Enhanced fitness and renal function in Type 2 diabetes

Nylen, Eric; Gandhi, Shruti M.; Kheirbek, Raya; Kokkinos, Peter

doi:10.1111/dme.12789

Cited by 23 publications

(44 citation statements)

References 21 publications

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“…Although studies have not adequately examined effects of exercise on cardiovascular outcomes, exercise does appear to improve lipid metabolism. 80,81 …”

Section: Frailty In the Ckd And Esrd Populationmentioning

confidence: 99%

“…Forty-two percent of those with CKD 3 (16 of 38), improved to CKD 1 or 2 after the intervention. 80 A third randomized controlled trial of physical training (either 30 minutes of daily bicycling or equivalent physical activity) vs. maintenance of usual lifestyle in 30 patients with median eGFR of 25 mL/min/1.73m 2 showed improvement in maximal work capacity, but did not show change in rate of progression of GFR over the 20-month follow-up period. 89 …”

Section: Frailty In the Ckd And Esrd Populationmentioning

confidence: 99%

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Prehabilitation for the Frail Patient Approaching ESRD

Sheshadri

Johansen

2017

Seminars in Nephrology

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Frailty is a distinct phenotype that is highly prevalent in chronic kidney disease (CKD) and appears to be more prevalent with declining GFR. Exercise training or intervention to increase physical activity may ameliorate poor physical functioning and frailty, and may even improve survival in patients with CKD. Although exercise interventions improve outcomes across the spectrum of CKD, including patients treated with dialysis, patients treated with dialysis face barriers to exercise that patients with pre-dialysis CKD do not. Rehabilitation at earlier stages of CKD (or “prehabilitation” before dialysis) might be more beneficial than not addressing the declining physical functioning and low physical activity until patients are receiving dialysis. This review summarizes available literature on frailty in the CKD and ESRD population, including exercise interventions and the limited evidence for “prehabilitation” as a strategy.

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“…Although studies have not adequately examined effects of exercise on cardiovascular outcomes, exercise does appear to improve lipid metabolism. 80,81 …”

Section: Frailty In the Ckd And Esrd Populationmentioning

confidence: 99%

Section: Frailty In the Ckd And Esrd Populationmentioning

confidence: 99%

Prehabilitation for the Frail Patient Approaching ESRD

Sheshadri

Johansen

2017

Seminars in Nephrology

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“…19,20 Clinical data support the positive effects of exercise training in chronic kidney disease patients, but its consequent translation into clinical practice must be improved and further research in this field is certainly needed. [19][20][21][22][23]…”

Section: Physical Exercise and Exercise Tolerancementioning

confidence: 99%

Accelerated renal function decline in obese post myocardial infarction patients – is weight reduction per se an adequate therapeutic consequence?

Rauch

2017

Eur J Prev Cardiolog

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“…There are many papers in which even diabetic patients with renal failure were improved at a certain level by exercise, (17,18) while there are other opinions that the exercise strength should be more systematically customized and optimized for each patient. (19,20) Therefore, in this study, we tried to examine the merits and demerits of exercise effect under the different physiological and pathophysiological condition for the purpose to spread a wide T target. To this end, we used rats with the duplicative state of renal failure and diabetes mellitus (DM) and compared several parameters with healthy animals, where renal failure model was induced by single injection of vancomycin and, obesity and glucose intolerance were induced by a high-fructose diet (HF).…”

mentioning

confidence: 99%

Bright and dark sides of exercise effects on biological responses such as energy metabolism and renal function in rats with renal failure and fructose-induced glucose intolerance

Miya

Naito

Chikamoto

et al. 2020

J. Clin. Biochem. Nutr.

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In the present study, we investigated the beneficial and risky effects of exercise intended to prevent or treat lifestyle related diseases on insulin sensitivity, lactic acid utilization, lipid metabo lism, hepatic and renal oxidative stress, hepatic selenoprotein P and renal function in obese and glucose intolerant rats with renal failure. We fed normal rats a 20% casein diet while the glucose intolerant, obese rats received a high fructose diet, and after then rats received single injection of vancomycin at a dose of 400 mg/kg for constructing the duplicative state of renal failure and diabetes mellitus. They were forced to run for 1 h/day, 6 days/week, for 10 weeks. Exercise reduced visceral fat and ameliorated insulin sensi tivity in the high fructose group, improved lactic acid usage efficiency, however, increased hepatic oxidative stress and com plicated renal dysfunction in the normal and high fructose fed groups with renal failure. Additionally, exercise upregulated hepatic selenoprotein P expression and enhanced renal antioxida tive system in both groups. It is concluded that strictly controlled exercise conditions must be adapted to patient health states especially in view of kidney protection, and supplemental therapy is also recommended in parallel with exercise, using nutrients and vitamins for kidney protection.

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Enhanced fitness and renal function in Type 2 diabetes

Cited by 23 publications

References 21 publications

Prehabilitation for the Frail Patient Approaching ESRD

Prehabilitation for the Frail Patient Approaching ESRD

Accelerated renal function decline in obese post myocardial infarction patients – is weight reduction per se an adequate therapeutic consequence?

Bright and dark sides of exercise effects on biological responses such as energy metabolism and renal function in rats with renal failure and fructose-induced glucose intolerance

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