Enhanced Binding Efficiency of Microcantilever Biosensor for the Detection of Yersinia

Liu, Xiaochen; Wang, Lihao; Zhao, Junyuan; Zhu, Yong; Yang, Ji; Yang, Fuhua

doi:10.3390/s19153326

Cited by 16 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, improvements to static MCs have involved the integration of microfluidics with MC arrays to improve the functionality of the device [ 38 , 39 ]. One advantage of this approach is that it may be used with re-usable MC surfaces, creating a re-usable device that can be flushed to regenerate the surface after use [ 40 , 41 , 42 ].…”

Section: Mechanical Biosensorsmentioning

confidence: 99%

See 1 more Smart Citation

Biosensors Based on Mechanical and Electrical Detection Techniques

Chalklen

Jing

Kar‐Narayan

2020

Sensors

View full text Add to dashboard Cite

Biosensors are powerful analytical tools for biology and biomedicine, with applications ranging from drug discovery to medical diagnostics, food safety, and agricultural and environmental monitoring. Typically, biological recognition receptors, such as enzymes, antibodies, and nucleic acids, are immobilized on a surface, and used to interact with one or more specific analytes to produce a physical or chemical change, which can be captured and converted to an optical or electrical signal by a transducer. However, many existing biosensing methods rely on chemical, electrochemical and optical methods of identification and detection of specific targets, and are often: complex, expensive, time consuming, suffer from a lack of portability, or may require centralised testing by qualified personnel. Given the general dependence of most optical and electrochemical techniques on labelling molecules, this review will instead focus on mechanical and electrical detection techniques that can provide information on a broad range of species without the requirement of labelling. These techniques are often able to provide data in real time, with good temporal sensitivity. This review will cover the advances in the development of mechanical and electrical biosensors, highlighting the challenges and opportunities therein.

show abstract

Section: Mechanical Biosensorsmentioning

confidence: 99%

“…Another benefit to the combination of MCs and microfluidics is the capacity to use an array of multiple cantilevers in the same fluid. Either to measure the concentrations of multiple difference analytes or to improve the reliability of measurement with a single analyte [ 35 , 38 , 43 , 44 ].…”

Section: Mechanical Biosensorsmentioning

confidence: 99%

Biosensors Based on Mechanical and Electrical Detection Techniques

Chalklen

Jing

Kar‐Narayan

2020

Sensors

View full text Add to dashboard Cite

show abstract

“…Improvement in the binding efficiency of microcantilever array biosensor has been demonstrated by Liu et al [ 270 ] using the Yersinia detection method. They introduced an antibody to increase the capture efficiency by enhancing the binding sites and reaction efficiency.…”

Section: Microcantilever Sensors In Afm Applicationsmentioning

confidence: 99%

Review: Cantilever-Based Sensors for High Speed Atomic Force Microscopy

Alunda¹,

Lee

2020

Sensors

View full text Add to dashboard Cite

This review critically summarizes the recent advances of the microcantilever-based force sensors for atomic force microscope (AFM) applications. They are one the most common mechanical spring–mass systems and are extremely sensitive to changes in the resonant frequency, thus finding numerous applications especially for molecular sensing. Specifically, we comment on the latest progress in research on the deflection detection systems, fabrication, coating and functionalization of the microcantilevers and their application as bio- and chemical sensors. A trend on the recent breakthroughs on the study of biological samples using high-speed atomic force microscope is also reported in this review.

show abstract

“…Finally, Liu et al investigated the efficiency of a microcantilever biosensor for the detection of Yersinia pestis using a microfluidic platform. In their study, the surface of the microcantilevers was functionalized for the subsequent attachment of two types of Yersinia -specific antibodies [ 106 ].…”

Section: Diagnostic Applicationsmentioning

confidence: 99%

Biosensors-on-Chip: An Up-to-Date Review

et al. 2020

View full text Add to dashboard Cite

Generally, biosensors are designed to translate physical, chemical, or biological events into measurable signals, thus offering qualitative and/or quantitative information regarding the target analytes. While the biosensor field has received considerable scientific interest, integrating this technology with microfluidics could further bring significant improvements in terms of sensitivity and specificity, resolution, automation, throughput, reproducibility, reliability, and accuracy. In this manner, biosensors-on-chip (BoC) could represent the bridging gap between diagnostics in central laboratories and diagnostics at the patient bedside, bringing substantial advancements in point-of-care (PoC) diagnostic applications. In this context, the aim of this manuscript is to provide an up-to-date overview of BoC system development and their most recent application towards the diagnosis of cancer, infectious diseases, and neurodegenerative disorders.

show abstract

Enhanced Binding Efficiency of Microcantilever Biosensor for the Detection of Yersinia

Cited by 16 publications

References 20 publications

Biosensors Based on Mechanical and Electrical Detection Techniques

Biosensors Based on Mechanical and Electrical Detection Techniques

Review: Cantilever-Based Sensors for High Speed Atomic Force Microscopy

Biosensors-on-Chip: An Up-to-Date Review

Contact Info

Product

Resources

About