Enhanced osteogenic activity with boron-doped nanohydroxyapatite-loaded poly(butylene adipate-co-terephthalate) fibrous 3D matrix

Arslan, Aysu; Çakmak, Soner; Gümüşderelı́oğlu, Menemşe

doi:10.1080/21691401.2018.1470522

Cited by 31 publications

(26 citation statements)

References 35 publications

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“…However, a donor organ is required for this purpose; and with respect to bone, autologous grafts (the best option for seeding) are not only limited in supply but also impose donor site problems. Instead, scaffolds are being fabricated from or coated with major components of bone ECM, such as HA or type I collagen, to generate bone-like tissue in vitro 21–23 . Furthermore, 3D bioprinting with cell-loaded bioink is emerging as another attractive option 24 , albeit rooted in high-tech devices.…”

Section: Discussionmentioning

confidence: 99%

Induced Osteogenesis in Plants Decellularized Scaffolds

Lee

Jung

Park

et al. 2019

Sci Rep

103

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A three-dimensional (3D) culture system that closely replicates the in vivo microenvironment of calcifying osteoid is essential for in vitro cultivation of bone-like material. In this regard, the 3D cellulose constructs of plants may well serve as scaffolds to promote growth and differentiation of osteoblasts in culture. Our aim in this study was to generate bone-like tissue by seeding pluripotent stem cells (hiPSCs), stimulated to differentiate as osteoblasts in culture, onto the decellularised scaffolds of various plants. We then assessed expression levels of pertinent cellular markers and degrees of calcium-specific staining to gauge technical success. Apple scaffolding bearing regular pores of 300 μm seemed to provide the best construct. The bone-like tissue thus generated was implantable in a rat calvarial defect model where if helped form calcified tissue. Depending on the regularity and sizing of scaffold pores, this approach readily facilitates production of mineralized bone.

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Section: Discussionmentioning

confidence: 99%

Induced Osteogenesis in Plants Decellularized Scaffolds

Lee

Jung

Park

et al. 2019

Sci Rep

103

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“…In these studies, it has been shown that boron has positive effects on bone healing [ 20 , 25 ]. Boron (B) modulates the osteogenic effects of human bone marrow-derived mesenchymal stem cells [ 70 , 71 ] and mineralized tissue-related proteins as well as the adhesion and proliferation potential of osteoblasts [ 72 ]. In various studies using these elements separately, it has been reported that strontium and boron ions have positive effects on bone formation [ 64 , 65 , 66 , 73 ].…”

Section: Discussionmentioning

confidence: 99%

In Vivo Evaluation of the Effects of B-Doped Strontium Apatite Nanoparticles Produced by Hydrothermal Method on Bone Repair

Öztekin

Gürgenç

Dündar

et al. 2022

JFB

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In the present study, the structural, morphological, and in vivo biocompatibility of un-doped and boron (B)-doped strontium apatite (SrAp) nanoparticles were investigated. Biomaterials were fabricated using the hydrothermal process. The structural and morphological characterizations of the fabricated nanoparticles were performed by XRD, FT-IR, FE-SEM, and EDX. Their biocompatibility was investigated by placing them in defects in rat tibiae in vivo. The un-doped and B-doped SrAp nanoparticles were successfully fabricated. The produced nanoparticles were in the shape of nano-rods, and the dimensions of the nano-rods decreased as the B ratio increased. It was observed that the structural and morphological properties of strontium apatite nanoparticles were affected by the contribution of B. A stoichiometric Sr/P ratio of 1.67 was reached in the 5% B-doped sample (1.68). The average crystallite sizes were 34.94 nm, 39.70 nm, 44.93 nm, and 48.23 nm in un-doped, 1% B-doped, 5% B-doped, and 10% B-doped samples, respectively. The results of the in vivo experiment revealed that the new bone formation and osteoblast density were higher in the groups with SrAp nanoparticles doped with different concentrations of B than in the control group, in which the open defects were untreated. It was observed that this biocompatibility and the new bone formation were especially elevated in the B groups, which added high levels of strontium were added. The osteoblast density was higher in the group in which the strontium element was placed in the opened bone defect compared with the control group. However, although new bone formation was slightly higher in the strontium group than in the control group, the difference was not statistically significant. Furthermore, the strontium group had the highest amount of fibrotic tissue formation. The produced nanoparticles can be used in dental and orthopedic applications as biomaterials.

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“…In poly(butylenes adipate-co-terephthalate) (PBAT)/ boron-doped HA composite scaffold, although all scaffolds improved attachment and proliferation, an enhancement in the differentiation of human bone MSCs was observed for scaffolds containing boron-doped HA when compared to scaffolds with pure HA [35]. The study on Saos-2 cell line also showed that the addition of boron-doped HA brought a proliferative effect to the scaffolds consisting of gelatin and bacterial cellulose [27].…”

Section: Effect Of Boron On Biological Properties Of Hamentioning

confidence: 99%

“…No significant reduction in porosity of the scaffold was observed due to boron-doped HA coating. By using a similar synthesis method for boron-doped HA, a scaffold consisting of poly(butylenes adipate-coterephthalate) and 5 wt.% of boron-doped HA was produced [35]. It was detected that boron doping increased fiber diameter by decreasing pore size.…”

Section: Boron-doped Ha As a Scaffoldmentioning

confidence: 99%

Boron doped Hydroxapatites in Biomedical Applications

Uysal¹,

Yılmaz²,

Evis³

2020

Journal of Boron

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Hydroxyapatite has been widely used in biomedical applications as a coating material for implant surfaces, a drug carrier, a scaffold or composite for bone tissue engineering applications. The highly ionic structure of hydroxyapatite allows doping of various ions, resulting in an improvement in its properties. Boron is one of the elements which can be doped into hydroxyapatite structure by replacing phosphate (PO 4 3-) or hydroxyl (OH-) sites to obtain scaffolds for bone tissue engineering applications or a coating material for metal substrates. Although the effects of supplemental boron on bone, liver, and brain metabolism have been shown to have important results as a nutrient, there are very few studies in the literature on the use of boron-doped hydroxyapatite in the biomedical field. In this review, the details of synthesis methods and functional groups of boron-doped hydroxyapatite were tabulated. Generally, the addition of boron leads to the formation of rod-like morphology, while the density and Vicker's microhardness of hydroxyapatite decrease. Thermal stability and electrical insulation properties were observed to improve with boron doping. Boron was also shown to increase biodegradability, bioactivity as well as cell proliferation and differentiation of different cell types on the surface of hydroxyapatite.

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Enhanced osteogenic activity with boron-doped nanohydroxyapatite-loaded poly(butylene adipate-co-terephthalate) fibrous 3D matrix

Cited by 31 publications

References 35 publications

Induced Osteogenesis in Plants Decellularized Scaffolds

Induced Osteogenesis in Plants Decellularized Scaffolds

In Vivo Evaluation of the Effects of B-Doped Strontium Apatite Nanoparticles Produced by Hydrothermal Method on Bone Repair

Boron doped Hydroxapatites in Biomedical Applications

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