Enhanced Expression of p53 Protein in Pityriasis Rubra Pilaris

Baran, Wojciech; Szepietowski, Jacek C.; Szybejko-Machaj, G

doi:10.2340/00015555-0064

Cited by 22 publications

(31 citation statements)

References 9 publications

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“…Baima and Sticherling 8 have demonstrated that the marked reduction of Bcl‐2 expression in the basal cells of cutaneous LE lesions is associated with the overexpression of Fas antigen. Whereas in psoriasis patients a marked increase of p53+ and CD8+ cells is usually observed in lesional epidermis, our patient with APF did not show marked changes in expression of these proteins 6,9 . Hence, our data indicate that the expression profiles of CD8, Bcl‐2, and p53 found in APF lesions differ from those usually observed in psoriasis and LE.…”

Section: Reportcontrasting

confidence: 64%

Immunohistology of amicrobial pustulosis of the folds

et al. 2007

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Amicrobial pustulosis of the folds (APF), is a rare pustular eruption, predominantly involving the cutaneous folds, the external auditory canals and the scalp, occurring in patients who exhibit a wide spectrum of autoimmune abnormalities. There is a lack of data on the immunohistology of APF. We report a new case of APF associated with features of systemic lupus erythematosus (LE). Extensive immunohistological examinations of lesional and nonlesional skin were performed. The results of our immunohistological studies indicate that immunostaining with p53, Bcl-2, and CD8 antigens could be useful in differentiating APF from closely related inflammatory conditions such as psoriasis and cutaneous LE. However, studies on a larger sample size including controls are needed to substantiate our findings.

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Section: Reportcontrasting

confidence: 64%

Immunohistology of amicrobial pustulosis of the folds

et al. 2007

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“…The tumour suppressor p53 is upregulated in the pathogenesis of human chronic plaque‐type psoriasis (Fig. a), and its role in skin disease has long been questioned . In additional animal studies, p53 has been found to be largely dispensable to epidermal homeostasis, with gene loss only causing minor alterations in murine catagen, and paradoxically, p53 deletion reduces oncogenesis in transgenic mouse skin carcinogenesis studies .…”

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confidence: 99%

p53 activity contributes to defective interfollicular epidermal differentiation in hyperproliferative murine skin

et al. 2015

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“…In psoriasis lesions, elevated p53 accumulation has been reported (9,10), and following NB-UVB phototherapy, an increase in p53 expressing keratinocytes has been seen (11). Many studies have focused on p53 transcription factor, because of its pivotal role in triggering cell cycle arrest or inducing apoptosis in cells damaged by UV irradiation.…”

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confidence: 99%

Effect of Narrow-band Ultraviolet B Phototherapy on p63 and MicroRNA (miR-21 and miR-125b) Expression in Psoriatic Epidermis

Gu¹,

Nylander²,

Coates³

et al. 2011

Acta Derm Venerol

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Psoriasis is an inflammatory skin disease in which dysregulation of p63, a member of the p53 family that is crucial for skin development and maintenance, has been demonstrated. Involvement of miR-203, miR-21 and miR-125b, small non-coding RNAs implicated in the regulation of p63 or p53, has been suggested in the patho-genesis of psoriasis. To elucidate the roles of p63 and p63-related microRNAs in psoriasis and to increase our understanding of the mechanisms of narrow-band ultraviolet B (NB-UVB) phototherapy, we studied the effects of NB-UVB treatment on the expression of these molecules. Skin biopsies from 12 psoriasis patients were collected before, during and after NB-UVB therapy. Real-time PCR and immunohistochemistry showed that p63 expression was not significantly affected, whereas NB-UVB phototherapy significantly decreased expression of miR-21 (p = 0.003) and increased miR-125b levels (p = 0.003). The results indicate that the unresolved p63 abnormality in treated epidermis may play a role in maintenance of this disease.

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Enhanced Expression of p53 Protein in Pityriasis Rubra Pilaris

Cited by 22 publications

References 9 publications

Immunohistology of amicrobial pustulosis of the folds

Immunohistology of amicrobial pustulosis of the folds

p53 activity contributes to defective interfollicular epidermal differentiation in hyperproliferative murine skin

Effect of Narrow-band Ultraviolet B Phototherapy on p63 and MicroRNA (miR-21 and miR-125b) Expression in Psoriatic Epidermis

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