Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate

Pujara, Naisarg; Jambhrunkar, Siddharth; Wong, Kuan Yau; McGuckin, Michael A.; Popat, Amirali

doi:10.1016/j.jcis.2016.11.015

Cited by 147 publications

(73 citation statements)

References 41 publications

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“…Innovative DDSs of resveratrol, such as polymeric nanoparticles, cyclodextrins, colloidal mesoporous silica nanoparticles and liposomes, have been fabricated to enhance aqueous solubility and bioavailability, improve physicochemical stability and achieve targeted or controlled drug release. [5][6][7] Recently, different classical and successful nanotherapeutics used to transport anticancer drugs into tumors have been fabricated and applied in order to improve the anticancer effect of chemotherapeutic drugs, the most prominent among which include polymeric nanocarriers such as liposomes, supramolecular derivatives and ultradeformable vesicles. [8][9][10] As one of the promising nanoparticular approaches, the mixed micelle carriers formed by triblock copolymers for delivery of anticancer drugs have been basically exploited in various clinical applications for the merits of smaller size, self-assembling ability, solubilization and protection against unstable drugs.…”

Section: Introductionmentioning

confidence: 99%

Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-α-tocopheryl polyethylene glycol 1000 succinate mixed micelles

Hao¹,

Tong²,

Jin³

et al. 2017

IJN

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A folic acid (FA)-functionalized drug vehicle platform based on Pluronic 127 (P127)/D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) mixed micelles was orchestrated for an effective delivery of the model drug resveratrol in order to address the problem of poor water solubility and rapid metabolism of resveratrol and improve its targeted accumulation at tumor site. The FA-decorated mixed micelles were prepared using thin-film hydration method and optimized by central composite design approach. The micelles were also characterized in terms of size and morphology, drug entrapment efficiency and in vitro release profile. In addition, the cytotoxicity and cell uptake of the micelles were evaluated in folate receptor-overexpressing MCF-7 cell line. In vivo pharmacokinetic and biodistribution studies were also performed. The average size of the micelles was ~20 nm with a spherical shape and high encapsulation efficiency (99.67%). The results of fluorescence microscopy confirmed the targeting capability of FA-conjugated micelles in MCF-7 cells. FA-modified micelles exhibited superior pharmacokinetics in comparison with that of solution. Further, the low accumulation of resveratrol-loaded FA micelles formulation in the heart and kidney avoided toxicity of these vital organs. It could be concluded that folate-modified P127/TPGS mixed micelles might serve as a potential delivery platform for resveratrol.

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Section: Introductionmentioning

confidence: 99%

Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-α-tocopheryl polyethylene glycol 1000 succinate mixed micelles

Hao¹,

Tong²,

Jin³

et al. 2017

IJN

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“…The crystalline structures of the NWs were inspected by XRD and the results are shown in Figure d. It evidently identifies the amorphous nature of SP, which shows a broad peak of 2θ in the range of 15°–25° . At the same time, the XRD pattern of TiO 2 NWs calcinated at 500 °C reveals five peaks at 25.3°, 37.9°, 48.1°, 53.9°, and 55.2°, which can be indexed to (101), (004), (200), (105), and (211) plans of anatase phase, respectively.…”

Section: Resultsmentioning

confidence: 93%

Core–Shell Hybrid Nanowires with Protein Enabling Fast Ion Conduction for High‐Performance Composite Polymer Electrolytes

Wang

Fan

et al. 2018

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Incorporating nanofillers is one of the promising approaches for simultaneously boosting the ionic conductivity and mechanical properties of solid polymer electrolytes (SPEs). However, effectively creating faster ion‐conduction pathways via nanofillers still remains a big challenge. Herein, core–shell protein–ceramic nanowires for more efficiently building fast ion‐conduction networks in SPEs are reported. The core–shell protein–ceramic nanowires are fabricated via in situ growth of protein coating on the electrospun TiO2 nanowires in a subtly controlled protein‐denaturation process. It is demonstrated that the core–shell protein@TiO2 nanowires effectively facilitate ion‐conduction. As a result, the ionic conductivity, mechanical properties, electrochemical stability, and even Li+ transference number of the SPEs with core–shell protein@TiO2 nanowires are significantly enhanced. The contributions from the 1D morphology of the protein@TiO2 nanowires, and more importantly, the favorable protein structure for further promoting ion‐conduction at the polymer–filler interfaces are analyzed. It is believed that the protein plays a pivotal role in dissociating lithium salts, which benefits from the strong interactions between protein and ions, making the protein serve as a unique “natural channel” for rapidly conducting Li+. This study initiates an effective method of promoting ionic conductivity and constructing faster ion‐conduction networks in SPEs via combining bio‐ and nanotechnology.

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“…In contrast, RSV‐SPI complex nanoparticles enhanced 2‐fold the solubility of RSV in relation with unencapsulated RSV . Similarly, MCM‐48 also enhanced, approximately 2 times, the RSV solubility when it was encapsulated …”

Section: Overcoming Limitationsmentioning

confidence: 97%

“…RSV was also encapsulated within soy protein isolate (SPI) nanoparticles using a simple rotary evaporation technique by Pujara and co‐workers . A SPI‐RSV complex formed the formulation, for which a RSV solution in ethanol (1 g/L) was dropped onto the SPI dispersion.…”

Section: Delivery Systemsmentioning

confidence: 99%

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Recent Strategies in Resveratrol Delivery Systems

2019

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Resveratrol, a natural polyphenolic stilbenoid widely found in grapes and wines, displays beneficial properties such as cardio‐protective, antioxidant and anti‐inflammatory activities. Trans‐resveratrol (RSV) is the most bioactive and more abundant stereoisomer found in nature. Despite the positive properties of RSV, there are various factors that limit its effectiveness, including low aqueous solubility, low oral bioavailability and chemical instability. During the last years, an increasing number of strategies such as nano and micro encapsulation have been developed in order to overcome these limitations and enhance the use of RSV in nutritional and pharmaceutical applications. This Review summarizes the advances and main properties of several RSV carriers and delivery systems reported during the last 5 years.

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Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate

Cited by 147 publications

References 41 publications

Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-α-tocopheryl polyethylene glycol 1000 succinate mixed micelles

Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-α-tocopheryl polyethylene glycol 1000 succinate mixed micelles

Core–Shell Hybrid Nanowires with Protein Enabling Fast Ion Conduction for High‐Performance Composite Polymer Electrolytes

Recent Strategies in Resveratrol Delivery Systems

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Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate

Cited by 147 publications

References 41 publications

Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-&alpha;-tocopheryl polyethylene glycol 1000 succinate mixed micelles

Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-&alpha;-tocopheryl polyethylene glycol 1000 succinate mixed micelles

Core–Shell Hybrid Nanowires with Protein Enabling Fast Ion Conduction for High‐Performance Composite Polymer Electrolytes

Recent Strategies in Resveratrol Delivery Systems

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Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-α-tocopheryl polyethylene glycol 1000 succinate mixed micelles

Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-α-tocopheryl polyethylene glycol 1000 succinate mixed micelles