Enhanced efficacy and anti-biofilm activity of novel nanoemulsions against skin burn wound multi-drug resistant MRSA infections

Song, Zhen; Sun, Hongwu; Yang, Yun; Jing, Huaiqi; Yang, Liuyang; Tong, Yanan; Wei, Chao; Wang, Zelin; Zou, Quanming; Zeng, Hao

doi:10.1016/j.nano.2016.01.015

Cited by 60 publications

(36 citation statements)

References 22 publications

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“…The results showed that in comparison to the aqueous solution of the same drug, CNE had a better and faster action against MRSA and was more efficient at anti-biofilm activity (inhibiting biofilm formation and clearing the biofilm). Furthermore, CNE intensely disrupted cell walls and membranes of MRSA [58].…”

Section: Nanoemulsions (Ne)mentioning

confidence: 99%

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Souto

Ribeiro

Ferreira

et al. 2020

IJMS

102

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Burn wounds are highly debilitating injuries, with significant morbidity and mortality rates worldwide. In association with the damage of the skin integrity, the risk of infection is increased, posing an obstacle to healing and potentially leading to sepsis. Another limitation against healing is associated with antibiotic resistance mainly due to the use of systemic antibiotics for the treatment of localized infections. Nanotechnology has been successful in finding strategies to incorporate antibiotics in nanoparticles for the treatment of local wounds, thereby avoiding the systemic exposure to the drug. This review focuses on the most recent advances on the use of nanoparticles in wound dressing formulations and in tissue engineering for the treatment of burn wound infections.

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Section: Nanoemulsions (Ne)mentioning

confidence: 99%

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Souto

Ribeiro

Ferreira

et al. 2020

IJMS

102

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“…Use of natural and synthetic polymers as a potential dressing material to deliver different types of antimicrobials like antibiotics (ciprofloxacin, gentamicin, vancomycin, etc.) and antiseptic agent like silver, chlorhexidine acetate, and polyhexamethylene biguanide have been reported previously [2,5] (Table 1). Silver sulfadiazine a commonly used agent for burn wound treatment.…”

Section: Recent Drug-eluting Systemsmentioning

confidence: 80%

Recent developments in drug-eluting dressings for the treatment of chronic wounds

Kunjikuttan

Jayasree

Biswas

et al. 2016

Expert Opinion on Drug Delivery

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“…Another alternative is the use of nanotechnology, with delivery systems that concentrate and potentiate the antimicrobial effect 15 . Or even the reuse of drugs, used in traditional therapy, as proposed by Song et al, using a nanoemulsion of chlorhexidine, which seems to have quicker effect on the healing of skin lesions infected with reduced bacterial load and hindering the formation of biofilms 18 .…”

Section: ■ Discussionmentioning

confidence: 99%

Oxacillin magnetically targeted for the treatment of Methicillin-Resistant S. aureus infection in rats

et al. 2017

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Purpose: To evaluate the effect of oxacillin bonded to magnetic nanoparticles in local infection model in rat. Methods: Twelve Wistar rats weighing 290±18g were randomly divided into four groups (n=6, each) and all rats had a magnet ring sutured on their right thighs. In the biodistribution group rats 0.1mL of 99m Tc-magnetite (0.66 MBq) was injected i.v and after 30 minutes, biodistribution of 99m Tc-magnetite was evaluated in right and left thighs. The other groups were inoculated with MRSA in each thigh muscles. Group 1 rats were injected i.v. with magnetite, group 2 with Magnetite + Oxacillin, group 3 with saline twice a day. After 24 hours samples of muscle secretion were harvested for microbiological analysis; muscle, lungs and kidneys for histology. Results: 99m Tc-magnetite uptake was three-fold higher in right thigh muscles (with external magnet) than in the left. In magnetite and oxacillin-magnetite groups, bacterial/CFU was significantly lower in thigh muscles than in saline-controls. The inflammatory reaction in muscles and lungs was significantly lower in oxacillin-magnetite group-rats than in other groups (p<0.001). Conclusion: This study confirms the potential antimicrobial activity of magnetic nanoparticles for Methicillin-Resistant S. aureus strains, which in addition to concentrate the antibiotic at the infection site, positively influenced the treatment.

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Enhanced efficacy and anti-biofilm activity of novel nanoemulsions against skin burn wound multi-drug resistant MRSA infections

Cited by 60 publications

References 22 publications

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Recent developments in drug-eluting dressings for the treatment of chronic wounds

Oxacillin magnetically targeted for the treatment of Methicillin-Resistant S. aureus infection in rats

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