Enhanced inflammatory hyperalgesia after recovery from burn injury

Summer, Gretchen J.; Dina, Olayinka A.; Levine, Jon D.

doi:10.1016/j.burns.2007.02.007

Cited by 35 publications

(24 citation statements)

References 33 publications

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“…Studies of nerve fibers in burn patients with chronic pain revealed an increase in nociceptive nerve fibers in burn scars. 8,9 Similar findings were observed in nerves in uninjured sites, indicating the existence of a systemic process that is activated by the cutaneous injury. Most likely, the interplay between wounding, healing, and remodeling, at the interface between skin and subcutaneous structures, results in chronic neuropathic pain after burn injuries.…”

supporting

confidence: 81%

Fat Grafting for Neuropathic Pain After Severe Burns

Fredman

Edkins

Hultman

2016

Annals of Plastic Surgery

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supporting

confidence: 81%

Fat Grafting for Neuropathic Pain After Severe Burns

Fredman

Edkins

Hultman

2016

Annals of Plastic Surgery

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“…[28][29][30] However, in chronic nonhealing wounds, a sustained release of pain mediators can create an imbalance that favors extended inflammation, excessive matrix metalloproteinase release, and extensive breakdown of extracellular matrix. [28][29][30][31][32][33][34] This can delay healing or complicate the underlying disease process. The complex changing relationship between inflammatory process and wound healing needs to be addressed.…”

Section: Discussionmentioning

confidence: 99%

Preventing, minimizing, and managing pain in patients with chronic wounds: challenges and solutions

Serena

Yaakov²,

Aslam³

et al. 2016

CWCMR

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Abstract:It is widely known that pain frequently accompanies certain types of chronic wounds, most notably arterial insufficiency ulcers, venous leg ulcers, and diabetic foot ulcers; however, until recently, pain associated with chronic wounds has not received much attention. A limited number of studies have explored the impact of painful wounds on the quality of life. Nonetheless, these early works have brought wound-related pain (WRP) to the forefront and highlighted the importance of pain assessment and management in enhancing the quality of life and improving wound healing outcomes. This review of the current literature on WRP presents an overview of pain pathophysiology, clinical features of WRP, and the limitations of pain assessment methods, and offers clinical pearls on preventing, managing, and minimizing WRP.

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“…Due to the MNT differences observed between sham and actual dehorned calves throughout the study period, MNT appears to be a reliable measure of increased pain sensitivity associated with cautery dehorning. Although MNT did not return to baseline values following the duration of the study (4 d) for dehorned calves, partial thickness epidermal burns have been noted to induce mechanical hyperalgesia for up to 4 wk in rat thermal injury models (Summer et al, 2007).…”

Section: Mechanical Nociception Thresholdmentioning

confidence: 99%