Enhanced impregnation of hydrogel contact lenses with salicylic acid by addition of water in supercritical carbon dioxide

Yokozaki, Yuta; Sakabe, Jun‐ichi; Shimoyama, Yusuke

doi:10.1016/j.cherd.2015.08.007

Cited by 14 publications

(4 citation statements)

References 20 publications

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“…Derivate from the soaking technique, the supercritical CO 2 impregnation/dispersion method is also explored due to its non-toxicity, its low surface tension of the polymer and its high diffusivity [ 109 ]. This technique permits to prepare commercial soft contact lenses such as FocusDailies ® (Novartis, Basel, Switzerland), Proclear ® Compatibles (CooperVision, Lake Forest, CA, USA), Frequency ® 55 (CooperVision, Lake Forest, CA, USA) and SofLens ® 59 Comfort (Bausch & Lomb, Rochester, NY, USA).…”

Section: Recent Advances For Ocular Antibiotics Administrationmentioning

confidence: 99%

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

et al. 2018

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The last fifty years, ophthalmic drug delivery research has made much progress, challenging scientists about the advantages and limitations of this drug delivery approach. Topical eye drops are the most commonly used formulation in ocular drug delivery. Despite the good tolerance for patients, this topical administration is only focus on the anterior ocular diseases and had a high precorneal loss of drugs due to the tears production and ocular barriers. Antibiotics are popularly used in solution or in ointment for the ophthalmic route. However, their local bioavailability needs to be improved in order to decrease the frequency of administrations and the side effects and to increase their therapeutic efficiency. For this purpose, sustained release forms for ophthalmic delivery of antibiotics were developed. This review briefly describes the ocular administration with the ocular barriers and the currently topical forms. It focuses on experimental results to bypass the limitations of ocular antibiotic delivery with new ocular technology as colloidal and in situ gelling systems or with the improvement of existing forms as implants and contact lenses. Nanotechnology is presently a promising drug delivery way to provide protection of antibiotics and improve pathway through ocular barriers and deliver drugs to specific target sites.

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Section: Recent Advances For Ocular Antibiotics Administrationmentioning

confidence: 99%

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

et al. 2018

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“…The supercritical fluid impregnation process has been successfully applied to the elaboration of ophthalmic localized sustained-release drug delivery intraocular lenses or contact lenses (Braga et al, 2011;Costa et al, 2010;Dias et al, 2011;Duarte et al, 2007Duarte et al, , 2008Bouledjouidja et al, 2016Bouledjouidja et al, , 2017bMasmoudi et al, 2011;Yokozaki et al, 2015aYokozaki et al, , 2015bYokozaki and Shimoyama, 2018). Some of these studies feature the feasability of obtaining effective and in-depth impregnation within these sensitive medical devices without altering their thermomechanical, surface/wettability, oxygen permeability and optical properties (Masmoudi et al, 2011;Braga et al, 2011;Bouledjouidja et al, 2017aBouledjouidja et al, , 2017bCosta et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Supercritical loading of gatifloxacin into hydrophobic foldable intraocular lenses – Process control and optimization by following in situ CO2 sorption and polymer swelling

Ongkasin

Masmoudi²,

Tassaing³

et al. 2020

International Journal of Pharmaceutics

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The supercritical impregnation process was used as a green technology for the elaboration of drug delivery intraocular lenses to mitigate the risk of post-operatory endophthalmitis after cataract surgery. Commercially available hydrophobic acrylic (copolymer of benzyl methacrylate and methyl methacrylate) intraocular lenses (IOLs) were impregnated with gatifloxacin, a fourth generation fluoroquinolone drug, using pure supercritical CO 2 (scCO 2 ) to obtain solvent-free loaded implants. The interaction phenomena involved in the supercritical impregnation were studied by following in situ scCO 2 sorption within the polymer support and the subsequent IOL swelling, and by taking into account drug solubility in the supercritical fluid phase. The drug impregnation yields determined though in-vitro release studies varied between 0.33 and 1.07 ± 0.07 μg•mg −1 IOL in the studied experimental conditions (8 to 25 MPa, 308 to 328 K and 30 to 240 min impregnation duration). An impregnation duration longer or equal to the time required for a complete CO 2 uptake by the polymer as well as a higher pressure or a higher temperature over the crossover pressure delimiting the upper limit of the retrograde solubility zone, led to higher drug impregnation yields.

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“…As the main product of fuel combustion, a huge amount of CO 2 is being released through industrial activities. Although soil, plants, oceans, and rivers in the natural carbon cycle can all absorb CO 2 , there is an urgent need to develop effective and sustainable techniques to reduce and reuse CO 2 in other applications. , Supercritical CO 2 , for example, can be applied in many potential applications such as fabrication process of porous materials, , drug delivery systems, − and nanosuspensions. , Carbon dioxide can be used for switching polarity, hydrophilicity, or ionic strength of a solvent. − Activated polymer systems by CO 2 have been reported by some research groups. − Nagai et al investigated the reactions between CO 2 and amines to form reversible cross-linked carbamate polymers. Han et al , have also presented the modification of lower critical solution temperature of polymers activated by CO 2 .…”

Section: Introductionmentioning

confidence: 99%

CO₂-Activated Adsorption: A New Approach to Dye Removal by Chitosan Hydrogel

et al. 2018

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This study focuses on development of a new adsorption technique by CO 2 -activated chitosan. Carbon dioxide was utilized to form the functional chemical groups of chitosan on the adsorptions of anionic dyes, Brilliant Blue FCF and Congo Red, in the aqueous solution. CO 2 -activated chitosan results in the dye adsorption significantly faster than that of chitosan in pure water. The adsorption capacities and removal efficiencies of the dye are increased by CO 2 -activated chitosan. Furthermore, the dye adsorptions on CO 2 -activated chitosan were investigated at various temperatures and initial dye concentrations in the aqueous solution. Interestingly, the high temperature adsorption provides the enhancement of adsorption capacities and removal efficiencies of the dye by the carbamate cross-linking of chitosan with CO 2 . CO 2 -activated chitosan was further characterized by Fourier transform infrared spectra, amino group ratio, zeta potential, and thermal gravimetric analysis. These characterizations can be used for understanding the unique adsorption of the dye on CO 2 -activated chitosan. Carbon dioxide-activated chitosan in this work will provide an effective operation and a clean process of dye adsorption in wastewater treatment.

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Enhanced impregnation of hydrogel contact lenses with salicylic acid by addition of water in supercritical carbon dioxide

Cited by 14 publications

References 20 publications

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

Supercritical loading of gatifloxacin into hydrophobic foldable intraocular lenses – Process control and optimization by following in situ CO2 sorption and polymer swelling

CO₂-Activated Adsorption: A New Approach to Dye Removal by Chitosan Hydrogel

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Enhanced impregnation of hydrogel contact lenses with salicylic acid by addition of water in supercritical carbon dioxide

Cited by 14 publications

References 20 publications

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

Supercritical loading of gatifloxacin into hydrophobic foldable intraocular lenses – Process control and optimization by following in situ CO2 sorption and polymer swelling

CO2-Activated Adsorption: A New Approach to Dye Removal by Chitosan Hydrogel

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Product

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CO₂-Activated Adsorption: A New Approach to Dye Removal by Chitosan Hydrogel