Recent Strategies in Resveratrol Delivery Systems

Machado, Noelia D.; Fernández, Mariana A.; Díaz, David Díaz

doi:10.1002/cplu.201900267

Cited by 41 publications

(28 citation statements)

References 72 publications

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“…Nevertheless, the exact mechanism of the antibacterial and antibiofilm activity of RSV remains uncertain. However, the clinical applications of these results remain controversial, due to RSV poor pharmacokinetics, low water solubility, and in vivo rapid metabolism [ 18 , 19 ]. The local administration into the peri-implant region could address this issue as it helps avoiding systemic degradation of RSV, increasing its therapeutic concentration.…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections

Bonadies

Cristo²,

Valentino³

et al. 2020

Nanomaterials

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To date, the implant-associated infections represent a worldwide challenge for the recently reported bacterial drug resistance that can lead to the inefficacy or low efficacy of conventional antibiotic therapies. Plant polyphenolic compounds, including resveratrol (RSV), are increasingly gaining consensus as valid and effective alternatives to antibiotics limiting antibiotic resistance. In this study, electrospun polylactic acid (PLA) membranes loaded with different concentrations of RSV are synthesized and characterized in their chemical, morphological, and release features. The obtained data show that the RSV release rate from the PLA-membranes is remarkably higher in acidic conditions than at neutral pH. In addition, a change in pH from neutral to slightly acidic triggers a significant increase in the RSV release. This behavior indicates that the PLA-RSV membranes can act as drug reservoir when the environmental pH is neutral, starting to release the bioactive molecules when the pH decreases, as in presence of oral bacterial infection. Indeed, our results demonstrate that PLA-RSV2 displays a significant antibacterial and antibiofilm activity against two bacterial strains, Pseudomonas aeruginosa PAO1, and Streptococcus mutans, responsible for both acute and chronic infections in humans, thus representing a promising solution for the prevention of the implant-associated infections.

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Section: Introductionmentioning

confidence: 99%

pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections

Bonadies

Cristo²,

Valentino³

et al. 2020

Nanomaterials

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“…The reports also demonstrated that the most efficient strategy in promoting the bioavailability and protective effects of Res is using nanoparticles [ 61 ]. The encapsulation of Res by nanoparticles protects against degradation and improves its intestinal absorption and blood circulation time [ 62 , 63 , 64 , 65 , 66 ]. These benefits lead to the promoted bioavailability of Res and an improvement in its therapeutic effects [ 67 , 68 ].…”

Section: Resveratrolmentioning

confidence: 99%

Resveratrol Modulates Transforming Growth Factor-Beta (TGF-β) Signaling Pathway for Disease Therapy: A New Insight into Its Pharmacological Activities

et al. 2020

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Resveratrol (Res) is a well-known natural product that can exhibit important pharmacological activities such as antioxidant, anti-diabetes, anti-tumor, and anti-inflammatory. An evaluation of its therapeutic effects demonstrates that this naturally occurring bioactive compound can target different molecular pathways to exert its pharmacological actions. Transforming growth factor-beta (TGF-β) is an important molecular pathway that is capable of regulating different cellular mechanisms such as proliferation, migration, and angiogenesis. TGF-β has been reported to be involved in the development of disorders such as diabetes, cancer, inflammatory disorders, fibrosis, cardiovascular disorders, etc. In the present review, the relationship between Res and TGF-β has been investigated. It was noticed that Res can inhibit TGF-β to suppress the proliferation and migration of cancer cells. In addition, Res can improve fibrosis by reducing inflammation via promoting TGF-β down-regulation. Res has been reported to be also beneficial in the amelioration of diabetic complications via targeting the TGF-β signaling pathway. These topics are discussed in detail in this review to shed light on the protective effects of Res mediated via the modulation of TGF-β signaling.

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“…The pathological process of vascular remodeling during cardiovascular diseases includes changes in biological activities and parameters of the cell ,that is, proliferation, differentiation, vascular, homeostasis, and apoptosis. [ 134 ] Newly originated mechanical stresses further initiate shear stress and cyclic stretch, which are the key factors of vascular remodeling. The vascular cells and cytoskeletons are capable of sensing mechanical factors through proteins in the cell membrane and nuclear envelope.…”

Section: Mechanobiology Of Arteriosclerosis Strokes Heart Attacks mentioning

confidence: 99%

The convergence of nanotechnology‐stem cell, nanotopography‐mechanobiology, and biotic‐abiotic interfaces: Nanoscale tools for tackling the top killer, arteriosclerosis, strokes, and heart attacks

Kumar

Gulia

2020

Nano Select

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The nanotechnology‐stem cell has enabled the engineering of nanotopographical surfaces for mimicking the topological features of nano‐stem cell interfaces and stem cell niches. The nanotechnology‐stem cell, an abiotic–biotic model, the impact of the multi‐functional materials underlying support on nanomaterials interactions with stem cells plays a significant role in the development of the nanoscale tools for tracking the top killer, arteriosclerosis, strokes, and heart attacks. The biomimetic topographical surfaces, employed in cell mechanobiology (cell adhesions, migrations, and differentiation) and tissue engineering. The conformational features of the scaffold (ridges, grooves, whorls, pits, and pores, and symmetry) alter stem cell behavior and differentiation. Biomedical engineering is offering promises and explaining how the convergence of nanotechnology and stem cells has emerged as novel therapeutics. The analysis of mechanotransduction and tissue engineering is the key factor, which altogether influence the stem cell niche, can be considered for originating nanno‐stem cell interface, and a useful remedy for treating cardiovascular diseases. The Hippo pathway underlined the signaling cascade responsible for inhibiting cell proliferation. Notch signaling is a key pathway that regulates the modulation of cardiomyocyte survival, cardiac stem cell differentiation. The Wnt/β‐catenin signaling involved in chronic infusion of angiotensin II (Ang II), cardiomyocytes, and cardiac fibroblasts.

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Recent Strategies in Resveratrol Delivery Systems

Cited by 41 publications

References 72 publications

pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections

pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections

Resveratrol Modulates Transforming Growth Factor-Beta (TGF-β) Signaling Pathway for Disease Therapy: A New Insight into Its Pharmacological Activities

The convergence of nanotechnology‐stem cell, nanotopography‐mechanobiology, and biotic‐abiotic interfaces: Nanoscale tools for tackling the top killer, arteriosclerosis, strokes, and heart attacks

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