Enhanced concentrations of relevant markers of nitric oxide formation after exercise training in patients with metabolic syndrome

Gomes, Viviani; Casella-Filho, Antonio; Chagas, Antônio Carlos Palandri; Tanus‐Santos, José Eduardo

doi:10.1016/j.niox.2008.08.005

Cited by 65 publications

(51 citation statements)

References 43 publications

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“…However, these levels were significantly reduced after training, with at least some part being related to incensement in nitric oxide production. A similar reduction in the ADMA concentration after training in patients with diabetes mellitus has been reported (23).…”

supporting

confidence: 83%

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The Effect of Acute and Chronic Moderate and High Intensity Aerobic Exercise on Serum Nitric Oxide in Untrained Overweight Males

Nikbakht

Nasab

Shakerian

2017

Jentashapir J Helath Res

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supporting

confidence: 83%

“…(22)(23)(24). Gomes et al (2008) examined the relationship of nitric oxide in patients with metabolic syndrome. The intensity of training was 10% lower than aerobic threshold of the participants.…”

mentioning

confidence: 99%

The Effect of Acute and Chronic Moderate and High Intensity Aerobic Exercise on Serum Nitric Oxide in Untrained Overweight Males

Nikbakht

Nasab

Shakerian

2017

Jentashapir J Helath Res

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“…Regular physical exercise has been shown to reduce circulating levels of ADMA in patients with increased risk of coronary heart disease [19], in patients with metabolic syndrome [20] and type 1 diabetes mellitus [21]. To date, no study has examined the effects of repeated bouts of moderate-intensity exercise on ADMA concentrations in individuals with type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Rapid Communication – Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetes

Serre

Simmonds²,

Sabapathy³

et al. 2012

Endocrinol Metabol Syndrome

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Aims/hypothesis: Basal plasma concentration of asymmetric dimethylarginine (ADMA), an endogenous, competitive inhibitor of nitric oxide synthase, is elevated in patients with type 2 diabetes. ADMA may contribute to the endothelial dysfunction and associated vascular complications observed in individuals with type 2 diabetes. The present study investigated the effect of 12 weeks of supervised walking exercise on plasma ADMA concentration in women aged 65-74 years with type 2 diabetes. Materials and methods:Fourteen women (aged 69 ± 3 yrs) with uncomplicated type 2 diabetes, completed 12 weeks of supervised, moderate-intensity walking at an intensity equivalent to their individual gas-exchange threshold. Blood was sampled for ADMA concentration before and after a 6-week intervention-free control period, and again after 6 and 12 weeks of exercise training.Results: Plasma ADMA concentration was found to be significantly lower after 12-weeks of exercise training when compared with baseline (0 wk) measurements. These results were accompanied by significant increases in time to exhaustion, relative and absolute peak oxygen uptake, and oxygen uptake at gas-exchange threshold. Conclusion/interpretation:Regular, moderate-intensity exercise decreases circulating ADMA concentrations in older women with type 2 diabetes. These results suggest that ADMA may play a role in the training-induced reduction in cardiovascular disease risk seen with exercise training in individuals with type 2 Diabetes.

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“…Some investigators have documented a marked buffering capacity of NO continuously released by endothelium, reducing the LF oscillations of arterial pressure (32). Since endothelial dysfunction in MetS patients (10) worsened by the association of OSA (7) despite a reduction in LF oscillation of MSNA, the lack of buffering capacity of NO could be translated in a higher LF oscillation in SAP.…”

Section: Discussionmentioning

confidence: 99%

Time delay of baroreflex control and oscillatory pattern of sympathetic activity in patients with metabolic syndrome and obstructive sleep apnea

Toschi‐Dias

Trombetta

Silva

et al. 2013

American Journal of Physiology-Heart and Circulatory Physiology

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Toschi-Dias E, Trombetta IC, Dias da Silva VJ, Maki-Nunes C, Cepeda FX, Alves MJ, Drager LF, Lorenzi-Filho G, Negrao CE, Rondon MU. Time delay of baroreflex control and oscillatory pattern of sympathetic activity in patients with metabolic syndrome and obstructive sleep apnea. Am J Physiol Heart Circ Physiol 304: H1038-H1044, 2013. First published January 25, 2013; doi:10.1152/ajpheart.00848.2012.-The incidence and strength of muscle sympathetic nerve activity (MSNA) depend on the magnitude (gain) and latency (time delay) of the arterial baroreflex control (ABR). However, the impact of metabolic syndrome (MetS) and obstructive sleep apnea (OSA) on oscillatory pattern of MSNA and time delay of the ABR of sympathetic activity is unknown. We tested the hypothesis that MetS and OSA would impair the oscillatory pattern of MSNA and the time delay of the ABR of sympathetic activity. Forty-three patients with MetS were allocated into two groups according to the presence of OSA (MetS ϩ OSA, n ϭ 21; and MetS Ϫ OSA, n ϭ 22). Twelve aged-paired healthy controls (C) were also studied. OSA (apnea-hypopnea index Ͼ 15 events/h) was diagnosed by polysomnography. We recorded MSNA (microneurography), blood pressure (beat-to-beat basis), and heart rate (EKG). Oscillatory pattern of MSNA was evaluated by autoregressive spectral analysis and the ABR of MSNA (ABR MSNA, sensitivity and time delay) by bivariate autoregressive analysis. Patients with MetS ϩ OSA had decreased oscillatory pattern of MSNA compared with MetS Ϫ OSA (P Ͻ 0.01) and C (P Ͻ 0.001). The sensitivity of the ABR MSNA was lower and the time delay was greater in MetS ϩ OSA compared with MetS Ϫ OSA (P Ͻ 0.001 and P Ͻ 0.01, respectively) and C (P Ͻ 0.001 and P Ͻ 0.001, respectively). Patients with MetS Ϫ OSA showed decreased oscillatory pattern of MSNA compared with C (P Ͻ 0.01). The sensitivity of the ABR MSNA was lower in MetS Ϫ OSA than in C group (P Ͻ 0.001). In conclusion, MetS decreases the oscillatory pattern of MSNA and the magnitude of the ABR MSNA. OSA exacerbates these autonomic dysfunctions and further increases the time delay of the baroreflex response of MSNA. latency of baroreflex control; muscle sympathetic nerve activity variability; heart rate variability SYMPATHETIC NERVE ACTIVITY is increased in patients with metabolic syndrome (MetS) (11,22), which enhances the risk of cardiovascular disease and likely cardiac death (5,20,21). Obstructive sleep apnea (OSA), a frequent comorbidity in patients with MetS (8), is characterized by recurrent episodes of partial or complete upper airway obstruction during sleep, leading to intermittent hypoxemia and frequent arousals from sleep (40). Additionally, OSA exacerbates the muscle sympathetic nerve activity (MSNA) in patients with MetS (12, 37) and impairs arterial baroreflex control (ABR) of heart rate (HR) (12, 37). Grassi et al. (12) demonstrated that ABR of HR was further decreased in patients with MetS and OSA. We confirmed that OSA exacerbates the dysfunction of the ABR of HR in patients with MetS (37).The ...

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Enhanced concentrations of relevant markers of nitric oxide formation after exercise training in patients with metabolic syndrome

Cited by 65 publications

References 43 publications

The Effect of Acute and Chronic Moderate and High Intensity Aerobic Exercise on Serum Nitric Oxide in Untrained Overweight Males

The Effect of Acute and Chronic Moderate and High Intensity Aerobic Exercise on Serum Nitric Oxide in Untrained Overweight Males

Rapid Communication – Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetes

Time delay of baroreflex control and oscillatory pattern of sympathetic activity in patients with metabolic syndrome and obstructive sleep apnea

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