Enhanced nephrotoxicity of acetaminophen in fructose-induced hypertriglyceridemic rats: Effect of partial hepatectomy

Diabetes and hypertriglyceridemia modify the mode of acetaminophen-induced hepatotoxicity and nephrotoxicity in rats and mice

“…Therefore, they indicated that enhanced susceptibility to APAP-induced nephrotoxicity in fructose-pretreated rats may be due, at least in part, to increased renal APAP concentration and increased susceptibility to its nephrotoxic metabolite. In addition, partial hepatectomy (70% or 90%) did not potentiate APAP-induced nephrotoxicity or renal APAP concentration, and fructose-pretreated rats showed more severe renal lesions and greater renal APAP concentration than non-pretreated rats irrespective of partial hepatectomy, indicating that an increase in renal APAP concentration in the fructose-pretreated rats is not related to an alteration in hepatic metabolic capacity of APAP (Ishida et al, 1997c).…”