Enhanced osteoblast functions of narrow interligand spaced Sr-HA nano-fibers/rods grown on microporous titania coatings

Han, Yong; Zhou, Jianhong; Lu, Shemin; Zhang, Lan

doi:10.1039/c3ra23425h

Cited by 44 publications

(37 citation statements)

References 55 publications

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“…For ordered patterns, integrin ligands with a lateral spacing larger than 70 nm inhibited focal adhesion formation and cell spreading. 30 In the present work, the HA nanorods on the HT3h coating are quasi-upright oriented with a disordered pattern and an interrod spacing of 68.1 AE 7.1 nm. 25,52 Our previous studies of Sr-HA patterned coatings on Ti also depicted that the formation of focal adhesion was significantly enhanced on the o96 nm spaced nanorod patterned 3D topographies and more pronounced with decreasing interrod spacing, but inhibited on the 496 nm spaced nanorods compared to the nanogranulated 2D topography 32 and flat Ti.…”

Section: Adhesion and Proliferation Of Osteoblasts On The Coatingsmentioning

confidence: 61%

“…21 The surface features of implanted materials, such as chemical composition and topography, are recognized as crucial factors in regulating cell behaviors and bone tissue response. [30][31][32] Recent studies also demonstrated that the 3D topography of material surfaces could separately influence the behavior of cells; however, conflicting results have been reported. However, as an analogous substance to sodium tantalate, sodium titanate was reported to reveal lower proliferation and differentiation of osteoblasts than HA.…”

Section: Introductionmentioning

confidence: 99%

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Formation and osteoblast behavior of HA nano-rod/fiber patterned coatings on tantalum in porous and compact forms

2015

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The novel bilayered coatings, comprising hydroxyapatite (HA) nano-rods/fibers as an outer-layer and the CaTa 2 O 6 -based matrix as an inner-layer, were fabricated on Ta in porous and compact forms using microarc oxidation and hydrothermal treatment (HT). The formation mechanism and change in the topography of the HA nano-rods/fibers were investigated. Moreover, the evolution of structure and adhesive strength, apatite-inducing ability, and cytocompatibility of the nano-rod/fiber patterned coatings together with Ta were also explored. During HT, the HA nanorods directly nucleated on the CaTa 2 O 6 -based matrix and grew in length to nanofibers with HT time. Meanwhile, the orientation of the nano-rods/fibers on the resultant HT3h, HT6h and HT24h coatings also changed, appearing to be quasi-vertical, bent, and parallel to the underlying substrate, respectively, corresponding to the widening of inter-rod/fiber spacing. The coatings adhered firmly to Ta substrates with long-term adhesive strength stability, and exhibited a superior apatite-inducing ability. The survival and proliferation of osteoblasts were significantly enhanced on the quasi-upright HA nanorod patterned HT3h coating, however, greatly inhibited on the paralleled HA nanofiber patterned HT24h coating compared to Ta. The difference may have resulted from the stable cell adhesion on the HT3h coating and enhanced cell apoptosis caused by unstable cell adhesion on the HT24h coating, owing to the narrow interrod spacing for the former and the wide interfiber spacing for the latter. † Electronic supplementary information (ESI) available: Surface and crosssectional morphologies of the MAOed compact Ta discs before and after HT for 3, 6 and 24 h; curves of acoustic output versus load and scratch images of the MAO 0 coating un-immersed and immersed for 20 weeks, the HT3h coating unimmersed and immersed for 20 weeks, and the un-immersed HT24h coating, together with the amplified views of the L c -caused failure areas as well as the EDX spectra detected in the delaminating regions of the coatings. See

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Section: Adhesion and Proliferation Of Osteoblasts On The Coatingsmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Formation and osteoblast behavior of HA nano-rod/fiber patterned coatings on tantalum in porous and compact forms

2015

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“…20 A series of interactions will occur between the implant surface and the physiological environment after implantation into the human body. [29][30][31][32] However, to our knowledge, it is rare to use Sr-substituted implants together with micro/nanotopography to investigate the bone formation and osseointegration in osteoporotic bones in current research, though there have been some previous studies of Sr-doped implants in vivo. The performance of artificial implants mainly depends upon the surface characteristics such as topography and composition.…”

Section: Introductionmentioning

confidence: 99%

Strontium delivery on topographical titanium to enhance bioactivity and osseointegration in osteoporotic rats

Wen

Pan

et al. 2015

J. Mater. Chem. B

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Strontium delivery on topographical titanium to enhance bioactivity and osseointegration in osteoporotic ratsThis work completed by Wen Jin, Li Jinhua et al. indicated that a topographical titanium surface with substituted strontium could promote osteogenic diff erentiation, inhibit osteoclast formation in vitro and have a good osseointegration eff ect in osteoporotic rats. 4790 | J. Mater. Chem. B, 2015, 3, 4790--4804 This journal is Osseointegration remains a major clinical challenge in osteoporotic patients. Strontium (Sr) has been shown to be a significant therapy to favor bone growth by both increasing new bone formation and reducing bone resorption. In this study, we attempt to chemically functionalize Ti implants by micro-arc oxidation, alkali treatment and ion exchange. This functionalized Ti surface possessed a hierarchical topography with Sr incorporation, which can release Sr ions at a slow rate. To our knowledge, this work is the first to use this type of Sr-doped Ti surface to address osteoporotic bone mesenchymal stem cells (BMSCs) in the dual directions of bone regeneration, bone formation and bone resorption. The modified surface was demonstrated to remarkably enhance the adhesion, spreading, and osteogenic differentiation of BMSCs in vitro. The effect of the wash-out solution from various groups on osteoporotic BMSCs was also investigated. The Sr-doped group can improve the ALP activity and osteogenic gene expression.Moreover, the Sr-doped group and the wash-out solution show the most inhibition in osteoclast formation and maturation. Furthermore, the increased bioactivity of the hierarchical structure was also confirmed with the ovariectomized rat femur model in vivo. The outcome of fluorescence labeling, histology and histomorphometric analysis demonstrated a significant promotion of osseointegration in ovariectomized rats. Altogether, the experimental data indicate that the fabrication of a Sr-doped hierarchical Ti surface is a meaningful attempt to incorporate the Sr nutrient element into Ti-based implants, and it is expected to be exploited in developing better osseointegration for osteoporotic patients.

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“…Zhang et al [39] suggested that porous and micron-sized crystals on surface of implant materials are beneficial to enhance the osteoblast adhesion and growth. Recently, it was shown that the presence of small HA nanoplates on the surface of implant materials enhanced the tissue adhesion and cell formation [39,59,60]. The SEM images also illustrated that the surface of the coated samples had macro-and microcracks which is due to formation of thermal stress and high energy discharges during the oxidation process (Fig 3A-B).…”

Section: Surface Morphology and Chemical Analysismentioning

confidence: 83%

Direct fabrication of crystalline hydroxyapatite coating on zirconium by single-step plasma electrolytic oxidation process

Cengiz

Uzunoğlu

Stanciu

et al. 2016

Surface and Coatings Technology

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Enhanced osteoblast functions of narrow interligand spaced Sr-HA nano-fibers/rods grown on microporous titania coatings

Cited by 44 publications

References 55 publications

Formation and osteoblast behavior of HA nano-rod/fiber patterned coatings on tantalum in porous and compact forms

Formation and osteoblast behavior of HA nano-rod/fiber patterned coatings on tantalum in porous and compact forms

Strontium delivery on topographical titanium to enhance bioactivity and osseointegration in osteoporotic rats

Direct fabrication of crystalline hydroxyapatite coating on zirconium by single-step plasma electrolytic oxidation process

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