Enhanced osteogenesis and angiogenesis of calcium phosphate cement incorporated with zinc silicate by synergy effect of zinc and silicon ions

Lu, Ting; Zhang, Jing; Yuan, Xinyuan; Tang, Chenyu; Wang, Xiaolan; Xiong, Kun; Ye, Jiandong

doi:10.1016/j.msec.2021.112490

Cited by 37 publications

(15 citation statements)

References 76 publications

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“…Therefore, scientific communities have added inorganic ions, polymers, and bioactive molecules to increase the efficacy of CPC in bone regeneration by inducing its particular osteogenic and angiogenic responses in vivo. 7 Black phosphorus (BP) is a new type of two-dimensional optoelectronic material with excellent optoelectronic properties, notable photothermal effects, outstanding biocompatibility, and great degradability and shows great application potential in optoelectronic and biomedical fields. 8−11 Recent research has presented that phosphate may aid in the mineralization of biomimetic calcium phosphate, hence enhancing bone cell adhesion, differentiation, and proliferation.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, after being implanted into the body, with the degradation of the bone cement, the phosphate ion will continue to decrease and the apatite component will become less and less, which may cause incomplete repair. Therefore, scientific communities have added inorganic ions, polymers, and bioactive molecules to increase the efficacy of CPC in bone regeneration by inducing its particular osteogenic and angiogenic responses in vivo …”

Section: Introductionmentioning

confidence: 99%

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Calcium Phosphate Bone Cements Incorporated with Black Phosphorus Nanosheets Enhanced Osteogenesis

Wei

Sun

et al. 2022

ACS Biomater. Sci. Eng.

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For decades, calcium phosphate bone cements (CPCs) showed impressive advantages for their good biocompatibility, injectability, and osteoconductivity in the bone repair field. However, it is still difficult to prepare CPCs with outstanding antibacterial and self-curing properties, sufficient phosphorus release, and osteoinductivity for clinical application. Herein, we used partially crystallized calcium phosphate and dicalcium phosphate anhydrate particles incorporated with black phosphorous nanosheets to prepare calcium phosphate bone cements (CPCs). The curing time, compressive strength, photothermal properties, and degradation performance of BP/CPC were investigated. In addition, the cytocompatibility and osteoinductivity of BP/CPC were evaluated by cell adhesion, cytotoxicity, alkaline phosphatase detection, alizarin red staining, and western blot assay. The results indicated that BP/CPC showed adjustable curing time, good cytocompatibility, outstanding photothermal properties, and osteoinductivity, suggesting their potential application for bone regeneration.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Calcium Phosphate Bone Cements Incorporated with Black Phosphorus Nanosheets Enhanced Osteogenesis

Wei

Sun

et al. 2022

ACS Biomater. Sci. Eng.

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“…Surface characteristics play a key role in building the local microenvironment for a cell, with chemical composition, released ions, and nanotopography regulating cell behavior. , Zinc silicates in different forms such as crystallized Zn 2 SiO 4 or amorphous glasses can improve osteogenesis-related cells due to the release of Zn and Si ions, and they are reported to apply as a functional composition that can be incorporated in calcium phosphate and other orthopedic reconstructive materials. , Zn ions mediate many cell functions, for example, serving as a catalytic cofactor in DNA and RNA-polymerases and regulating signal molecule sequences. These behaviors improve osteogenic gene expression, e.g., Runx2, BMP-2, , and wound healing in the concentration range of 3.9–5.2 μg/mL .…”

Section: Resultsmentioning

confidence: 99%

An Extracellular Matrix-like Surface for Zn Alloy to Enhance Bone Regeneration

Mao

Zhu

Zhang

et al. 2022

ACS Appl. Mater. Interfaces

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Zn-based alloys are promising biodegradable implants for bone defect repair due to their good mechanical performance and degradability. However, local Zn2+ released from Zn-based implants can seriously affect adhering cell behaviors as well as new bone formation on implant surfaces. To address this issue, we have fabricated a bone-mimetic extracellular matrix (ECM)-like surface on Zn-1Ca implants using a hybrid process of anodization, hydrothermal treatment (HT), and fluorous-curing. The ECM-like surface consisted of Zn2SiO4 nanorods layered with collagen I (Col-I). The Zn2SiO4 nanorods were hemicrystallized and transformed by the reaction of Zn(OH)2 and SiO4 4– during the HT. The Zn2SiO4 nanorods effectively protected the substrate from corrosion; the Col-I layer decreased the degradation of Zn2SiO4 nanorods and further reduced Zn2+ release into the medium. This ECM-like surface generated a microenvironment with appropriate Zn2+ levels, nanorod-like topography, and Col-I. It significantly improved adhesion, proliferation, and differentiation of osteoblasts on implant surfaces and vascularization of endothelial cells in the extract medium. The in vivo results are in good agreement with in vitro tests, with the ECM-like surface significantly enhancing new bone formation and bone-implant contact compared to the bare implant surface. Overall, this bone-mimetic ECM-like material of Col-I layered Zn2SiO4 nanorods is a promising scaffold that promotes the bone regeneration of Zn-based implants.

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“…27,37 Moderate amounts of zinc-loaded calcium phosphate blocks of cement also substantially contributed to MSCs' ALP activity. 38 The effect of zinc-loaded bioactive ceramics on the osteogenic spectrum-specific distinction of MSCs has been well studied, and positive results have been obtained. Strontium significantly enhanced the initial adhesion and osteogenic differentiation of BMSCs in vitro and the early bone formation in animals in vivo while improving bone immune responses.…”

Section: Discussionmentioning

confidence: 99%