Enhanced Electrocatalytic Oxidation of Paracetamol at DNA Modified Gold Electrode

Althagafi, Ismail; Kassem, Mohammed A.; Awad, Mohamed I.

doi:10.1002/elan.201900141

Cited by 6 publications

(3 citation statements)

References 59 publications

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“…Electrocatalysis via DNA-mediated charge transport has been extensively studied and applied for the detection of lesions and mismatches in nonrepetitive DNA sequences . Recent examples have shown conversion of irreversible electrode kinetics of paracetamol to a quasi-reversible system and sequence-directed electrocatalytic reduction of ferricyanide at DNA-modified gold electrodes . Such interfacial charge transport property of DNA may be characterized as overlapping of the DNA base pair π-stacks with that of the interfacing materials .…”

Section: Resultsmentioning

confidence: 99%

Label-free Electrochemical Detection of CGG Repeats on Inkjet Printable 2D Layers of MoS₂

Asefifeyzabadi

Alkhaldi

Qamar

et al. 2020

ACS Appl. Mater. Interfaces

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Flexible and ultrasensitive biosensing platforms capable of detecting a large number of trinucleotide repeats (TNRs) are crucial for future technology development needed to combat a variety of genetic disorders. For example, trinucleotide CGG repeat expansions in the FMR1 gene can cause Fragile X syndrome (FXS) and Fragile X-associated tremor/ataxia syndrome (FXTAS). Current state-of-the-art technologies to detect repeat sequences are expensive, while relying on complicated procedures, and prone to false negatives. We reasoned that two-dimensional (2D) molybdenum sulfide (MoS2) surfaces may be useful for label-free electrochemical detection of CGG repeats due to its high affinity for guanine bases. Here, we developed a low-cost and sensitive wax-on-plastic electrochemical sensor using 2D MoS2 ink for the detection of CGG repeats. The ink containing few-layered MoS2 nanosheets was prepared and characterized using optical, electrical, electrochemical, and electron microscopic methods. The devices were characterized by electron microscopic and electrochemical methods. Repetitive CGG DNA was adsorbed on a MoS2 surface in a high cationic strength environment and the electrocatalytic current of the CGG/MoS2 interface was recorded using a soluble Fe(CN)6 –3/–4 redox probe by differential pulse voltammetry (DPV). The dynamic range for the detection of prehybridized duplexes ranged from 1 aM to 100 nM with a 3.0 aM limit of detection. A detection range of 100 fM to 1 nM was recorded for surface hybridization events. Using this method, we were able to observe selectivity of MoS2 for CGG repeats and distinguish nonpathogenic from disease-associated repeat lengths. The detection of CGG repeat sequences on inkjet printable 2D MoS2 surfaces is a forward step toward developing chip-based rapid and label-free sensors for the detection of repeat expansion sequences.

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Section: Resultsmentioning

confidence: 99%

Label-free Electrochemical Detection of CGG Repeats on Inkjet Printable 2D Layers of MoS₂

Asefifeyzabadi

Alkhaldi

Qamar

et al. 2020

ACS Appl. Mater. Interfaces

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“…There are PGE-based electrochemical (bio)sensor examples in the literature for the detection of PRL. [67][68][69][70][71] Ujwal et al 71 worked on the development of gadolinium ferrite/polyaniline (GdFeO 3 /PANI) modified PGE and used for the detection of PRL. They also used GdFeO 3 /PANI composite for photodegradation of PRL.…”

Section: Prl Concentration (μG MLmentioning

confidence: 99%

Fast, Cheap and Reliable Monitoring of Microalgae-Based Paracetamol Removal from Aquatic Environment Using Electrochemical Sensor Technology

Çongur¹,

Gül²,

Taştan³

2022

J. Electrochem. Soc.

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Paracetamol (PRL) is an analgesic and antipyretic drug, and its consumption has increased all across the world during the COVID-19 pandemic era. However, its excessive consumption makes it an endocrine-disrupting factor, and it is toxic for the liver. It easily contaminates water resources due to its high solubility, and has substantial potential to access both aquatic life and humans. Therefore, its removal by sustainable methods is a highlighted issue for today’s world that has experienced increasing scarcity of water. Herein, microalgae-based PRL removal and its electrochemical monitoring were performed. The removal performed with Scenedesmus sp. was monitored by disposable pencil graphite electrodes and cyclic voltammetry. The removal was achieved without the requirement of complex procedures, and the monitoring of this removal finished in less than 1 min. Application of the system in real life was tested in the presence of tap water. The biosorption kinetics, isoterms, and changes in chlorophyll content of microalgae were calculated, and the microscopic characterizations of the biosorption were performed. The selectivity of the system was studied against other water contaminants. This is the first study about the removal of PRL using Scenedesmus sp. and the monitoring of the removal using disposable electrochemical sensor technology.

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“…In contrast, electrochemistry with voltammetric platforms can provide sensitive and selective determination of drugs in pharmaceutical preparations and biological fluids without the requirement of extraction step [3]. Voltammetric platforms based on poly(EDOT)-poly(styren)-N-doped graphene/carbon nitride [4], Zn/Ni-ZIF and the electropolymerization of caffeic acid [5], poly(amidoamine)-Ag-CNTs/poly (neutral red) [6], polyimide-MWCNT [7], AuNPs/MWCNTs with thiolated calix [8]arene [8], poly(amido amine)-poly(Nile blue) [9], carbon blackpoly(acrylic acid)-La 2 O 3 [10], poly (rhodamine B) [11], Pd-graphene oxide [12], DNA [13], poly luminol-carbon nanotubes [14] were applied for the detection of paracetamol. Shi et.…”

Section: Introductionmentioning

confidence: 99%

A facile and sensitive method of analysis for the determination of paracetamol on a boron doped diamond electrode modified with carbon based nanomaterials

Kutluay Baytak,

Gezen,

Aslanoglu

2024

Electroanalysis

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This study presents the development of a facile and sensitive method of analysis for the determination of paracetamol. For this purpose, a boron doped diamond electrode (BDDE) was modified with a composite of carbon nanotubes (CNT), carbon nanofibers (CNF) and carbon black nanoballs (CNB). The voltammetric properties of paracetamol were studied, compared and discussed on unmodified BDDE, CNB/BDDE, CNF/BDDE, CNT/BDDE, CNB@CNF/BDDE, CNF@CNT/BDDE and CNF@CNB@CNT/BDDE. An increase in peak response (Ip) and a dramatic decrease in peak separation (ΔEp) were observed at electrodes in an order from bare BDDE to CNB/BDDE, CNF/BDDE, CNT/BDDE, CNB@CNF/BDDE, CNF@CNT/BDDE and CNF@CNB@CNT/BDDE. This clearly showed that the composite material of CNF@CNB@CNT provided an excellent surface on BDDE leading to a fast electrode reaction of paracetamol. Interestlingly, the amount composite layer on the voltammetry of paracetamol also caused a remarkable decrease in ΔEp and resulted in high electrocatalytic activity. The detection of paracetamol based on the BDDE modified with a composite of CNF@CNB@CNT exhibited stability, excellent selectivity and good sensitivity, with a low detection limit of 0.47±0.002 nM (based on 3sb/m) and wide linear range of 1.5 nM–200 nM. These results demonstrate that CNF@CNB@CNT/BDDE can serve as an ideal voltammetric platform for constructing a paracetamol sensor. The proposed electrochemical platform (CNF@CNB@CNT/BDDE) was also successfully applied for the determination of paracetamol in pharmaceuticals and body fluids.

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Enhanced Electrocatalytic Oxidation of Paracetamol at DNA Modified Gold Electrode

Cited by 6 publications

References 59 publications

Label-free Electrochemical Detection of CGG Repeats on Inkjet Printable 2D Layers of MoS₂

Label-free Electrochemical Detection of CGG Repeats on Inkjet Printable 2D Layers of MoS₂

Fast, Cheap and Reliable Monitoring of Microalgae-Based Paracetamol Removal from Aquatic Environment Using Electrochemical Sensor Technology

A facile and sensitive method of analysis for the determination of paracetamol on a boron doped diamond electrode modified with carbon based nanomaterials

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Enhanced Electrocatalytic Oxidation of Paracetamol at DNA Modified Gold Electrode

Cited by 6 publications

References 59 publications

Label-free Electrochemical Detection of CGG Repeats on Inkjet Printable 2D Layers of MoS2

Label-free Electrochemical Detection of CGG Repeats on Inkjet Printable 2D Layers of MoS2

Fast, Cheap and Reliable Monitoring of Microalgae-Based Paracetamol Removal from Aquatic Environment Using Electrochemical Sensor Technology

A facile and sensitive method of analysis for the determination of paracetamol on a boron doped diamond electrode modified with carbon based nanomaterials

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Product

Resources

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Label-free Electrochemical Detection of CGG Repeats on Inkjet Printable 2D Layers of MoS₂

Label-free Electrochemical Detection of CGG Repeats on Inkjet Printable 2D Layers of MoS₂