog.…”

Section: Blood-tumor Barrier Openingmentioning

confidence: 88%

Section: Blood-tumor Barrier Openingmentioning

confidence: 97%

Section: Microbubbles and Ultrasoundmentioning

confidence: 99%

Section: Microbubbles and Ultrasoundmentioning

confidence: 99%

See 2 more Smart Citations

Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery

Omata

Munakata

Maruyama

et al. 2021

Biological & Pharmaceutical Bulletin

Self Cite

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“…Colon cancer was also treated using UTMD technology with anti-PD-1, and the number and effector function of CD8 + T cells were systemically increased, thereby augmenting anti-PD-1 efficacy [ 118 ]. For gynaecologic tumours, UTMD combined with bevacizumab or plasmid pCMV-IL-12 or anti-PD-L1 antibody enhanced efficacy in cervical, endometrial, and ovarian cancers by increasing the migration and infiltration of CD8 + T cells [ 52 , 119 , 120 ]. In addition, UTMD has also been studied for the therapy of malignant melanoma.…”

Section: Enhanced Antitumor Efficacy In Different Cancer Species With...mentioning

confidence: 99%

Ultrasound-targeted microbubble destruction remodels tumour microenvironment to improve immunotherapeutic effect

et al. 2022

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Cancer immunotherapy (CIT) has gained increasing attention and made promising progress in recent years, especially immune checkpoint inhibitors such as antibodies blocking programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4). However, its therapeutic efficacy is only 10–30% in solid tumours and treatment sensitivity needs to be improved. The complex tissue environment in which cancers originate is known as the tumour microenvironment (TME) and the complicated and dynamic TME is correlated with the efficacy of immunotherapy. Ultrasound-targeted microbubble destruction (UTMD) is an emerging technology that integrates diagnosis and therapy, which has garnered much traction due to non-invasive, targeted drug delivery and gene transfection characteristics. UTMD has also been studied to remodel TME and improve the efficacy of CIT. In this review, we analyse the effects of UTMD on various components of TME, including CD8+ T cells, tumour-infiltrating myeloid cells, regulatory T cells, natural killer cells and tumour vasculature. Moreover, UTMD enhances the permeability of the blood-brain barrier to facilitate drug delivery, thus improving CIT efficacy in vivo animal experiments. Based on this, we highlight the potential of immunotherapy against various cancer species and the clinical application prospects of UTMD.

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Harnessing stimuli‐responsive biomaterials for advanced biomedical applications

Liao,

Liu,

Yao

et al. 2024

Exploration

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Cell behavior is intricately intertwined with the in vivo microenvironment and endogenous pathways. The ability to guide cellular behavior toward specific goals can be achieved by external stimuli, notably electricity, light, ultrasound, and magnetism, simultaneously harnessed through biomaterial‐mediated responses. These external triggers become focal points within the body due to interactions with biomaterials, facilitating a range of cellular pathways: electrical signal transmission, biochemical cues, drug release, cell loading, and modulation of mechanical stress. Stimulus‐responsive biomaterials hold immense potential in biomedical research, establishing themselves as a pivotal focal point in interdisciplinary pursuits. This comprehensive review systematically elucidates prevalent physical stimuli and their corresponding biomaterial response mechanisms. Moreover, it delves deeply into the application of biomaterials within the domain of biomedicine. A balanced assessment of distinct physical stimulation techniques is provided, along with a discussion of their merits and limitations. The review aims to shed light on the future trajectory of physical stimulus‐responsive biomaterials in disease treatment and outline their application prospects and potential for future development. This review is poised to spark novel concepts for advancing intelligent, stimulus‐responsive biomaterials.

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Enhanced antitumor activity of combined lipid bubble ultrasound and anticancer drugs in gynecological cervical cancers

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 12 publications

References 55 publications

Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery

Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery

Ultrasound-targeted microbubble destruction remodels tumour microenvironment to improve immunotherapeutic effect

Harnessing stimuli‐responsive biomaterials for advanced biomedical applications

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