Enhanced antitumor efficacy of folate targeted nanoparticles co-loaded with docetaxel and curcumin

Hu, Liandong; Pang, Saixi; Hu, Qiaofeng; Gu, Deliang; Kong, Dongqian; Xiong, Xiaoxing; Su, Jianying

doi:10.1016/j.biopha.2015.08.036

Cited by 17 publications

(4 citation statements)

References 23 publications

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“…The previous studies confirmed that folate receptors were overexpressed on the membrane of A549 cells (Muthukumar et al., 2014; Piras et al., 2014; Hu et al., 2015; Kato et al., 2017; Singh et al., 2017; Tanino et al., 2018). In the current study, the folate competitive inhibition was determined by MTT assay and images of confocal laser scanning microscopy (CLSM).…”

Section: Methodssupporting

confidence: 56%

Codelivery of DOX and siRNA by folate-biotin-quaternized starch nanoparticles for promoting synergistic suppression of human lung cancer cells

et al. 2019

Drug Delivery

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Section: Methodssupporting

confidence: 56%

Codelivery of DOX and siRNA by folate-biotin-quaternized starch nanoparticles for promoting synergistic suppression of human lung cancer cells

et al. 2019

Drug Delivery

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“…Additionally, nanocarriers can be modified by surface modification, and target molecules can be combined with receptors with high expression on the surface of tumor cells to achieve the purpose of active targeting delivery of drugs. Common targeted modification molecules include folate (FT) (Hu et al., 2015 ), hyaluronic acid (HA) (Zhang et al., 2019a ), lactoferrin (Lf) (Fang et al., 2014 ), polypeptide (Yan et al., 2017 ; Zan et al., 2019 ; Deng et al., 2020 ), wheat germ lectin (Wang et al., 2019c ), fucoidan (Chu et al., 2019 ), folic acid (FA) (Rawal et al., 2020a ), prostate-specific membrane antigen targeted ligand (Sun et al., 2021a ), rituximab (Varshosaz et al., 2021 ), etc.…”

Section: Advantages Of Ndcds Of Natural Drug Active Ingredients and C...mentioning

confidence: 99%

Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Shao

et al. 2022

Drug Delivery

124

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Chemotherapy drugs have been used for a long time in the treatment of cancer, but serious side effects are caused by the inability of the drug to be solely delivered to the tumor when treating cancer with chemotherapy. Natural products have attracted more and more attention due to the antitumor effect in multiple ways, abundant resources and less side effects. Therefore, the combination of natural active ingredients and chemotherapy drugs may be an effective antitumor strategy, which can inhibit the growth of tumor and multidrug resistance, reduce side effects of chemotherapy drugs. Nano-drug co-delivery system (NDCDS) can play an important role in the combination of natural active ingredients and chemotherapy drugs. This review provides a comprehensive summary of the research status and application prospect of nano-delivery strategies for the combination of natural active ingredients and chemotherapy drugs, aiming to provide a basis for the development of anti-tumor drugs.

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“…In a previous study, it was demonstrated that folate receptors were overexpressed on the membranes of A549 cells [9][10][11][12][13][14]. In the current study, the competitive inhibition of folate on the anticancer activity of DOX/FPCMC NPs was investigated using MTT assay.…”

Section: Free Folate Competitionmentioning

confidence: 89%

Hydroxychloroquine enhances anticancer effect of DOX/folate-phytosterol-carboxymethyl cellulose nanoparticles in A549 lung cancer cells

Elshazly¹,

Zhang²,

Yu³

et al. 2020

Trop. J. Pharm Res

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Purpose: To study the in vitro anticancer effect of doxorubicin-loaded folate-phytosterol-carboxymethyl cellulose nanoparticles (DOX/FPCMC NPs), alone and in combination with the antimalarial drug hydroxychloroquine (HCQ) on human lung cancer cells (A549 cells). Methods: Human lung adenocarcinoma A549 cell line was treated with blank FPCMC NPs, HCQ, free DOX, DOX/FPCMC NPs, free DOX + HCQ or DOX/FPCMC NPs + HCQ. The concentrations of HCQ, DOX and FPCMC NPs varied within the ranges of 20-120 μmol/L, 2-12 mg/L and 50-500 mg/L, respectively. Cell viability and free folate competitive inhibition were determined using MTT assay. Cell proliferation and migration were investigated with wound healing assay, while confocal laser scanning microscopy (CLSM) was used to determine cellular uptake of drugs. Results: In all formulations, the DOX/FPCMC NPs + HCQ produced the highest cytotoxicity in A549 cells due to high cytotoxicity arising from folate-receptor-mediated endocytosis and HCQ-induced inhibition of autophagy. Free folate competitively inhibited the cytotoxicity of DOX/FPCMC NPs on A549 cells. Wound healing assay showed that A549 cells treated with DOX/FPCMC NPs + HCQ had the lowest cell levels of proliferation and migration capacity. The cellular uptake of DOX/FPCMC NPs by A549 cells was higher than that of free DOX. Conclusion: The combination of DOX/FPCMC NPs and HCQ produced the best antitumor effect and had a promising potential for reversal of MDR Keywords: Folate-phytosterol-carboxymethyl cellulose, Doxorubicin, Hydroxychloroquine, Anticancer, Lung cancer

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Enhanced antitumor efficacy of folate targeted nanoparticles co-loaded with docetaxel and curcumin

Cited by 17 publications

References 23 publications

Codelivery of DOX and siRNA by folate-biotin-quaternized starch nanoparticles for promoting synergistic suppression of human lung cancer cells

Codelivery of DOX and siRNA by folate-biotin-quaternized starch nanoparticles for promoting synergistic suppression of human lung cancer cells

Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Hydroxychloroquine enhances anticancer effect of DOX/folate-phytosterol-carboxymethyl cellulose nanoparticles in A549 lung cancer cells

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