Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery

Abstract

Ultrasound and microbubbles, an ultrasound contrast agent, have recently increased attention to developing novel drug delivery systems. Ultrasound exposure can induce mechanical effects derived from microbubbles behaviors such as an expansion, contraction, and collapse depending on ultrasound conditions. These mechanical effects induce several biological effects, including enhancement of vascular permeability.For drug delivery, one promising approach is enhancing vascular permeability using ultrasound and microbubbles, resulting in improved drug transport to targeted tissues. This approach is applied to several tissues and drugs to cure diseases. This review describes the enhancement of vascular permeability by ultrasound and microbubbles and its therapeutic application, including our recent study. We also discuss the current situation of the field and its potential future perspectives.

Transdermal drug delivery via microneedles for musculoskeletal systems

“…Moreover, it relies on professional personnel and expensive and sophisticated equipment, which is unfavorable for the long-term management of chronic diseases such as arthritis and osteoporosis. 23,24 The characteristics of other types of TDD are listed in Fortunately, MNs are expected to overcome these limitations. Differently, MNs can directly reach the dermis, where there is abundant blood flow, and can better deliver various kinds of drugs from micromolecules to macromolecules and hydrophilic drugs to hydrophobic ones.…”

“…Moreover, it relies on professional personnel and expensive and sophisticated equipment, which is unfavorable for the long-term management of chronic diseases such as arthritis and osteoporosis. 23,24 The characteristics of other types of TDD are listed in Table 1, omitting the examples here.…”

Fabrication and Evaluation of Ultrasound-Responsive Emulsion Loading Paclitaxel for Targeted Chemotherapy

“…Ultrasound-assisted drug delivery is typically used with microbubbles, which consist of ultrasoundresponsive agents (e.g., per uorocarbons and sulfur hexa uoride) and various shells (e.g., lipid, protein, or polymer) to stabilize particles [17][18][19]. The physical energy of ultrasound induces cavitation of microbubbles which include the expansion, contraction, and collapse of microbubbles under the ultrasound eld [20,21]. These phenomena could temporarily disrupt biological barriers and improve drug permeability [22,23].…”

Fabrication and Evaluation of Ultrasound-Responsive Emulsion Loading Paclitaxel for Targeted Chemotherapy

“…21−24 The physical energy of ultrasound induces cavitation of microbubbles which include the expansion, contraction, and collapse of microbubbles under the ultrasound field. 25,26 These phenomena could temporarily disrupt biological barriers and improve drug permeability. 27,28 Several strategies for ultrasound-assisted drug delivery have been proposed.…”

“…, perfluorocarbons and sulfur hexafluoride) and various shells ( e.g. , lipid, protein, or polymer) to stabilize particles. − The physical energy of ultrasound induces cavitation of microbubbles which include the expansion, contraction, and collapse of microbubbles under the ultrasound field. , These phenomena could temporarily disrupt biological barriers and improve drug permeability. , …”