2022
DOI: 10.1038/s41419-022-04541-1
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Enhanced glycolysis in granulosa cells promotes the activation of primordial follicles through mTOR signaling

Abstract: In mammals, nonrenewable primordial follicles are activated in an orderly manner to maintain the longevity of reproductive life. Mammalian target of rapamycin (mTOR)-KIT ligand (KITL) signaling in pre-granulosa cells and phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt)-forkhead Box O3a (FOXO3a) signaling in oocytes are important for primordial follicle activation. The activation process is accompanied by the enhancement of energy metabolism, but the causal relationship is unclear. In the present stu… Show more

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Cited by 62 publications
(43 citation statements)
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“…Glycolysis are essential for ovarian development and homeostasis provide nutrients and mechanical support for oocytes via physical interactions 32 . Due to glycolysis-related apoptosis of GCs often causes follicular atresia and ovarian aging 33 , we focused on the glycolysis-associated changes of gene expression in ovarian. Expression and protein levels of these glycolysis-associated genes were also decreased in aging ovarian cells in comparison with ovarian cells from young ovaries (Fig.4a-e).…”
Section: Resultsmentioning
confidence: 99%
“…Glycolysis are essential for ovarian development and homeostasis provide nutrients and mechanical support for oocytes via physical interactions 32 . Due to glycolysis-related apoptosis of GCs often causes follicular atresia and ovarian aging 33 , we focused on the glycolysis-associated changes of gene expression in ovarian. Expression and protein levels of these glycolysis-associated genes were also decreased in aging ovarian cells in comparison with ovarian cells from young ovaries (Fig.4a-e).…”
Section: Resultsmentioning
confidence: 99%
“…Glycolysis-related proteins were upregulated in GCs during the primordial-to-primary follicle transition, indicating glycolytic activity in GCs is vital for the development of growing follicles. [ 45 ] Several studies have presented evidence directly linking O-GlcNAcylation to the regulation of key glycolytic enzymes [ 10 ]. For instance, O-GlcNAcylation inhibits phosphofructokinase 1 (PFK1) activity and redirects glucose flux through the PPP, which provides the reducing power critical for cancer cell proliferation and survival [ 46 ].…”
Section: Discussionmentioning
confidence: 99%
“…And YAP could promote glycolysis, lipogenesis, and glutaminolysis to maintain cell homeostasis [38] . As the main energy source for the follicle development, glycolysis occurred and enhanced in granulosa cells during the follicle activation [39] . Then we speculate that the FTO/YAP axis may protect granulosa cells from cisplatin -induced injury via regulating the metabolic levels of injured granulosa cell.…”
Section: Discussionmentioning
confidence: 99%