Enhanced osteogenesis of bone morphology protein-2 in 2- N ,6- O -sulfated chitosan immobilized PLGA scaffolds

Kong, Xiangjun; Wang, Jing; Cao, Lingyan; Yu, Yuanman; Liu, Changsheng

doi:10.1016/j.colsurfb.2014.07.012

Cited by 30 publications

(29 citation statements)

References 39 publications

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“…In one case, modification of a PLGA scaffold with 2-N, 6-O sulfated chitosan increased adsorption of rhBMP-2 onto the scaffold and prolonged its release. 67 In another example, bFGF modification of a PCL nanofibrous matrix increased cellular proliferation and attachment, and bFGF was also released over two weeks from a scaffold mineralized with hydroxyapatite and a non-mineralized scaffold. 58 …”

Section: Modifications To Controlled Release Polymersmentioning

confidence: 99%

Controlled drug release for tissue engineering

Rambhia

Peter

2015

Journal of Controlled Release

208

115

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Tissue engineering is often referred to as a three-pronged discipline, with each prong corresponding to 1) a 3D material matrix (scaffold), 2) drugs that act on molecular signaling, and 3)regenerative living cells. Herein we focus on reviewing advances in controlled release of drugs from tissue engineering platforms. This review addresses advances in hydrogels and porous scaffolds that are synthesized from natural materials and synthetic polymers for the purposes of controlled release in tissue engineering. We pay special attention to efforts to reduce the burst release effect and to provide sustained and long-term release. Finally, novel approaches to controlled release are described, including devices that allow for pulsatile and sequential delivery. In addition to recent advances, limitations of current approaches and areas of further research are discussed.

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Section: Modifications To Controlled Release Polymersmentioning

confidence: 99%

Controlled drug release for tissue engineering

Rambhia

Peter

2015

Journal of Controlled Release

208

115

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“…Consequently, this material may be of great benefit for follow‐up oromaxillofacial functional restoration. However, larger animal models with simultaneous implant placement need to be investigated for longer time periods to provide more clinically relevant data in the future …”

Section: Type Of Applicationsmentioning

confidence: 99%

“…However, larger animal models with simultaneous implant placement need to be investigated for longer time periods to provide more clinically relevant data in the future. [50][51][52] Recently, hexagonal silica mesoporous (HSM) was composited with poly(lactic acid-glycolic acid) (PLGA) to enhance the compressive strength of pure PLGA microsphere scaffolds. 48 The compressive strength of the HSM/ PLGA composite scaffolds was significantly higher than that of pure PLGA scaffolds, which was more suitable for bone repair.…”

Section: Type Of Applicationsmentioning

confidence: 99%

Silica‐based mesoporous nanobiomaterials as promoter of bone regeneration process

Shadjou

Hasanzadeh

2015

J Biomedical Materials Res

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Silica-based mesostructured nanomaterials have emerged as a full family of biomaterials with tremendous potential to address the requirements for the bone regeneration process. This review focuses on more recent advances in bone regeneration process based on silica-based mesoporous biomaterials during 2012 to January 2015. In this review, we describe application of silica-based mesoporous mesostructured nanomaterials (possessing pore sizes in the range 2-50 nm) for the bone regeneration process. We summarize the preparation methods, the effect of mesopore templates and composition on the mesopore-structure characteristics, and different forms of these materials, including particles, fibers, spheres, scaffolds, and composites. The effect of structural and textural properties of mesoporous materials on the development of new biomaterials for treatment of different bone pathologies such as infection, osteoporosis, cancer, and so forth is discussed. In addition, silica-based mesoporous bioactive glass, as a potential drug/growth factor carrier, is reviewed, which includes the composition-structure-drug delivery relationship and the functional effect on the antibacteria and tissue-stimulation properties. Also, application of different mesoporous materials on construction of 3D macroporous scaffolds for bone tissue engineering was disused. Finally, this review discusses the possibility of covalently grafting different osteoinductive agents to the silica-based mesoporous scaffold surface that act as attracting signals for bone cells to promote the bone regeneration process.

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“…Therefore, the study of the synthesis and properties of sulfonated and sulfated chitosans have attracted researchers' attention. Sulfated chitosan has been widely applied in anticoagulant drugs, antidiabetic drugs, angiogenesis promotion, osteogenesis enhancement, glycerol‐induced acute renal failure protection in rat kidneys, and fatty liver treatment . Regretfully, it has been reported that sulfated chitosan has no antimicrobial activity…”

Section: Introductionmentioning

confidence: 99%

Preparation and antimicrobial activity of sulfopropyl chitosan in an ionic liquid aqueous solution

Wang

Zheng

et al. 2017

J of Applied Polymer Sci

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To improve the solubility and antibacterial activity of chitosan and expand its applications, we synthesized sulfopropyl chitosan (SP‐CS) with various degrees of substitution (DSs) under mild and green reaction conditions in the aqueous solution of an ionic liquid by a green process. The chemical structures of the polymers were verified by Fourier transform infrared spectroscopy and 1H‐NMR, and the thermal stability was studied by thermogravimetric analysis. After modification, the water solubility of chitosan was improved significantly, and SP‐CS showed excellent solubility in water at neutral pH. The antibacterial activities of the SP‐CSs with various DSs were systematically studied for the first time by the Oxford cup method and optical density method. The results suggest that the antimicrobial properties of SP‐CS were enhanced by the introduction of sulfopropyl and increased with increasing DS. The application of chitosan could be expanded, and SP‐CS has the potential to be used as a water‐soluble antimicrobial. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44989.

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Enhanced osteogenesis of bone morphology protein-2 in 2- N ,6- O -sulfated chitosan immobilized PLGA scaffolds

Cited by 30 publications

References 39 publications

Controlled drug release for tissue engineering

Controlled drug release for tissue engineering

Silica‐based mesoporous nanobiomaterials as promoter of bone regeneration process

Preparation and antimicrobial activity of sulfopropyl chitosan in an ionic liquid aqueous solution

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