Enhanced Hoffman-reflex in human soleus muscle during exposure to microgravity environment

Nomura, Takeshi; Kawano, Fuminori; Ishihara, Akihiko; Sato, Yuzo; Mitarai, Genyo; Iwase, Satoshi; Kamiya, Atsunori; Mano, Tadaaki; Ohira, Yoshinobu

doi:10.1016/s0304-3940(01)02367-9

Cited by 14 publications

(18 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to the abovementioned molecular and cellular experiments, a variety of studies have been conducted to investigate the effect of gravity on the nervous system in humans [4,10,[30][31][32][33][34]. In the context of movement control, it becomes apparent that the biophysical attributes underlying cell communication and the nervous capacity to inhibit and facilitate neural pathways are of fundamental importance to activate and control the skeletal muscle, allowing the living organisms to displace themselves.…”

Section: The Gravity Dependence Of the Human Nervous Systemmentioning

confidence: 99%

“…The H-reflex amplitude describes the neuronal output signal of the reflectory reaction of muscles and is proportional to the muscle contraction after peripheral electrical stimulation of sensory fibers in their innervating nerves. Gravity dependency has been reported in crosssectional study designs with neuroplastic changes for amplitudes of H-reflexes and stretch reflexes [10,[30][31][32][33][34]. The peak-to-peak amplitudes increased during hypergravity, independently from the method of stimulation [10,33].…”

Section: Amplitude Of the H-reflexmentioning

confidence: 99%

“…Less gravity resulted in a higher decrease in Hmax amplitude [4]. Nevertheless, in microgravity, the H-reflex was either not changed [10,34] or it was increased [30][31][32][33]. A longterm experiment on the International Space Station (ISS) revealed a decrease of H-reflexes in space [38].…”

Section: Amplitude Of the H-reflexmentioning

confidence: 99%

“…The amplitudes of the different sections of the H-reflex depend on the stimulation threshold. As the threshold is gravity-dependent, this has to be taken into account when a constant stimulus intensity is used during the experiments [30][31][32][33]. H/M-wave recruitment curves are independent of stimulation threshold [10,34].…”

Section: Amplitude Of the H-reflexmentioning

confidence: 99%

“…H/M-wave recruitment curves are independent of stimulation threshold [10,34]. As a consequence, gravity-induced changes in H-reflex amplitudes elicited with a constant and submaximal stimulus are rather attributed to threshold shifts than changes in gravity [30][31][32][33].…”

Section: Amplitude Of the H-reflexmentioning

confidence: 99%

See 4 more Smart Citations

The Effect of Gravity on the Nervous System

Kohn¹,

Koch²,

Ritzmann³

2018

Into Space - A Journey of How Humans Adapt and Live in Microgravity

View full text Add to dashboard Cite

Gravity affects the nervous system of living organisms. This book chapter reviews historical and recent findings on how changes in gravity affect cellular and subcellular parameters of human and animal cells as well as the timing and shaping of complex sensorimotor responses. With an emphasize on weightlessness, partial, and hypergravity conditions, the gravity dependencies of living organisms have been manifested on different levels of organization, ranging from changes in biophysical properties of single cells to the intact nervous system. An effort has been made to integrate the various findings into a consistent model for a better understanding of how the components of the nervous system interact as a response to acute and long-term gravitational variation. Especially with planned long-term manned missions to Mars and beyond, knowledge about the impact of increased and decreased gravity on the nervous system is essential for the physical and cognitive preparation to assure the success of space missions and human survival in space.

show abstract

Section: The Gravity Dependence Of the Human Nervous Systemmentioning

confidence: 99%

Section: Amplitude Of the H-reflexmentioning

confidence: 99%

Section: Amplitude Of the H-reflexmentioning

confidence: 99%

Section: Amplitude Of the H-reflexmentioning

confidence: 99%

Section: Amplitude Of the H-reflexmentioning

confidence: 99%

See 3 more Smart Citations

The Effect of Gravity on the Nervous System

Kohn¹,

Koch²,

Ritzmann³

2018

Into Space - A Journey of How Humans Adapt and Live in Microgravity

View full text Add to dashboard Cite

show abstract

Gravity and neuronal adaptation, in vitro and in vivo—from neuronal cells up to neuromuscular responses: a first model

Kohn

Ritzmann

2017

Eur Biophys J

View full text Add to dashboard Cite

For decades it has been shown that acute changes in gravity have an effect on neuronal systems of human and animals on different levels, from the molecular level to the whole nervous system. The functional properties and gravity-dependent adaptations of these system levels have been investigated with no or barely any interconnection. This review summarizes the gravity-dependent adaptation processes in human and animal organisms from the in vitro cellular level with its biophysical properties to the in vivo motor responses and underlying sensorimotor functions of human subjects. Subsequently, a first model for short-term adaptation of neuronal transmission is presented and discussed for the first time, which integrates the responses of the different levels of organization to changes in gravity.

show abstract