Enhanced photoacoustic imaging in tissue-mimicking phantoms using polydopamine-shelled perfluorocarbon emulsion droplets

Mesoporous, anisotropic nanostructures from bioinspired polymeric catecholamine neurotransmitters and their potential application as photoacoustic imaging agents

“…All photoacoustic imaging experiments were performed using a Vevo LAZR photoacoustic imaging system (FUJIFILM VisualSonics), following a previously reported protocol. 43 The particle samples were dispersed either in water or in blood-mimicking phantom ( μ a = 4.0 cm −1 ) to obtain final concentrations of 0.0, 0.125, 0.25, 0.50, and 1.00 mg mL −1 . Methylene blue in either water or blood-mimicking phantom (0.00, 0.5, 1.0, 5.0, and 10.0 mg mL −1 ) was used as a control (molecular photoacoustic agents).…”

“…Fabricated nanostructures from PNE and PEP, as well as PDA, were tested as photoacoustic contrast agents, as these materials share similar optical properties as previously reported photoacoustically active PDA colloidal materials. [39][40][41][42] Photoacoustic imaging experiments were conducted based on our previous work 43 using tissue-mimicking phantoms-aqueous dispersions of 1.5% Intralipid s and different concentrations of India ink (Fig. S2, ESI †).…”

“…Tissue-mimicking phantoms used as dispersing medium and external phase for imaging were prepared using ultrapure water, India ink, and Intralipid s dispersion, based on our previous optimisations. 43 The final concentration of Intralipid s in all phantoms prepared was 1.5% (v/v) and the concentrations of India ink were 0.017, 0.026, and 0.034% (v/v), corresponding to absorption coefficients of 0.1, 0.3, and 0.5 cm À1 .…”

Recent Advances in Perfluorocarbon-Based Delivery Systems for Cancer Theranostics

“…PFC-based micro/nanocarriers are generally formulated with further surface coating or functionalized linkages (Figure A). This, on the one hand, enhances the internal stability of the system by reducing the diffusion of PFC molecules to the external phase while, on the other hand, shielding the surface from aggregation, opsonization, and phagocytosis, thereby enhancing the pharmacokinetic properties. − The most commonly used approach for surface coating is the PEGylation of the shell materials. PEG polymers are FDA-approved excipients that offer a long hydrophilic block and are proven to effectively decrease the size growth of the PFC droplets during storage .…”

Special issue on “Ultrasound-assisted engineering of materials for biomedical uses”

“…Vidallon et al [2] have reported on the ultrasound-assisted fabrication of polydopamine-shelled perfluorocarbon emulsion droplets, which were used as photoacoustic signal enhancers using tissue-mimicking phantoms. The authors surveyed different parameters for controlling size distributions, where different phantoms could be designed (optical scattering and absorption of tissues), which highlights the potential of the system for predicting the in vivo efficiency of colloidal photoacoustic imaging agents.…”