Enhanced bone repair by silver-doped magnesium calcium phosphate bone cements

Крохичева, П. А.; Goldberg, M. A.; Фомин, А. С.; Хайрутдинова, Д. Р.; Антонова, О. С.; Баикин, А. С.; Коновалов, А. А.; Leonov, Aleksander V.; Mikheev, Ivan V.; Merzlyak, Ekaterina M.; Кирсанова, В. А.; Свиридова, И. К.; Сергеева, Н. С.; Баринов, С. М.; Komlev, V. S.

doi:10.1016/j.ceramint.2023.03.052

Cited by 9 publications

(6 citation statements)

References 86 publications

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“…As already mentioned in the introduction, the present authors have evaluated MCPCs doped with silver ions [ 19 ] but, given the high cost of silver as a metal, the present authors decided to try an alternative: a study on doping with zinc. Zinc is known to have an antibacterial effect.…”

Section: Discussionmentioning

confidence: 99%

“…Futher, MgO recrystallization into struvite occurs (Krokhicheva et al, 2023), and dissolved ions interact with the original phases of the cement powder. Due to the presence of Ca 2+ at 60 mol.%, we assume the emergence of amorphous crystalline hydrate phase CaHPO 4 •2H 2 O (brushite) via the following reaction:…”

Section: Characterization Of the Cement Materialsmentioning

confidence: 99%

“…The most common ion introduced into cement materials to achieve antimicrobial activity is silver. It has been demonstrated that the presence of silver ions can eliminate chronic osteomyelitis [ 18 ], and the introduction of Ag + cations lead to greater mechanical strength and antibacterial effects against both gram-positive and gram-negative bacteria [ 19 ]. Nonetheless, it should be noted that silver is not an element that is present in the body in appreciable amounts and, therefore, there may be health risks associated with its toxicity [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…A newberyite-based MCPC described in our previous paper shows a neutral pH level (7–8), a setting time of 10–13 min, mechanical strength up to 22 ± 3 MPa, cytocompatibility, and acceptable matrix surface properties [ 13 ]. Improved mechanical properties, as well as cytocompatibility and antibacterial activity, have been achieved for newberyite struvite-based bone cements that are doped with silver ions [ 19 ]. On the other hand, regarding the controversial effects of silver, the development of Zn 2+ -doped MCPCs is expected to improve the antibacterial properties and osteogenic ability of MCPCs because a release of Zn 2+ may enhance osteogenic differentiation of certain cells for accelerated bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

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Zn-Doped Calcium Magnesium Phosphate Bone Cement Based on Struvite and Its Antibacterial Properties

et al. 2023

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The development of magnesium calcium phosphate bone cements (MCPCs) has garnered substantial attention. MCPCs are bioactive and biodegradable and have appropriate mechanical and antimicrobial properties for use in reconstructive surgery. In this study, the cement powders based on a (Ca + Mg)/P = 2 system doped with Zn2+ at 0.5 and 1.0 wt.% were obtained and investigated. After mixing with a cement liquid, the structural and phase composition, morphology, chemical structure, setting time, compressive strength, degradation behavior, solubility, antibacterial activities, and in vitro behavior of the cement materials were examined. A high compressive strength of 48 ± 5 MPa (mean ± SD) was achieved for the cement made from Zn2+ 1.0 wt.%-substituted powders. Zn2+ introduction led to antibacterial activity against Staphylococcus aureus and Escherichia coli strains, with an inhibition zone diameter of up to 8 mm. Biological assays confirmed that the developed cement is cytocompatible and promising as a potential bone substitute in reconstructive surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Characterization Of the Cement Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Zn-Doped Calcium Magnesium Phosphate Bone Cement Based on Struvite and Its Antibacterial Properties

et al. 2023

Self Cite

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show abstract

“…A newberyite-based MCPC described in our previous paper shows a neutral pH level (7)(8), a setting time of 10-13 min, mechanical strength up to 22 ± 3 MPa, cytocompatibility, and acceptable matrix surface properties [13]. Improved mechanical properties, as well as cytocompatibility and antibacterial activity, have been achieved for newberyite struvitebased bone cements that are doped with silver ions [19]. On the other hand, regarding the controversial effects of silver, the development of Zn 2+ -doped MCPCs is expected to improve the antibacterial properties and osteogenic ability of MCPCs because a release of Zn 2+ may enhance osteogenic differentiation of certain cells for accelerated bone regeneration.…”

Section: Introductionmentioning

confidence: 95%

Zn-Doped Calcium Magnesium Phosphate Bone Cements Based on Struvite and Their Antibacterial Properties

Крохичева¹,

Goldberg²,

Фомин³

et al. 2023

Preprint

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The development of magnesium calcium phosphate bone cements (MCPCs) have garnered big attention. MCPCs are bioactive and biodegradable and have appropriate mechanical and antimicrobial properties for use in reconstructive surgery. In this study, the cement powders based on a (Ca + Mg)/P = 2 system doped with Zn2+ at 0.5 and 1.0 wt.% were obtained and investigated. After the mixing with a cement liquid, structural and phase composition, morphology, chemical structure, setting time, compressive strength, degradation behavior, solubility, antibacterial activities, and in vitro behaviour of the cement materials were examined. A high compressive strength of 48 ± 5 MPa (mean ± SD) was achieved for the cement made from Zn2+ 1.0-wt.%-substituted powders. The Zn2+ introduction led to antibacterial activity against Staphylococcus aureus and Escherichia coli strains, with an inhibition zone diameter up to 8 mm. Biological assays confirmed that the developed cements are cytocompatible and promising as a potential bone substitute in reconstructive surgery.

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Cytotoxicity and antioxidant activity of iron oxide nanopowders synthesized by radiation-chemical method using different precursors

Sokovnin,

Ulitko,

Balezin

et al. 2024

Ceramics International

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Enhanced bone repair by silver-doped magnesium calcium phosphate bone cements

Cited by 9 publications

References 86 publications

Zn-Doped Calcium Magnesium Phosphate Bone Cement Based on Struvite and Its Antibacterial Properties

Zn-Doped Calcium Magnesium Phosphate Bone Cement Based on Struvite and Its Antibacterial Properties

Zn-Doped Calcium Magnesium Phosphate Bone Cements Based on Struvite and Their Antibacterial Properties

Cytotoxicity and antioxidant activity of iron oxide nanopowders synthesized by radiation-chemical method using different precursors

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