Enhanced burst strength of catechol groups-modified Alaska pollock-derived gelatin-based surgical adhesive

Nagasaka, Kazuhiro; Watanabe, Shiharu; Ito, Shima; Ichimaru, Hiroaki; Nishiguchi, Akihiro; Otsuka, Hidenori; Taguchi, Tetsushi

doi:10.1016/j.colsurfb.2022.112946

Cited by 2 publications

(1 citation statement)

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“…[ 33 ] The α CD/22C10‐ApGltn adhesive hydrogel degraded slow compared to Org‐ApGltn adhesive hydrogel because of its additional physical crosslinking due to the self‐assembly of decyl groups. Therefore, cell infiltration and enzymatic degradation by MMPs, [ 34 ] such as MMP‐2 and MMP‐9 [ 35,36 ] were delayed when α CD/22C10‐ApGltn adhesive hydrogel was implanted. On the other hand, the PEG adhesive hydrogel was mainly degraded by the hydrolysis of ester bonds in 4S‐PEG and showed a slower degradation rate than the Org‐ and α CD/22C10‐ApGltn adhesive hydrogels because there were no specific cleavage sites for the enzyme.…”

Section: Resultsmentioning

confidence: 99%

Improved Swelling Property of Tissue Adhesive Hydrogels Based on α‐Cyclodextrin/Decyl Group‐Modified Alaska Pollock Gelatin Inclusion Complexes

Komatsu

Watanabe

Ito

et al. 2023

Macromolecular Bioscience

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Adhesives/sealants are used after suturing to prevent leakage of cerebrospinal fluid from an anastomotic site. Commercial adhesives/sealants have been used to close the cerebral dura. However, swelling of the cured adhesives/sealants induces increased intracranial pressure and decreases the strength of the seal. In the present study, tissue adhesive hydrogels with improved swelling property using inclusion complex composed of 𝜶-cyclodextrin (𝜶CD) and decyl group (C10)-modified Alaska pollock-derived gelatin (C10-ApGltn) with a high degree of substitution (DS) (>20 mol%) are developed. Viscosity of C10-ApGltn with a high DS solution remarkably decreased by the addition of 𝜶CD. The resulting 𝜶CD/C10-ApGltn adhesive hydrogel composed of 𝜶CD/C10-ApGltn inclusion complexes and poly(ethylene glycol) (PEG)-based crosslinker showed improved swelling property after immersion in saline. Also, the resulting adhesive has a significantly higher burst strength than fibrin-based adhesives and is as strong as a PEG-based adhesive. Quantitative analysis of 𝜶CD revealed that the improved swelling property of the resulting adhesive hydrogels is induced by the release of 𝜶CD from cured adhesive, and the subsequent assembly of decyl groups in the saline. These results suggest that adhesives developed using the 𝜶CD/C10-ApGltn inclusion complex can be useful for closing the cerebral dura mater.

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Section: Resultsmentioning

confidence: 99%