Enhanced oxidative stress in workers with a standing occupation: Table 1

Flore, Roberto; Gerardino, Laura; Santoliquido, Angelo; Pola, Roberto; Flex, Andrea; Campli, C. Di; Pola, Paolo; Tondi, Paolo

doi:10.1136/oem.2003.008805

Cited by 29 publications

(20 citation statements)

References 10 publications

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“…Strenuous exercise enhances the accumulation of secondary products of lipid peroxidation (37) and the formation of free radicals and other reactive oxygen species (45)(46)(47). A recent study compared surgery room nurses, whose work involves prolonged standing without moving, with outpatient department nurses, who can walk during their worktime (48). Interestingly, the surgery room nurses had significantly higher mean levels of reactive-oxygen-species after work.…”

Section: Discussionmentioning

confidence: 99%

Population-based study on occupational risk factors for preeclampsia and gestational hypertension

Haelterman¹,

Marcoux²,

Croteau³

et al. 2007

Scand J Work Environ Health

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Haelterman E, Marcoux S, Croteau A, Dramaix M. Population-based study on occupational risk factors for preeclampsia and gestational hypertension. Scand J Work Environ Health 2007;33(4):304-317.Objectives Preeclampsia is a leading cause of maternal and perinatal morbidity. Work-related factors may influence the occurrence of this disorder. This case-control study estimated the associations between work-related physical and psychosocial factors and the risk of preeclampsia and gestational hypertension. MethodsThe eligible women consisted of a random sample of the women who delivered a singleton live birth in 1997-1999 in six regions of Quebec and worked during pregnancy. Cases of preeclampsia (N=102) and gestational hypertension (N=99) were compared with normotensive controls (N=4381). Information on occupational exposures at the onset of pregnancy was collected during phone interviews a few weeks after delivery. Detailed information was obtained on work schedule, postures, physical exertion, work organization, noise, vibration, and extreme temperature. Adjusted odds ratios (aOR) were estimated through polytomous logistic regression. ResultsWomen standing daily at least 1 hour consecutively without walking experienced a higher risk of preeclampsia [aOR 2.5, 95% confidence interval (95% CI) 1.4-4.6], as well as women climbing stairs frequently (aOR 2.3, 95% CI 1.2-4.1) and women working more than 5 consecutive days without a day-off (aOR 3.0, 95% CI 1.0-9.5). Squatting or kneeling, pushing or pulling objects, whole-body vibration, forced pace, job strain, and no control on breaks were positively, but nonsignificantly, associated with preeclampsia. The associations were weaker for gestational hypertension.Conclusions These findings suggest that being exposed to physically demanding and stressful occupational conditions at the onset of pregnancy increases the risk of preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Population-based study on occupational risk factors for preeclampsia and gestational hypertension

Haelterman¹,

Marcoux²,

Croteau³

et al. 2007

Scand J Work Environ Health

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“…In order to monitor this "dual" effect of conventional antineoplastic treatments and to evaluate the potential indication for antioxidant supplementations, the measurement of oxidative balance in clinical practice appears to be indispensable [13]. Therefore, in the open trial described here, the effect of a breast milk-mimicking protein formula on oxidative balance of women with breast cancer undergoing conventional chemo/radio therapy was evaluated by the BAP [8,15] and d-ROMs tests [9,16], which are proven reliable analytical tools in clinical routine in several experimental studies and clinical trials [10,15,[20][21][22][23][24][25][26][27][28]. In this study, plasma antioxidant capacity, as measured by means of the BAP test at enrolment, was lower (1894.5 ± 362.5 μmol/l reduced iron) than that of apparently healthy people (>2200 μmol/l reduced iron) [8] and this is the first reported evidence of a decreased value of the BAP test in cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Improvement of antioxidant status in women conventionally treated for breast cancer after 12 months of a cow milk whey-based supplementation. A preliminary study

Landoni

Mariani

Oriani

et al. 2009

Mediterr J Nutr Metab

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Background Cancer chemo-and radiotherapy are constantly associated with unwanted side effects at least partially ascribable to oxidative stress, an imbalance between pro-oxidant and antioxidant factors. However, the possible indication and efficacy of antioxidant supplementations -including glutathione-based formulasaimed to restore the oxidative balance should be, respectively, evaluated and monitored carefully with reliable analytical tools. Aim Because previous studies on cystic fibrosis and athletes showed that high-cysteine-content, whey-based formulas were able to improve glutathione levels in cystic fibrosis and in healthy exercising people, the aim of this preliminary study was to evaluate the impact on oxidative balance of a new antioxidant supplementation, based on a high-cysteine formula containing a protein mimicking breast milk, on women conventionally treated for breast cancer. Subjects and methods Twenty women suffering from breast cancer under ambulatory conventional antineoplastic treatment were supplemented for 12 consecutive months with 10 g u.i.d. of an oral nutraceutical lipid-and lactose-free formula containing a mix of peptides from cow's milk whey having a high content of cysteine and glutamic acid as the main biochemical precursor of glutathione (Prother ® , DMF Limbiate, MI, Italy). During the study period the recruited subjects underwent a periodical (bimonthly) clinical visit, during which they were tested for oxidative balance (BAP test and d-ROMs). Before and at the end of the study the women were invited to complete the Spitzer Questionnaire. Results Plasma antioxidant capacity, as detected by the BAP test, showed a marked early trend towards a progressive increase, reaching statistical significance at the end of the treatment (2319.5 ± 288.7 vs. 1894.5 ± 362.5 μmol/l reduced iron, respectively; p = 0.007). Plasma oxidant status, as measured by means of the d-ROMs test, after an irregular time-course, increased significantly at the 12th month, compared to the baseline value (350.29 ± 39.29 vs. 407.00 ± 58.54 CARR U, respectively; p = 0.0017). The treatment was well tolerated. Discussion The breast milk-mimicking protein formula intake was associated with a restoration of biological antioxidant potential, maybe by increasing the bioavailability of antioxidant components, and reduced glutathione, with no apparent interference with the intrinsic pharmacological/chemical mechanism (oxidant species generation) of the current treatment (chemo/radiotherapy).Conclusions This preliminary study indicates that 12 months of regular oral intake of a high-content cysteine nutraceutic formula is associated with increased plasma antioxidant capacity in women conventionally treated for breast cancer. Moreover, the data from oxidative status assessment suggest that the above supplement did not interfere with oxidant production, the increase of which is related to the cancer and antineoplastic treatment itself. Finally, the d-ROMs and BAP tests were shown to be very reliable tools to monitor ambulator...

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“…Los leucocitos alteran la microcirculación e inducen daño tisular por secreción de citocinas, proteasas lisosomales, y radicales libres. Esto desarrolla una aterogénesis por procesos enzimáticos, incluyendo a la xantina oxidasa, al nicotinadenindinucleotido fosfatado (NADPH) y a la sintetasa del óxido nítrico, aumentando el riesgo cardiovascular 36 .…”

Section: Enfermedades Cardiovascularesunclassified

Enfermedades potenciales derivadas de factores de riesgo presentes en la industria de producción de alimentos

Aguilar¹,

Pérez-Manríquez²,

Díaz³

2011

Med. segur. trab.

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Octubre -diciembre 2011 Med Segur Trab (Internet) 2011 57 (225) [300][301][302][303][304][305][306][307][308][309][310][311][312] Resumen La industria de la producción de alimentos presenta factores de riesgo laborales que van de los químicos hasta los psicosociales, por lo mismo los grupos de enfermedades que potencialmente se vinculan con ellos pueden ser aparentemente inocuas o poner en riesgo la vida del trabajador, lo que evidencia la necesidad de contar con una revisión extensa de la bibliografía nacional e internacional de enfermedades vinculadas a los riesgos presentes en los puestos de las áreas de producción hasta los puestos de mantenimiento de la industria de los alimentos. El propósito de esta publicación es evidenciar al lector el vínculo existente entre los factores de riesgos presentes en la industria de los alimentos y las enfermedades que estos pueden generar, y que frecuentemente son calificadas como enfermedades generales cuando en realidad son laborales, y así proporcionarle fundamentos sólidos según referencias nacionales e internacionales para un diagnóstico situacional y de salud más completo.Objetivos: Esta revisión pretende evidenciar el vínculo existente entre los factores de riesgos presentes en la industria de los alimentos y las enfermedades que pueden generarse a consecuencia de estos. Conclusiones: Un diagnóstico a fondo de enfermedades de presunto origen ocupacional implica el conocimiento y reconocimiento absoluto de los factores de riesgo laborales a los que se exponen los trabajadores diariamente o eventualmente, así como identificar rápidamente los efectos a la salud reales y potenciales de estos factores por parte de todos los responsables, directos e indirectos, de salud ocupacional al interior de los centros de trabajo.

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Enhanced oxidative stress in workers with a standing occupation: Table 1

Cited by 29 publications

References 10 publications

Population-based study on occupational risk factors for preeclampsia and gestational hypertension

Population-based study on occupational risk factors for preeclampsia and gestational hypertension

Improvement of antioxidant status in women conventionally treated for breast cancer after 12 months of a cow milk whey-based supplementation. A preliminary study

Enfermedades potenciales derivadas de factores de riesgo presentes en la industria de producción de alimentos

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