Enhanced biocompatibility and wound healing properties of biodegradable polymer-modified allyl 2-cyanoacrylate tissue adhesive

Lee, Young Ju; Son, Ho Sung; Jung, Gyeong Bok; Kim, Ji Hye; Choi, Samjin; Lee, Gi Ja; Park, Hun Kuk

doi:10.1016/j.msec.2015.02.042

Cited by 28 publications

(14 citation statements)

References 39 publications

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“…Cyanoacrylates can also be used in combination with other materials to improve their performance in particular interventions. For example, Lee et al prepared a hybrid adhesive composed of pre-polymerized allyl 2-cyanoacrylate (PACA) mixed with poly L-lactic acid (PLLA) [59] to enhance the biocompatibility and mechanical properties of cyanoacrylates. Bona et al reported using composite materials based on cyanoacrylates to enhance support and bonding strength in the context of strabismus surgery [60].…”

Section: Cyanoacrylate-based Ocular Adhesivesmentioning

confidence: 99%

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

et al. 2019

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Closure of ocular wounds after an accident or surgery is typically performed by suturing, which is associated with numerous potential complications, including suture breakage, inflammation, secondary neovascularization, erosion to the surface and secondary infection, and astigmatism; for example, more than half of post-corneal transplant infections are due to suture related complications. Tissue adhesives provide promising substitutes for sutures in ophthalmic surgery. Ocular adhesives are not only intended to address the shortcomings of sutures, but also designed to be easy to use, and can potentially minimize post-operative complications. Herein, recent progress in the design, synthesis, and application of ocular adhesives, along with their advantages, limitations, and potential are discussed. This review covers two main classes of ocular adhesives: (1) synthetic adhesives based on cyanoacrylates, polyethylene glycol (PEG), and other synthetic polymers, and (2) adhesives based on naturally derived polymers, such as proteins and polysaccharides. In addition, different technologies to cover and protect ocular wounds such as contact bandage lenses, contact lenses coupled with novel technologies, and decellularized corneas are discussed. Continued advances in this area can help improve both patient satisfaction and clinical outcomes.

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Section: Cyanoacrylate-based Ocular Adhesivesmentioning

confidence: 99%

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

et al. 2019

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“…Several biomaterials have been developed and are being investigated for clinical application as BRS: these include polymers such as poly-L-lactic acid (PLLA), poly(desaminotyrosiltyrosine ethyl ester) carbonate, polycaprolactone, salicylic acid and metals such as magnesium and iron 2 . Amongst these, PLLA remains the most commonly used polymer because of good biocompatibility, biodegradability, a high mechanical strength and good shaping and moulding properties 3 .…”

Section: Introductionmentioning

confidence: 99%

First-in-human evaluation of a novel poly-L-lactide based sirolimus-eluting bioresorbable vascular scaffold for the treatment of de novo native coronary artery lesions: MeRes-1 trial

Seth

Onuma²,

Costa³

et al. 2017

EuroIntervention

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“…[4] An ideal CA should be simply applied, biocompatible, biodegradable with minimal tissue toxicity, without foreign body/inflammatory response and be cost-effective. [3,8] Numerous previous studies have revealed simple applicability, biocompatibility, minimal toxicity and to an extent, cost-effectiveness of CAs used in surgical treatment of CVI. [1,2] In this study, the main aims were to document toxicity quantitatively and also apoptotic potential of CAs rather than clinical characteristics.…”

Section: Discussionmentioning

confidence: 99%

The cytotoxic properties and apoptotic potential of N-butyl and 2-octyl cyanoacrylates used in surgical treatment of chronic venous insufficiency

Durukan

Akbay

Ünlü

et al. 2019

Turk Gogus Kalp Dama

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Bu çalışmada kronik venöz yetmezliğin cerrahi tedavisinde kullanılan N-butil siyanoakrilat ve 2-oktil siyanoakrilatın sitotoksik etkileri ve apoptotik potansiyelleri araştırıldı. Ça lış ma pla nı: N-butil siyanoakrilat ve 2-oktil siyanoakrilat insan umbilikal endotelyal hücre hattı kullanılarak hücre kültüründe kültüre edildi. Sitotoksisite ve viabilite 24. ve 72. saatlerde sırasıyla laktat dehidrogenaz ve 3-(4,5-dimetiltiyazol-2-il)-2,5-difeniltetrazolium bromid çalışmaları ile değerlendirildi. Apoptotik potansiyel kaspaz-3 aktivitesi ile 24. ve 72. saatlerde belgelendi. Bul gu lar: Yirmi dört ve 72. saatlerdeki ortalama sitotoksisite şöyle idi: dot/line alanı olan N-butil siyanoakrilat: %37.0±3.9/%29.3±2.7 ve %46.4±1.6/%45.1±7.1, dot/line alanı olan 2-oktil siyanoakrilat: %39.0±7.0/%37.3±4.6 ve %47.0±2.3/%40.7±7.5. Her grupta sitotoksisite zamanla arttı (p<0.05). Yirmi dört ve 72. saatlerdeki ortalama viabilite şöyle idi: dot/line alanı olan N-butil siyanoakrilat: %53.4±7.7/%72.0±5.7% ve %35.7±1.9/%37.8±3.7, dot/line alanı olan 2-oktil siyanoakrilat: %54.3±4.4/%73.5±19.9% ve %33.6±2.8/%30.7±4.5. Her grupta viabilite zamanla azaldı (p<0.05). Yirmi dört ve 72. saatlerdeki ortalama relatif kaspaz-3 aktivitesi şöyle idi: kontrol grubu: 0.084±0.006 ve 0.065±0.002, dot/line alanı olan N-butil siyanoakrilat: 0.940±0.037/0.924±0.053 ve 0.999±0.072/1.056±0.015, dot/line alanı olan 2-oktil siyanoakrilat: 0.900±0.044/0.928±0.018 ve 0.989±0.084/0.999±0.072. Her zaman aralığında, her grupta ortalama kaspaz-3 aktivitesi kontrol grubundan daha yüksek idi (p<0.05) ve aktivite N-butil siyanoakrilat ve 2-oktil siyanoakrilat gruplarında zamanla arttı (p<0.05). So nuç: Bulgularımız, N-butil siyanoakrilat ve 2-oktil siyanoakrilatın hücre kültürü ortamında sitotoksisiteye neden olduğuna işaret etmektedir. Hücre kültürü ortamında apoptozu indüklediklerini de söyleyebilir.

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Enhanced biocompatibility and wound healing properties of biodegradable polymer-modified allyl 2-cyanoacrylate tissue adhesive

Cited by 28 publications

References 39 publications

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

First-in-human evaluation of a novel poly-L-lactide based sirolimus-eluting bioresorbable vascular scaffold for the treatment of de novo native coronary artery lesions: MeRes-1 trial

The cytotoxic properties and apoptotic potential of N-butyl and 2-octyl cyanoacrylates used in surgical treatment of chronic venous insufficiency

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